Fresh versus frozen embryo transfer: Backing clinical decisions with scientific and clinical evidence

Human Reproduction Update

Volumn 20, Issue 6, 2014, Pages 808-821

  Evans, Jemma ^a,b   Hannan, Natalie J ^a,c   Edgell, Tracey A ^a   Vollenhoven, Beverley J ^b,d,e   Lutjen, Peter J ^e   Osianlis, Tiki ^b,d,e   Salamonsen, Lois A ^a,b   Rombauts, Luk J F ^b,d,e  

^a HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d SOUTHERN HEALTH   (Australia)

^e MONASH IVF   (Australia)

Author keywords

Endometrial receptivity; Frozen embryo transfer; Human chorionic gonadotrophin; IVF success; Ovarian stimulation

Indexed keywords

CHORIONIC GONADOTROPIN; CD34 ANTIGEN;

ANTEPARTUM HEMORRHAGE; ARTICLE; BLASTOCYST; BLOOD VESSEL PERMEABILITY; CRYOPRESERVATION; EMBRYO TRANSFER; ENDOMETRIUM; FERTILIZATION IN VITRO; FLUORESCENCE IN SITU HYBRIDIZATION; FRESH EMBRYO TRANSFER; FROZEN EMBRYO TRANSFER; GENETIC SCREENING; GENOMICS; HUMAN; INTRACELLULAR SPACE; LARGE FOR GESTATIONAL AGE; LUTEINIZING HORMONE RELEASE; MENSTRUAL CYCLE; META ANALYSIS (TOPIC); MULTIPLE PREGNANCY; NONHUMAN; OOCYTE MATURATION; OVARY HYPERSTIMULATION; PERINATAL MORTALITY; PREGNANCY OUTCOME; PREGNANCY RATE; PREMATURE LABOR; PROTEOMICS; RANDOMIZED CONTROLLED TRIAL (TOPIC); REPRODUCTION; SMALL FOR DATE INFANT; SYSTEMATIC REVIEW (TOPIC); TRANSCRIPTOMICS; VITRIFICATION; EVIDENCE BASED MEDICINE; FEMALE; IMMUNOHISTOCHEMISTRY; METABOLISM; NIDATION; OVARIAN HYPERSTIMULATION SYNDROME; PHYSIOLOGY; PREGNANCY; PROCEDURES;

ANTIGENS, CD34; CRYOPRESERVATION; EMBRYO IMPLANTATION; EMBRYO TRANSFER; ENDOMETRIUM; EVIDENCE-BASED MEDICINE; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MENSTRUAL CYCLE; OVARIAN HYPERSTIMULATION SYNDROME; PREGNANCY; PREGNANCY OUTCOME;

EID: 84913592405     PISSN: 13554786     EISSN: 14602369     Source Type: Journal    
DOI: 10.1093/humupd/dmu027     Document Type: Article

References (139)

1. AbdelHafez FF, Desai N, Abou-Setta AM, Falcone T, Goldfarb J. Slow freezing, vitrification and ultra-rapid freezing of human embryos: a systematic review and meta-analysis. Reprod Biomed Online 2010;20:209-222.
2. Aboulghar M. Symposium: updateon prediction and management of OHSS. Prevention of OHSS. Reprod Biomed Online 2009;19:33-42.
3. Aflatoonian A, Oskouian H, Ahmadi S, Oskouian L. Can fresh embryo transfers be replaced by cryopreserved-thawed embryo transfers in assisted reproductive cycles? A randomized controlled trial. J Assist Reprod Genet 2010;27:357-363.
4. Amor DJ, Xu JX, Halliday JL, Francis I, Healy DL, Breheny S, Baker HW, Jaques AM. Pregnancies conceived using assisted reproductive technologies (ART) have low levels of pregnancy-associated plasma protein-A (PAPP-A) leading to a high rate of false-positive results in first trimester screening for Down syndrome. Hum Reprod 2009;24:1330-1338.
5. Beier HM, Beckman JO. Implications and consequences of the German Embryo Protection Act. Hum Reprod 1991;6:607-608.
6. Bermejo A, Cerrillo M, Ruiz-AlonsoM, Blesa D, SimónC, Pellicer A, Garcia-Velasco JA. Impact of final oocyte maturation using gonadotropin-releasing hormone agonist triggering and different luteal support protocols on endometrial gene expression. Fertil Steril 2014;101:138-146.
7. Berndt S, Perrier d'Hauterive S, Blacher S, Pequeux C, Lorquet S, Munaut C, Applanat M, Herve MA, Lamande N, Corvol P et al. Angiogenic activity of human chorionic gonadotropin through LH receptor activation on endothelial and epithelial cells of the endometrium. FASEB J 2006;20:2630-2632.
