Mir-32 functions as a tumor suppressor and directly targets ezh2 in human oral squamous cell carcinoma

Medical Science Monitor

Volumn 20, Issue , 2014, Pages 2527-2535

  Zhang, Dafeng ^a   Ni, Zhenyu ^a   Xu, Xingqiao ^a   Xiao, Jin ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Cell proliferation; MicroRNAs; Mouth neoplasms; Neoplasm invasiveness; Prognosis

Indexed keywords

EZH2 PROTEIN, HUMAN; MICRORNA; MIRN32 MICRORNA, HUMAN; POLYCOMB REPRESSIVE COMPLEX 2;

FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; MALE; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; MOUTH TUMOR; MULTIVARIATE ANALYSIS; NUCLEOTIDE SEQUENCE; PATHOLOGY; SQUAMOUS CELL CARCINOMA; SURVIVAL; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

BASE SEQUENCE; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; MALE; MICRORNAS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MOUTH NEOPLASMS; MULTIVARIATE ANALYSIS; POLYCOMB REPRESSIVE COMPLEX 2; SURVIVAL ANALYSIS; TRANSFECTION;

EID: 84914148772     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.892636     Document Type: Article

References (30)

1. Sharma P, Saxena S, Aggarwal P: Trends in the epidemiology of oral squa-mous cell carcinoma in Western UP: an institutional study. Indian J Dent Res, 2010; 21: 316-19
2. Massano J, Regateiro FS, Januario G, Ferreira A: Oral squamous cell carcinoma: review of prognostic and predictive factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2006; 102: 67-76
3. Bartel DP: MicroRNAs: target recognition and regulatory functions. Cell, 2009; 136: 215-33
4. Heneghan HM, Miller N, Kerin MJ: MiRNAs as biomarkers and therapeutic targets in cancer. Curr Opin Pharmacol, 2010; 10: 543-50
5. Zhang H, Qi F, Cao Y et al: Down-regulated microRNA-101 in bladder transitional cell carcinoma is associated with poor prognosis. Med Sci Monit, 2014; 20: 812-17
6. Liu Y, Zhao J, Zhang PY et al: MicroRNA-10b targets E-cadherin and modulates breast cancer metastasis. Med Sci Monit, 2012; 18(8): BR299-308
7. Shang C, Lu YM, Meng LR: MicroRNA-125b down-regulation mediates en-dometrial cancer invasion by targeting ERBB2. Med Sci Monit, 2012; 18(4): BR149-55
8. Wu W, Yang J, Feng X et al: MicroRNA-32 (miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth, migration, and invasion in colorectal carcinoma cells. Mol Cancer, 2013; 12: 30
9. Petillo D, Kort EJ, Anema J et al: MicroRNA profling of human kidney cancer subtypes. Int J Oncol, 2009; 35: 109-14
10. Ambs S, Prueitt RL, Yi M et al: Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer Res, 2008; 68: 6162-70
11. Pichiorri F, Suh SS, Ladetto M et al: MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. Proc Natl Acad Sci USA, 2008; 105: 12885-90
12. Zhang J, Kuai X, Song M et al: microRNA-32 inhibits the proliferation and invasion of the SGC-7901 gastric cancer cell line. Oncol Lett, 2014; 7: 270-74
13. Xu JQ, Zhang WB, Wan R, Yang YQ: MicroRNA-32 inhibits osteosarcoma cell proliferation and invasion by targeting Sox9. Tumour Biol, 2014; 35(10): 9847-53
14. Mahmoudi T, Verrijzer CP: Chromatin silencing and activation by Polycomb and trithorax group proteins. Oncogene, 2001; 20: 3055-66
15. Simon JA, Lange CA: Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res, 2008; 647: 21-29
16. Kidani K, Osaki M, Tamura T et al: High expression of EZH2 is associated with tumor proliferation and prognosis in human oral squamous cell carcinomas. Oral Oncol, 2009; 45: 39-46
17. Liu L, Guo J, Yu L et al: miR-101 regulates expression of EZH2 and contributes to progression of and cisplatin resistance in epithelial ovarian cancer. Tumour Biol, 2014 [Epub ahead of print]
18. Guo Y, Ying L, Tian Y et al: miR-144 downregulation increases bladder cancer cell proliferation by targeting EZH2 and regulating Wnt signaling. Febs J, 2013; 280: 4531-38
19. Tao T, Liu D, Liu C et al: Autoregulatory feedback loop of EZH2/miR-200c/ E2F3 as a driving force for prostate cancer development. Biochim Biophys Acta, 2014; 1839: 858-65
20. Wu W, Yang P, Feng X et al: The relationship between and clinical signif-cance of MicroRNA-32 and phosphatase and tensin homologue expression in colorectal cancer. Genes Chromosomes Cancer, 2013; 52: 1133-40
21. Leite KR, Tomiyama A, Reis ST et al: MicroRNA expression profiles in the progression of prostate cancer - from high-grade prostate intraepithelial neoplasia to metastasis. Urol Oncol, 2013;31: 796-801
22. Jalava SE, Urbanucci A, Latonen L et al: Androgen-regulated miR-32 targets BTG2 and is overexpressed in castration-resistant prostate cancer. Oncogene, 2012; 31: 4460-71
23. Gocek E, Wang X, Liu X et al: MicroRNA-32 upregulation by 1,25-dihydroxyvi-tamin D3 in human myeloid leukemia cells leads to Bim targeting and inhibition of AraC-induced apoptosis. Cancer Res, 2011; 71: 6230-29
24. Liu GF, Tang D, Li P et al: S-1-based combination therapy S-1 monotherapy in advanced gastric cancer: A meta-analysis. World J Gastroenterol, 2014; 20: 310-18
25. Mishra R, Chhatbar C, Singh SK: HIV-1 Tat C-mediated regulation of tumor necrosis factor receptor-associated factor-3 by microRNA 32 in human mi-croglia. J Neuroinfammation, 2012; 9: 131
26. Zhao L, Yu Y, Wu J et al: Role of EZH2 in oral squamous cell carcinoma car-cinogenesis. Gene, 2014; 537: 197-202
27. Brennecke J, Stark A, Russell RB, Cohen SM: Principles of microRNA-target recognition. PLoS Biol, 2005; 3: e85
28. Krek A, Grun D, Poy MN et al: Combinatorial microRNA target predictions. Nat Genet, 2005; 37: 495-500
29. Squarize CH, Castilho RM, Santos Pinto D Jr: Immunohistochemical evidence of PTEN in oral squamous cell carcinoma and its correlation with the his-tological malignancy grading system. J Oral Pathol Med, 2002;31: 379-84.
30. Misuno K, Liu X, Feng S, Hu S: Quantitative proteomic analysis of sphere-forming stem-like oral cancer cells. Stem Cell Res Ther, 2013; 4: 156