Effects of sildenafil on hypoxic pulmonary vascular function in dogs

Journal of Applied Physiology

Volumn 101, Issue 4, 2006, Pages 1085-1090

  Fesler, Pierre ^a   Pagnamenta, Alberto ^b   Rondelet, Benoit ^b   Kerbaul, François ^b   Naeije, Robert ^b  

^a LAPEYRONIE HOSPITAL   (France)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Nitric oxide; Pulmonary hypertension; Pulmonary vascular impedance; Pulmonary vascular resistance; Right ventricle; Sodium nitroprusside

Indexed keywords

CYCLIC GMP; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PHOSPHODIESTERASE V; SILDENAFIL; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTERY OCCLUSION; ARTICLE; BLOOD GAS ANALYSIS; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG EFFECT; HEART ATRIUM PRESSURE; HEART MUSCLE CONTRACTILITY; HEART RIGHT VENTRICLE; HEMODYNAMIC PARAMETERS; HYPOXIA; IMPEDANCE; LUNG ARTERY PRESSURE; LUNG BLOOD VESSEL; LUNG CIRCULATION; LUNG VASCULAR RESISTANCE; NONHUMAN; OXYGEN BREATHING; PRIORITY JOURNAL; SYSTOLE;

ADMINISTRATION, INHALATION; ANESTHETICS, INTRAVENOUS; ANIMALS; ANOXIA; BLOOD PRESSURE; CHLORALOSE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; HYPERTENSION, PULMONARY; INJECTIONS, INTRAVENOUS; NITRIC OXIDE; NITROPRUSSIDE; PIPERAZINES; PULMONARY CIRCULATION; VASCULAR RESISTANCE; VASODILATOR AGENTS;

EID: 33749346097     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00332.2006     Document Type: Article

References (45)