8. Biyiksiz PC, Filiz S, Vural B. Is sildenafil citrate affect endometrial receptivity? An immunohistochemical study. Gynecol Endocrinol 2011;27:767-774.
9. Bodri D, Sunkara SK, Coomarasamy A. Gonadotropin-releasing hormone agonists versus antagonists for controlled ovarian hyperstimulation in oocyte donors: a systematic review and meta-analysis. Fertil Steril 2011;95:164-169.
10. Bonduelle ML, Dodd R, Liebaers I, Van Steirteghem A, Williamson R, Akhurst R. Chorionic gonadotrophin-beta mRNA, a trophoblast marker, is expressed in human 8-cell embryos derived from tripronucleate zygotes. Hum Reprod 1988; 3:909-914.
11. BoomsmaCM,Kavelaars A, Eijkemans MJ, Fauser BC, Heijnen CJ, Macklon NS. Ovarian stimulation for in vitro fertilization alters the intrauterine cytokine, chemokine, and growth factor milieu encountered by the embryo. Fertil Steril 2010;94:1764-1768.
12. Bossuyt PM, Reitsma JB. The STARD initiative. Standards for reporting of diagnostic accuracy. Lancet 2003;361:71.
13. Braat DD, Schutte JM, Bernardus RE, Mooij TM, van Leeuwen FE. Maternal death related to IVF in the Netherlands 1984-2008. Hum Reprod 2010;25:1782-1786.
14. Cameo P, Szmidt M, Strakova Z, Mavrogianis P, Sharpe-Timms KL, Fazleabas AT. Decidualization regulates the expression of the endometrial chorionic gonadotropin receptor in the primate. Biol Reprod 2006;75:681-689.
15. Carson DD, Bagchi I, Dey SK, Enders AC, Fazleabas AT, Lessey BA, Yoshinaga K. Embryo implantation. Dev Biol 2000;223:217-237.
16. Chambers GM, Illingworth PJ, Sullivan EA. Assisted reproductive technology: public funding and the voluntary shift to single embryo transfer in Australia. Med J Aust 2011;195:594-598.
17. Chan CC, Ng EH, Chan MM, Tang OS, Lau EY, Yeung WS, Ho PC. Bioavailability of hCG after intramuscular or subcutaneous injection in obese and non-obese women. Hum Reprod 2003;18:2294-2297.
18. Chang EM, Han JE, Won HJ, Kim YS, Yoon TK, Lee WS. Effect of estrogen priming through luteal phase and stimulation phase in poor responders in in-vitro fertilization. J Assist Reprod Genet 2011;29:225-230.
19. Cheong Y, Boomsma C, Heijnen C, Macklon N. Uterine secretomics: a window on the maternal-embryo interface. Fertil Steril 2013;99:1093-1099.
20. Chetkowski RJ, Kiltz RJ, Salyer WR. In premature luteinization, progesterone induces secretory transformation of the endometrium without impairment of embryo viability. Fertil Steril 1997;68:292-297.
21. Clarke JF, van Rumste MM, Farquhar CM, Johnson NP, MolBW, Herbison P. Measuring outcomes in fertility trials: can we rely on clinical pregnancy rates? Fertil Steril 2010; 94:1647-1651.
22. Cobo A, de los Santos MJ, Castello D, Gamiz P, Campos P, Remohi J. Outcomes of vitrified early cleavage-stage and blastocyst-stage embryos in a cryopreservation program: evaluation of 3,150warming cycles. Fertil Steril 2012;98:1138-1146. e1131.
23. Conti M, Harwood JP, Hsueh AJ, Dufau ML, Catt KJ. Gonadotropin-induced loss of hormone receptors and desensitization of adenylate cyclase in the ovary. J Biol Chem 1976;251:7729-7731.
24. Damewood MD,Shen W, Zacur HA, Schlaff WD,Rock JA,Wallach EE. Disappearance of exogenously administered human chorionic gonadotropin. Fertil Steril 1989; 52:398-400.
25. Delvigne A, Rozenberg S. Review of clinical course and treatment of ovarian hyperstimulation syndrome (OHSS). Hum Reprod Update 2003;9:77-96.
26. Edgell TA, Rombauts LJ, Salamonsen LA. Assessing receptivity in the endometrium: the need for a rapid, non-invasive test. Reprod Biomed Online 2013;27:486-496.
27. El Bahja D, Hertz P, Schweitzer T, Lestrade F, Ragage JP. Frozen embryo transfer protocol: does spontaneous cycle give good results?. Gynecol Obstet Fertil 2013; 41:648-652.
