Peptide-coated liposomal fasudil enhances site specific vasodilation in pulmonary arterial hypertension

Molecular Pharmaceutics

Volumn 11, Issue 12, 2014, Pages 4374-4384

  Nahar, Kamrun ^a   Absar, Shahriar ^a   Gupta, Nilesh ^a   Kotamraju, Venkata Ramana ^b   McMurtry, Ivan F ^c   Oka, Masahiko ^c   Komatsu, Masanobu ^b   Nozik Grayck, Eva ^d   Ahsan, Fakhrul ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b BURNHAM INSTITUTE   (United States)

^c UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^d Children's Hospital Colorado   (United States)

Author keywords

CAR peptide; inhalation delivery; peptide link liposomes; pulmonary arterial hypertension

Indexed keywords

CAR PEPTIDE; CYCLOPEPTIDE; FASUDIL; LIPOSOME; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; 1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; PEPTIDE; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTERIAL PRESSURE; ARTICLE; CELL VIABILITY; CHRONIC DISEASE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG COATING; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; DRUG SAFETY; DRUG STABILITY; DRUG UPTAKE; ENCAPSULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPOSOMAL DELIVERY; LUNG; LUNG ALVEOLUS MACROPHAGE; LUNG ARTERY PRESSURE; LUNG BLOOD VESSEL; LUNG HEMODYNAMICS; MALE; NONHUMAN; PHARMACOKINETICS; PHYSICAL CHEMISTRY; POLYDISPERSITY INDEX; PULMONARY ARTERIAL SMOOTH MUSCLE CELL; PULMONARY HYPERTENSION; RAT; SMOOTH MUSCLE FIBER; SYSTEMIC CIRCULATION; VASODILATATION; ZETA POTENTIAL; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; HYPERTENSION, PULMONARY; SPRAGUE DAWLEY RAT;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; HYPERTENSION, PULMONARY; LIPOSOMES; MALE; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; VASODILATOR AGENTS;

EID: 84914099910     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500456k     Document Type: Article

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