1. Brimioulle S, Maggiorini M, Stephanazzi J, Vermeulen F, Lejeune P, and Naeije R. Effects of low flow on pulmonary vascular flow-pressure curves and pulmonary vascular impedance. Cardiovasc Res 42: 183-192, 1999.
2. Brimioulle S, Wauthy P, Ewalenko P, Rondelet B, Vermeulen F, Kerbaul F, and Naeije R. Single-beat estimation of right ventricular end-systolic pressure-volume relationship. Am J Physiol Heart Circ Physiol 284: H1625-H1630, 2003.
3. Cannon RO 3rd, Schechter AN, Panza JA, Ognibene FP, Pease-Fye ME, Waclawiw MA, Shelhamer JH, and Gladwin MT. Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery. J Clin Invest 108: 279-287, 2001.
4. Colley PS and Cheney FW. Sodium nitroprusside increases Qs/Qt in dogs with regional atelectasis. Anesthesiology 47: 338-341, 1977.
5. Corbin J, Rannels S, Neal D, Chang P, Grimes K, Beasley A, and Francis S. Sildenafil citrate does not affect cardiac contractility in human or dog heart. Curr Med Res Opin 19: 747-752, 2003.
6. Cremers B, Scheler M, Maack C, Wendler O, Schafers HJ, Sudkamp M, and Bohm M. Effects of sildenafil (viagra) on human myocardial contractility, in vitro arrhythmias, and tension of internal mammaria arteries and saphenous veins. J Cardiovasc Pharmacol 41: 734-743, 2003.
7. Dantzker DR. The influence of cardiovascular function on gas exchange. Clin Chest Med 4: 149-159, 1983.
8. Fesler P, Pagnamenta A, Vachiery JL, Brimioulle S, Abdel KS, Boonstra A, Delcroix M, Channick RN, Rubin LJ, and Naeije R. Single arterial occlusion to locate resistance in patients with pulmonary hypertension. Eur Respir J 21: 31-36, 2003.
9. Frostell CG, Blomqvist H, Hedenstierna G, Lundberg J, and Zapol WM. Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation. Anesthesiology 78: 427-435, 1993.
10. Galie N, Ghofrani HA, Torbicki A, Barst RJ, Rubin LJ, Badesch D, Fleming T, Parpia T, Burgess G, Branzi A, Grimminger F, Kurzyna M, and Simonneau G. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med 353: 2148-2157, 2005.
11. Getman CE, Goetzman BW, and Bennett S. Age-dependent effects of sodium nitroprusside and dopamine in lambs. Pediatr Res 29: 329-333, 1991.
12. Ghofrani HA, Reichenberger F, Kohstall MG, Mrosek EH, Seeger T, Olschewski H, Seeger W, and Grimminger F. Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial. Ann Intern Med 141: 169-177, 2004.
13. Ghofrani HA, Schermuly RT, Rose F, Wiedemann R, Kohstall MG, Kreckel A, Olschewski H, Weissmann N, Enke B, Ghofrani S, Seeger W, and Grimminger F. Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension. Am J Respir Crit Care Med 167: 1139-1141, 2003.
14. Ghofrani HA, Voswinckel R, Reichenberger F, Olschewski H, Haredza P, Karadas B, Schermuly RT, Weissmann N, Seeger W, and Grimminger F. Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study. J Am Coll Cardiol 44: 1488-1496, 2004.
15. Guazzi M, Tumminello G, Di Marco F, and Guazzi MD. Influences of sildenafil on lung function and hemodynamics in patients with chronic heart failure. Clin Pharmacol Ther 76: 371-378, 2004.
16. Kingwell BA, McPherson GA, and Korner PI. Assessment of gain of tachycardia and bradycardia responses of cardiac baroreflex. Am J Physiol Heart Circ Physiol 260: H1254-H1263, 1991.
17. Kleinsasser A, Loeckinger A, Hoermann C, Puehringer F, Mutz N, Bartsch G, and Lindner KH. Sildenafil modulates hemodynamics and pulmonary gas exchange. Am J Respir Crit Care Med 163: 339-343, 2001.
18. Maggiorini M, Brimioulle S, De Canniere D, Delcroix M, Wauthy P, and Naeije R. Pulmonary vascular impedance response to hypoxia in dogs and minipigs: effects of inhaled nitric oxide. J Appl Physiol 79: 1156-1162, 1995.
19. Maggiorini M, Melot C, Gilbert E, Vermeulen F, and Naeije R. Pulmonary vascular resistance in dogs and minipigs - effects of hypoxia and inhaled nitric oxide. Respir Physiol 111: 213-222, 1998.
20. Mélot C, Naeije R, Hallemans R, Lejeune P, and Mols P. Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man. Respir Physiol 68: 11-27, 1987.
21. Michail GW, Prasad SK, Li W, Rogers P, Chester AH, Bayne S, Stephens D, Khan M, Gibbs JS, Evans TW, Mitchell A, Yacoub MH, and Gatzoulis MA. Clinical and haemodynamic effects of sildenafil in pulmonary hypertension: acute and mid-term effects. Eur Heart J 25: 431-436, 2004.
22. Murray PA, Lodato RF, and Michael JR. Neural antagonists modulate pulmonary vascular pressure-flow plots in conscious dogs. J Appl Physiol 60: 1900-1907, 1986.