28. Endo T, Honnma H, Hayashi T, Chida M, Yamazaki K, Kitajima Y, Azumaguchi A, Kamiya H, Kudo R. Continuation of GnRH agonist administration for 1 week, after hCG injection, prevents ovarian hyperstimulation syndrome following elective cryopreservation of all pronucleate embryos. Hum Reprod 2002;17:2548-2551.
29. Engmann L, DiLuigi A, Schmidt D, Benadiva C, Maier D, Nulsen J. The effect of luteal phase vaginal estradiol supplementation on the success of in vitro fertilization treatment: a prospective randomized study. Fertil Steril 2008;89:554-561.
30. Ertzeid G, Storeng R. The impact of ovarian stimulation on implantation and fetal development in mice. Hum Reprod 2001;16:221-225.
31. Evans J, Salamonsen LA. Too much of a good thing? Experimental evidence suggests prolonged exposure to hCG is detrimental to endometrial receptivity. Hum Reprod 2013;28:1610-1619.
32. Evans J, Catalano RD, Brown P, Sherwin R, Critchley HO, Fazleabas AT, Jabbour HN. Prokineticin 1 mediates fetal-maternal dialogue regulating endometrial leukemia inhibitory factor. FASEB J 2009;23:2165-2175.
33. Evans J, Hannan NJ, Hincks C, Rombauts LJ, Salamonsen LA. Defective soil for a fertile seed? Altered endometrial development is detrimental to pregnancy success. PLoS ONE 2012;7:e53098.
34. Fatemi HM, Kyrou D, Bourgain C, Van den Abbeel E, Griesinger G, Devroey P. Cryopreserved-thawed human embryo transfer: spontaneous natural cycle is superior to human chorionic gonadotropin-induced natural cycle. Fertil Steril 2010; 94:2054-2058.
35. Fauser BC, Devroey P. Reproductive biology and IVF: ovarian stimulation and luteal phase consequences. Trends Endocrinol Metab 2003;14:236-242.
36. Fauser BC, Bouchard P, Coelingh Bennink HJ, Collins JA, Devroey P, Evers JL, van Steirteghem A. Alternative approaches in IVF. Hum Reprod Update 2002;8:1-9.
37. FerrarettiAP, GoossensV, de Mouzon J, Bhattacharya S, Castilla JA, KorsakV, Kupka M, Nygren KG, Nyboe Andersen A, European IVF monitoringet al. Assisted reproductive technology in Europe, 2008: results generated from European registers by ESHRE. Hum Reprod 2012;27:2571-2584.
38. Ferraretti AP, Goossens V, Kupka M, Bhattacharya S, de Mouzon J, Castilla JA, Erb K, Korsak V, Nyboe Andersen A. Assisted reproductive technology in Europe, 2009: results generated from European registers by ESHRE. Hum Reprod 2013; 28:2318-2331.
39. Garrido-GomezT, Ruiz-Alonso M, Blesa D, Diaz-Gimeno P, Vilella F, Simon C. Profiling the gene signature of endometrial receptivity: clinical results. Fertil Steril 2013; 99:1078-1085.
40. Giorgetti C, Vanden Meerschaut F, De Roo C, Saunier O, Quarello E, Hairion D, Penaranda G, Chabert-Orsini V, De Sutter P. Multivariate analysis identifies the estradiol level at ovulation triggering as an independent predictor of the first trimester pregnancy-associated plasma protein-A level in IVF/ICSI pregnancies. Hum Reprod 2013;28:2636-2642.
41. Gleicher N, Kushnir VA, Barad DH. What 'misguided campaign' against single embryo transfer? Hum Reprod 2014;29:380-381.
42. Griesinger G, Dafopoulos K, Schultze-Mosgau A, JelkmannW, von Otte S, Diesing D, Diedrich K. Vascular endothelial growth factor response to exogenous chorionic gonadotropic hormone in the luteal phase of women with a history of severe ovarian hyperstimulation syndrome. Arch Gynecol Obstet 2006;274:29-33.
43. Griesinger G, Kolibianakis EM, Papanikolaou EG, Diedrich K, Van Steirteghem A, Devroey P, Ejdrup Bredkjaer H, Humaidan P. Triggering of final oocyte maturation with gonadotropin-releasing hormone agonist or human chorionic gonadotropin. Live birth after frozen-thawed embryo replacement cycles. Fertil Steril 2007;88:616-621.
44. Groenewoud ER, Cantineau AE, Kollen BJ, Macklon NS, Cohlen BJ. Whatis the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles? A systematic review and meta-analysis. Hum Reprod Update 2013;19:458-470.
45. Halliday JL, Ukoumunne OC, Baker HW, Breheny S, Jaques AM, Garrett C, Healy D, Amor D. Increased risk of blastogenesis birth defects, arising in the first 4 weeks of pregnancy, after assisted reproductive technologies. Hum Reprod 2010; 25:59-65.
46. Handyside AH. 24-chromosome copy number analysis: a comparison of available technologies. Fertil Steril 2013;100:595-602.
47. Haouzi D, Assou S, Mahmoud K, Tondeur S, Reme T, Hedon B, De Vos J, Hamamah S. Gene expression profile of human endometrial receptivity: comparison between natural and stimulated cycles for the same patients. Hum Reprod 2009;24: 1436-1445.
48. Haouzi D, Assou S, Dechanet C, Anahory T, Dechaud H, De Vos J, Hamamah S. Controlled ovarian hyperstimulation for in vitro fertilization alters endometrial receptivity in humans: protocol effects. Biol Reprod 2010;82:679-686.
49. Harada M, Peegel H, Menon KM. Expression of vascular endothelial growth factor A during ligand-induced down-regulation of luteinizing hormone receptor in the ovary. Mol Cell Endocrinol 2010;328:28-33.
50. Healy DL, Breheny S, Halliday J, Jaques A, Rushford D,Garrett C, Talbot JM, Baker HW. Prevalence and risk factors for obstetric haemorrhage in 6730 singleton births after assisted reproductive technology in Victoria Australia.HumReprod 2010;25:265-274.
51. Hildenbrand A, Lalitkumar L, Nielsen S, Gemzell-Danielsson K, Stavreus-Evers A. Expression of aquaporin 2 in human endometrium. Fertil Steril 2006;86:1452-1458.
52. Hope N, Rombauts L. Can an educational DVD improve the acceptability of elective single embryo transfer?Arandomized controlled study. Fertil Steril 2010;94:489-495.
53. Horcajadas JA, Riesewijk A, Polman J, van Os R, Pellicer A, Mosselman S, Simon C. Effect of controlled ovarian hyperstimulation in IVF on endometrial gene expression profiles. Mol Hum Reprod 2005;11:195-205.
54. Horcajadas JA, Minguez P, Dopazo J, Esteban FJ, Dominguez F, Giudice LC, Pellicer A, Simon C. Controlled ovarian stimulation induces a functional genomic delay of the endometrium with potential clinical implications. J Clin Endocrinol Metab 2008; 93:4500-4510.
55. Humaidan P, Bredkjaer HE, Bungum L, Bungum M, Grondahl ML, Westergaard L, Andersen CY. GnRH agonist (buserelin) or hCG for ovulation induction in GnRH antagonist IVF/ICSI cycles: a prospective randomized study. Hum Reprod 2005; 20:1213-1220.
56. Humaidan P, Polyzos NP, Alsberg B, Erb K, Mikkelsen AL, Elbaek HO, Papanikolaou EG, Andersen CY. GnRHa trigger and individualized luteal phase hCG support according to ovarian response to stimulation: two prospective randomized controlled multi-centre studies in IVF patients. Hum Reprod 2013; 28:2511-2521.
57. Imudia AN, Awonuga AO, Doyle JO, Kaimal AJ, Wright DL, Toth TL, Styer AK. Peak serum estradiol level during controlled ovarian hyperstimulation is associated with increased risk of small for gestational age and preeclampsia in singleton pregnancies after in vitro fertilization. Fertil Steril 2012;97:1374-1379.
58. Imudia AN, Awonuga AO, Kaimal AJ, Wright DL, Styer AK, Toth TL. Elective cryopreservation of all embryos with subsequent cryothaw embryo transfer in patients at risk for ovarian hyperstimulation syndrome reduces the risk of adverse obstetric outcomes: a preliminary study. Fertil Steril 2013;99:168-173.
59. Jovanovic A, Kramer B. The effect of hyperstimulation on transforming growth factor beta(1) and beta(2) in the rat uterus: possible consequences for embryo implantation. Fertil Steril 2010;93:1509-1517.
60. Kalra SK, Ratcliffe SJ, Coutifaris C, Molinaro T, Barnhart KT. Ovarian stimulation and low birth weight in newborns conceived through in vitro fertilization. Obstet Gynecol 2011;118:863-871.
61. Keskintepe L, Sher G, Machnicka A, Tortoriello D, Bayrak A, Fisch J, AgcaY. Vitrification of human embryos subjected to blastomere biopsy for pre-implantation genetic screening produces higher survival and pregnancy rates than slow freezing. J Assist Reprod Genet 2009;26:629-635.