23. Naeije R, Lejeune P, Leeman M, Melot C, and Deloof T. Pulmonary arterial pressure-flow plots in dogs: effects of isoflurane and nitroprusside. J Appl Physiol 63: 969-977, 1987.
24. Nichols WW and O'Rourke MF. McDonalds Blood Flow in Arteries. London: Arnold, 1998.
25. Parsons GH, Leventhal JP, Hansen MM, and Goldstein JD. Effect of sodium nitroprusside on hypoxic pulmonary vasoconstriction in the dog. J Appl Physiol 51: 288-292, 1981.
26. Phillips BG, Kato M, Pesek CA, Winnicki M, Narkiewicz K, Davison D, and Somers VK. Sympathetic activation by sildenafil. Circulation 102: 3068-3073, 2000.
27. Preston IR, Hill NS, Gambardella LS, Warburton RR, and Klinger JR. Synergistic effects of ANP and sildenafil on cGMP levels and amelioration of acute hypoxic pulmonary hypertension. Exp Biol Med (Maywood) 229: 920-925, 2004.
28. Reffelmann T and Kloner RA. Effects of sildenafil on myocardial infarct size, microvascular function, and acute ischemic left ventricular dilation. Cardiovasc Res 59: 441-449, 2003.
29. Richalet JP, Gratadour P, Robach P, Pham I, Dechaux M, Joncquiert-Latarjet A, Mollard P, Brugniaux J, and Cornolo J. Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension. Am J Respir Crit Care Med 171: 275-281, 2005.
30. Roberts JD, Chen TY, Kawai N, Wain J, Dupuy P, Shimouchi A, Bloch K, Polaner D, and Zapol WM. Inhaled nitric oxide reverses pulmonary vasoconstriction in the hypoxic and acidotic newborn lamb. Circ Res 72: 246-254, 1993.
31. Romand JA, Pinsky MR, Firestone L, Zar HA, and Lancaster JR Jr. Inhaled nitric oxide partially reverses hypoxic pulmonary vasoconstriction in the dog. J Appl Physiol 76: 1350-1355, 1994.
32. Rondelet B, Kerbaul F, Van Beneden R, Motte S, Fesler P, Hubloue I, Remmelink M, Brimioulle S, Salmon I, Ketelslegers JM, and Naeije R. Signaling molecules in overcirculation-induced pulmonary hypertension in piglets: effects of sildenafil therapy. Circulation 110: 2220-2225, 2004.
33. Rovira I, Chen TY, Winkler M, Kawai N, Bloch KD, and Zapol WM. Effects of inhaled nitric oxide on pulmonary hemodynamics and gas exchange in an ovine model of ARDS. J Appl Physiol 76: 345-355, 1994.
34. Sagawa K. The end-systolic pressure-volume relation of the ventricle: definition, modifications and clinical use. Circulation 63: 1223-1227, 1981.
35. Schermuly RT, Kreisselmeier KP, Ghofrani HA, Yilmaz H, Butrous G, Ermert L, Ermert M, Weissmann N, Rose F, Guenther A, Walmrath D, Seeger W, and Grimminger F. Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats. Am J Respir Crit Care Med 169: 39-45, 2004.
36. Schuster DP and Dennis DR. Leukotriene inhibitors do not block hypoxic pulmonary vasoconstriction in dogs. J Appl Physiol 62: 1808-1813, 1987.
37. Sebkhi A, Strange JW, Phillips SC, Wharton J, and Wilkins MR. Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertension. Circulation 107: 3230-3235, 2003.
38. Takimoto E, Champion HC, Belardi D, Moslehi J, Mongillo M, Mergia E, Montrose DC, Isoda T, Aufiero K, Zaccolo M, Dostmann WR, Smith CJ, and Kass DA. cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism. Circ Res 96: 100-109, 2005.
39. Thomas MK, Francis SH, and Corbin JD. Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase. J Biol Chem 265: 14964-14970, 1990.
40. Wallis RM, Corbin JD, Francis SH, and Ellis P. Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro. Am J Cardiol 83: 3C-12C, 1999.
41. Wegener JW, Nawrath H, Wolfsgruber W, Kuhbandner S, Werner C, Hofmann F, and Feil R. cGMP-dependent protein kinase I mediates the negative inotropic effect of cGMP in the murine myocardium. Circ Res 90: 18-20, 2002.
42. Weimann J, Ullrich R, Hromi J, Fujino Y, Clark MW, CB, Bloch KD, and Zapol WM. Sildenafil is a pulmonary vasodilator in awake lambs with acute pulmonary hypertension. Anesthesiology 92: 1702-1712, 2000.
43. Wharton J, Strange JW, Moller GM, Growcott EJ, Ren X, Franklyn AP, Phillips SC, and Wilkins MR. Antiproliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells. Am J Respir Crit Care Med 172: 105-113, 2005.
44. Winer BJ. Statistical Principles in Experimental Design. New York: McGraw-Hill, 1971.
45. Zhao L, Mason NA, Morrell NW, Kojonazarov B, Sadykov A, Maripov A, Mirrakhimov MM, Aldashev A, and Wilkins MR. Sildenafil inhibits hypoxia-induced pulmonary hypertension. Circulation 104: 424-428, 2001.