62. Kessler MJ, Reddy MS, Shah RH, BahlOP. Structures ofN-glycosidic carbohydrate units of human chorionic gonadotropin. J Biol Chem 1979;254:7901-7908.
63. Kliman HJ, Honig S,Walls D, Luna M, McSweet JC, Copperman AB. Optimization of endometrial preparation results in a normal endometrial function test (EFT) and good reproductive outcome in donor ovum recipients. J Assist Reprod Genet 2006; 23:299-303.
64. Kolibianakis EM, Devroey P. The luteal phase after ovarian stimulation. Reprod Biomed Online 2002;5(Suppl 1):26-35.
65. Kolibianakis EM, Bourgain C, Papanikolaou EG, Camus M, Tournaye H, Van Steirteghem AC, Devroey P. Prolongation of follicular phase by delaying hCG administration results in a higher incidence of endometrial advancement on the day of oocyte retrieval in GnRH antagonist cycles. Hum Reprod 2005;20: 2453-2456.
66. Kushnir VA, Barad DH, Gleicher N. Defining assisted reproductive technology success. Fertil Steril 2013a;100:e30.
67. Kushnir VA, Vidali A, Barad DH, Gleicher N. The status of public reporting of clinical outcomes in assisted reproductive technology. Fertil Steril 2013b; 100:736-741.
68. Kyrou D, Kolibianakis EM, Venetis CA, Papanikolaou EG, Bontis J, Tarlatzis BC. How to improve the probability of pregnancy in poor responders undergoing in vitro fertilization: a systematic review and meta-analysis. Fertil Steril 2009; 91:749-766.
69. Kyrou D, Kolibianakis EM, Fatemi HM, Grimbizis GF, Theodoridis TD, Camus M, Tournaye H, Tarlatzis BC, Devroey P. Spontaneous triggering of ovulation versus HCG administration in patients undergoing IUI: a prospective randomized study. Reprod Biomed Online 2012;25:278-283.
70. Labarta E, Martinez-Conejero JA, Alama P, Horcajadas JA, Pellicer A, Simon C, Bosch E. Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod 2011;26:1813-1825.
71. Lakkakorpi JT, Pietila EM, Aatsinki JT, Rajaniemi HJ. Human chorionic gonadotrophin (CG)-induced down-regulation of the rat luteal LH/CG receptor results in part from the down-regulation of its synthesis, involving increased alternative processing of the primary transcript. J Mol Endocrinol 1993;10:153-162.
72. Lessey BA, Lebovic DI, Taylor RN. Eutopic endometrium in women with endometriosis: ground zero for the study of implantation defects. Semin Reproduct Med 2013;31:109-124.
73. Levi Setti PE, Albani E, Cesana A, Novara PV, Zannoni E, Baggiani AM, Morenghi E, Arfuso V, Scaravelli G. Italian Constitutional Court modifications of a restrictive assisted reproduction technology law significantly improve pregnancy rate. Hum Reprod 2011;26:376-381.
74. Li R, Qiao J, Wang L, Li L, Zhen X, Liu P, Zheng X. MicroRNA array and microarray evaluation of endometrial receptivity in patients with high serum progesterone levels on the day of hCG administration. Reproduct Biol Endocrinol 2011;9:29.
75. Licht P, Losch A, Dittrich R, Neuwinger J, Siebzehnrubl E, Wildt L. Novel insights into human endometrial paracrinology and embryo-maternal communication by intrauterine microdialysis. Hum Reprod Update 1998;4:532-538.
76. Licht P, Russu V, Lehmeyer S, Wildt L. Molecular aspects of direct LH/hCG effects on human endometrium-lessons from intrauterinemicrodialysis in the human female in vivo. Reprod Biol 2001a;1:10-19.
77. Licht P, Russu V, Wildt L. On the role of human chorionic gonadotropin (hCG) in the embryo-endometrial microenvironment: implications for differentiation and implantation. Semin Reprod Med 2001b;19:37-47.
78. Licht P, FluhrH, Neuwinger J,Wallwiener D, Wildt L. Is human chorionic gonadotropin directly involved in the regulation of human implantation? Mol Cell Endocrinol 2007; 269:85-92.
79. Lindsay LA, Murphy CR. Ovarian hyperstimulation affects fluid transporters in the uterus: a potential mechanism in uterine receptivity. Reprod Fertil Develop 2013; doi:10.1071/RD12396.
80. Liu Y, Lee KF, Ng EH, Yeung WS, Ho PC. Gene expression profiling of human peri-implantation endometria between natural and stimulated cycles. Fertil Steril 2008;90:2152-2164.
81. Lopata A, Hay DL. The potential of early human embryos to form blastocysts, hatch from their zona and secrete HCG in culture. Hum Reprod 1989;4:87-94.
82. Lopata A, Oliva K. Chorionic gonadotrophin secretion by human blastocysts. Hum Reprod 1993;8:932-938.
83. Loutradi KE, Kolibianakis EM, Venetis CA, Papanikolaou EG, Pados G, Bontis I, Tarlatzis BC. Cryopreservation of human embryos by vitrification or slow freezing: a systematic review and meta-analysis. Fertil Steril 2008;90:186-193.
84. Macaldowie A, Wang YA, Chambers GM, Sullivan EA. Assisted Reproductive Technology in Australia and New Zealand 2011. Sydney: National Perinatal Epidemiology and Statistics Unit, the University of New SouthWales, 2013.
85. Macklon NS, van der Gaast MH, Hamilton A, Fauser BC, Giudice LC. The impact of ovarian stimulation with recombinant FSH in combination with GnRH antagonist on the endometrial transcriptome in the window of implantation. Reprod Sci 2008; 15:357-365.
86. Maheshwari A, Bhattacharya S. Elective frozen replacement cycles for all: ready for prime time? Hum Reprod 2013;28:6-9.
87. Maheshwari A, Pandey S, Shetty A, Hamilton M, Bhattacharya S. Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of frozen thawed versus fresh embryos generated through in vitro fertilization treatment: a systematic review and meta-analysis. Fertil Steril 2012;98:368-377.
88. Martinez MC, Ruiz FJ, Garcia-Velasco JA. GnRH-agonist triggering to avoid ovarian hyperstimulation syndrome: a review of the evidence. Curr Drug Targets 2013; 14:843-849.
89. Martini S, Van Voorhis BJ, Stegmann BJ, Sparks AE, Shochet T, Zimmerman MB, Ryan GL. In vitro fertilization patients support a single blastocyst transfer policy. Fertil Steril 2011;96:993-997.
90. Mastenbroek S, Twisk M, van der Veen F, Repping S. Preimplantation genetic screening: a systematic review and meta-analysis of RCTs. Hum Reprod Update 2011; 17:454-466.
91. Meldrum DR. Pregnancies and deliveries per fresh cycle are no longer adequate indicators of in vitro fertilization program quality: how should registries adapt? Fertil Steril 2013;100:620-621.
92. Menon KM, Menon B. Structure, function and regulation of gonadotropin receptors-a perspective. Mol Cell Endocrinol 2012;356:88-97.
93. Min JK, Breheny SA, MacLachlan V, Healy DL. What is the most relevant standard of success in assisted reproduction? The singleton, term gestation, live birth rate per cycle initiated: the BESST endpoint for assisted reproduction. Hum Reprod 2004;19:3-7.
94. Murray MJ, Meyer WR, Zaino RJ, Lessey BA, Novotny DB, Ireland K, Zeng D, Fritz MA. A critical analysis of the accuracy, reproducibility, and clinical utility of histologic endometrial dating in fertile women. Fertil Steril 2004;81: 1333-1343.
95. Navot D, Bergh P. Preparation of the human endometrium for implantation. Ann N Y Acad Sci 1991;622:212-219.
96. Nelson SM. Venous thrombosis during assisted reproduction: novel risk reduction strategies. Thromb Res 2013;131(Suppl 1):S1-S3.
97. NoyesRW, HertigAT, Rock J. Dating the endometrial biopsy.AmJ Obstet Gynecol 1975; 122:262-263.
98. Ormond KE. From genetic counseling to 'genomic counseling'. Mol Genet Genomic Med 2013;1:189-193.
99. Paiva P, Hannan NJ, Hincks C, Meehan KL, Pruysers E, Dimitriadis E, Salamonsen LA. Human chorionic gonadotrophin regulates FGF2 and other cytokines produced by human endometrial epithelial cells, providing a mechanism for enhancing endometrial receptivity. Hum Reprod 2011;26:1153-1162.
100. Papanikolaou EG, VerpoestW, Fatemi H, Tarlatzis B, Devroey P, Tournaye H. A novel method of luteal supplementation with recombinant luteinizing hormone when a gonadotropin-releasing hormone agonist is used instead of human chorionic gonadotropin for ovulation triggering: a randomized prospective proof of concept study. Fertil Steril 2011;95:1174-1177.
101. Peegel H, Towns R, Nair A, Menon KM. A novel mechanism for the modulation of luteinizing hormone receptor mRNA expression in the rat ovary. Mol Cell Endocrinol 2005;233:65-72.
102. Pelkonen S, Koivunen R, Gissler M, Nuojua-Huttunen S, Suikkari AM, Hyden-Granskog C, Martikainen H, Tiitinen A, Hartikainen AL. Perinatal outcome of children born after frozen and fresh embryo transfer: the Finnish cohort study 1995-2006. Hum Reprod 2010;25:914-923.
103. Perrier d'Hauterive S, Charlet-Renard C, Berndt S, Dubois M, Munaut C, Goffin F, Hagelstein MT, Noel A, Hazout A, Foidart JM et al. Human chorionic gonadotropin and growth factors at the embryonic-endometrial interface control leukemia inhibitory factor (LIF) and interleukin 6 (IL-6) secretion by human endometrial epithelium. Hum Reprod 2004;19:2633-2643.
104. Pinborg A, Wennerholm UB, Romundstad LB, Loft A, Aittomaki K, Soderstrom-Anttila V, Nygren KG, Hazekamp J, Bergh C. Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis. Hum Reprod Update 2010;19:87-104.
105. ReboisRV, Fishman PH. Down-regulation of gonadotropin receptors in a murine Leydig tumor cell line. J Biol Chem 1984;259:3096-3101.
106. Roque M, Lattes K, Serra S, Sola I, Geber S, Carreras R, Checa MA. Fresh embryo transfer versus frozen embryo transfer in in vitro fertilization cycles: a systematic review and meta-analysis. Fertil Steril 2013;99:156-162.
107. Roy TK, Bradley CK, Bowman MC, McArthur SJ. Single-embryo transfer of vitrified-warmed blastocysts yields equivalent live-birth rates and improved neonatal outcomes compared with fresh transfers. Fertil Steril 2014;101:1294-1301.
108. Rubio C, Rodrigo L, Mir P, Mateu E, Peinado V, Milan M, Al-Asmar N, Campos-Galindo I, Garcia S, Simon C. Use of array comparative genomic hybridization (array-CGH) for embryo assessment: clinical results. Fertil Steril 2013;99:1044-1048.
109. Ruiz-Alonso M, Blesa D, Diaz-Gimeno P, Gómez E, Fernández-Sánchez M, Carranza F, Carrera J, Vilella F, Pellicer A, Simón C. The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure. Fertil Steril 2013;100:818-824.
110. Salamonsen LA, Nie G, Hannan NJ, Dimitriadis E. Society for Reproductive Biology Founders' Lecture 2009. Preparing fertile soil: the importance of endometrial receptivity. Reprod Fertil Dev 2009;21:923-934.
111. Sazonova A, Kallen K, Thurin-Kjellberg A, Wennerholm UB, Bergh C. Neonatal and maternal outcomes comparing women undergoing two in vitro fertilization (IVF) singleton pregnancies and women undergoing one IVF twin pregnancy. Fertil Steril 2012;99:731-737.
112. Schoolcraft WB, Katz-Jaffe MG. Comprehensive chromosome screening of trophectoderm with vitrification facilitates elective single-embryo transfer for infertile women with advanced maternal age. Fertil Steril 2013;100:615-619.
113. Scott KL, Hong KH, Scott RT Jr. Selecting the optimal time to perform biopsy for preimplantation genetic testing. Fertil Steril 2013a;100:608-614.
114. ScottRTJr,UphamKM, FormanEJ, Zhao T, TreffNR.Cleavage-stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial. Fertil Steril 2013b;100:624-630.
115. Seyhan A, Ata B, Polat M, Son WY, Yarali H, Dahan MH. Severe early ovarian hyperstimulation syndrome following GnRH agonist trigger with the addition of 1500 IU hCG. Hum Reprod 2013;28:2522-2528.
116. Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozenthawed embryo transfer in normal responders. Fertil Steril 2011a;96: 344-348.
117. Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfers in high responders. Fertil Steril 2011b;96:516-518.
118. Sharpe RM. hCG-induced decrease in availability of rat testis receptors. Nature 1976; 264:644-646.
119. Sherwin JR, Sharkey AM, Cameo P, Mavrogianis PM, Catalano RD, Edassery S, Fazleabas AT. Identification of novel genes regulated by chorionic gonadotropin in baboon endometrium during the window of implantation. Endocrinology 2007; 148:618-626.
120. Stillman RJ, Richter KS, Jones HWJ. Refuting a misguided campaign against the goal of single-embryo transfer and singleton birth in assisted reproduction. Hum Reprod 2013;28:2599-2607.
121. Thomas K, Thomson AJ, Sephton V, Cowan C, Wood S, Vince G, Kingsland CR, Lewis-Jones DI. The effect of gonadotrophic stimulation on integrin expression in the endometrium. Hum Reprod 2002;17:63-68.
122. Thomas K, Thomson A, Wood S, Kingsland C, Vince G, Lewis-Jones I. Endometrial integrin expression in women undergoing in vitro fertilization and the association with subsequent treatment outcome. Fertil Steril 2003a;80:502-507.
123. Thomas K, Thomson AJ,Wood SJ, Kingsland CR, VinceG, Lewis-Jones DI. Endometrial integrin expression in women undergoing IVF and ICSI: a comparison of the two groups and fertile controls. Hum Reprod 2003b;18:364-369.
124. Tulac S, Overgaard MT, Hamilton AE, Jumbe NL, Suchanek E, Giudice LC. Dickkopf-1, an inhibitor ofWnt signaling, is regulated by progesterone in human endometrial stromal cells. J Clin Endocrinol Metab 2006;91:1453-1461.
125. Ubaldi F, Bourgain C, Tournaye H, Smitz J, Van Steirteghem A, Devroey P. Endometrial evaluation by aspiration biopsy on the day of oocyte retrieval in the embryo transfer cycles in patients with serum progesterone rise during the follicular phase. Fertil Steril 1997;67:521-526.
126. Van Vaerenbergh I, Van Lommel L, Ghislain V, In't Veld P, Schuit F, Fatemi HM, Devroey P, Bourgain C. In GnRH antagonist/rec-FSH stimulated cycles, advanced endometrial maturation on the day of oocyte retrieval correlates with altered gene expression. Hum Reprod 2009;24:1085-1091.
127. Venetis CA, Kolibianakis EM, Bosdou JK, Tarlatzis BC. Progesterone elevation and probability of pregnancy after IVF: a systematic review and meta-analysis of over 60 000 cycles. Hum Reprod Update 2013;19:433-457.
128. Venn A, Hemminki E, Watson L, Bruinsma F, Healy D. Mortality in a cohort of IVF patients. Hum Reprod 2001;16:2691-2696.
129. Vilella F, Ramirez LB, Simon C. Lipidomics as an emerging tool to predict endometrial receptivity. Fertil Steril 2013;99:1100-1106.
130. Wennerholm UB, Henningsen AK, Romundstad LB, Bergh C, Pinborg A, Skjaerven R, Forman J, Gissler M, Nygren KG, Tiitinen A. Perinatal outcomes of children born after frozen-thawed embryo transfer: a Nordic cohort study from the CoNARTaS group. Hum Reprod 2013;28:2545-2553.
131. Whelan JG III, Vlahos NF. The ovarian hyperstimulation syndrome. Fertil Steril 2000; 73:883-896.
132. Wilcox AJ, Baird DD,Weinberg CR. Time of implantation of the conceptus and loss of pregnancy. N Engl J Med 1999;340:1796-1799.
133. Winand R, Hens K, Dondorp W, de Wert G, Moreau Y, Vermeesch JR, Liebaers I, Aerts J. In vitro screening of embryos by whole-genome sequencing: now, in the future or never? Hum Reprod 2014;29:842-851.
134. Xiao Z, Zhou X, Xu W, Yang J, Xie Q. Natural cycle is superior to hormone replacement therapy cycle for vitrificated-preserved frozen-thawed embryo transfer. Syst Biol Reprod Med 2012;58:107-112.
135. Yang Z, Liu J, Collins GS, Salem SA, Liu X, Lyle SS, PeckAC, Sills ES, Salem RD. Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study. Mol Cytogenet 2012;5:24.
136. Yen SS, Llerena O, Little B, Pearson OH. Disappearance rates of endogenous luteinizing hormone and chorionic gonadotropin in man. J Clin Endocrinol Metab 1968;28:1763-1767.
137. YoshiiN,HamataniT, InagakiN,HosakaT, InoueO,YamadaM,MachiyaR,YoshimuraY, Odawara Y. Successful implantation after reducing matrix metalloproteinase activity in the uterine cavity. Reprod Biol Endocrinol 2013;11:37.
138. YoussefMA, Van der Veen F, Al-Inany HG, Griesinger G, MochtarMH, Aboulfoutouh I, Khattab SM, vanWely M. Gonadotropin-releasing hormone agonist versusHCGfor oocyte triggering in antagonist assisted reproductive technology cycles. Cochrane Database Syst Rev 2011;13:CD003719.
139. Zhang XJ, Yang YZ, LvQ,Wang Y, Cao XH, Li XJ, Liao MX, Guo C. The impact of two different thaw protocols on outcomes of vitrified cleavage-stage embryos transfer. Cryo Lett 2012;33:411-417.