Too much of a good thing? Experimental evidence suggests prolonged exposure to hCG is detrimental to endometrial receptivity

Human Reproduction

Volumn 28, Issue 6, 2013, Pages 1610-1619

  Evans, Jemma ^a,b   Salamonsen, Lois A ^a,b  

^a MONASH MEDICAL CENTRE   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

assisted reproduction; endometrium; hCG; receptivity

Indexed keywords

CETRORELIX; CHORIONIC GONADOTROPIN; GONADORELIN AGONIST; GONADORELIN ANTAGONIST; LUTEINIZING HORMONE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NAFARELIN ACETATE; RECOMBINANT FOLLITROPIN; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ARTICLE; BLASTOCYST; CELL ADHESION; CELL CULTURE; CONTROLLED STUDY; EMBRYO TRANSFER; ENDOMETRIUM; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFERTILITY THERAPY; INTRACYTOPLASMIC SPERM INJECTION; MENSTRUAL CYCLE; NONHUMAN; OOCYTE DONATION; ORAL CONTRACEPTION; PREGNANCY RATE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; TIGHT JUNCTION; WESTERN BLOTTING; CELL LINE; DOWN REGULATION; DRUG EFFECTS; GENETICS; METABOLISM; NIDATION; PHOSPHORYLATION;

PAPIO;

CELL LINE; CHORIONIC GONADOTROPIN; DOWN-REGULATION; EMBRYO IMPLANTATION; ENDOMETRIUM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; PHOSPHORYLATION; RECEPTORS, LH; REPRODUCTIVE TECHNIQUES, ASSISTED;

EID: 84878288709     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/det055     Document Type: Article

References (33)

1. Banerjee P, Sapru K, Strakova Z, Fazleabas AT. Chorionic gonadotropin regulates prostaglandin E synthase via a phosphatidylinositol 3-kinase-extracellular regulatory kinase pathway in a human endometrial epithelial cell line: implications for endometrial responses for embryo implantation. Endocrinology 2009;150:4326-4337.
2. Bourgain C, Devroey P. The endometrium in stimulated cycles for IVF. Hum Reprod Update 2003;9:515-522.
3. Cahill DJ, Wardle PG. Management of infertility. BMJ 2002;325:28-32.
4. Cameo P, Szmidt M, Strakova Z, Mavrogianis P, Sharpe-Timms KL, Fazleabas AT. Decidualization regulates the expression of the endometrial chorionic gonadotropin receptor in the primate. Biol Reprod 2006;75:681-689.
5. Conti M, Harwood JP, Hsueh AJ, Dufau ML, Catt KJ. Gonadotropin-induced loss of hormone receptors and desensitization of adenylate cyclase in the ovary. J Biol Chem 1976;251:7729-7731.
6. Devroey P, Bourgain C, Macklon NS, Fauser BC. Reproductive biology and IVF: ovarian stimulation and endometrial receptivity. Trends Endocrinol Metab 2004;15:84-90.
7. Dickinson RE, Stewart AJ, Myers M, Millar RP, Duncan WC. Differential expression and functional characterization of luteinizing hormone receptor splice variants in human luteal cells: implications for luteolysis. Endocrinology 2009;150:2873-2881.
8. Ertzeid G, Storeng R. The impact of ovarian stimulation on implantation and fetal development in mice. Hum Reprod 2001;16:221-225.
9. Evans J, Catalano RD, Brown P, Sherwin R, Critchley HO, Fazleabas AT, Jabbour HN. Prokineticin 1 mediates fetal-maternal dialogue regulating endometrial leukemia inhibitory factor. FASEB J 2009;23: 2165-2175.
10. Fatemi HM, Kyrou D, Bourgain C, Van den Abbeel E, Griesinger G, Devroey P. Cryopreserved-thawed human embryo transfer: spontaneous natural cycle is superior to human chorionic gonadotropin-induced natural cycle. Fertil Steril 2010;94:2054-2058.
11. Kolibianakis E, Bourgain C, Albano C, Osmanagaoglu K, Smitz J, Van Steirteghem A, Devroey P. Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin releasing hormone antagonists, and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up. Fertil Steril 2002;78:1025-1029.
12. Kolibianakis EM, Bourgain C, Platteau P, Albano C, Van Steirteghem AC, Devroey P. Abnormal endometrial development occurs during the luteal phase of nonsupplemented donor cycles treated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists. Fertil Steril 2003;80:464-466.
13. Kolibianakis EM, Bourgain C, Papanikolaou EG, Camus M, Tournaye H, Van Steirteghem AC, Devroey P. Prolongation of follicular phase by delaying hCG administration results in a higher incidence of endometrial advancement on the day of oocyte retrieval in GnRH antagonist cycles. Hum Reprod 2005;20:2453-2456.
14. Kosmas IP, Tatsioni A, Fatemi HM, Kolibianakis EM, Tournaye H, Devroey P. Human chorionic gonadotropin administration vs. luteinizing monitoring for intrauterine insemination timing, after administration of clomiphene citrate: a meta-analysis. Fertil Steril 2007; 87:607-612.
15. Kyrou D, Kolibianakis EM, Fatemi HM, Grimbizis GF, Theodoridis TD, Camus M, Tournaye H, Tarlatzis BC, Devroey P. Spontaneous triggering of ovulation versus HCG administration in patients undergoing IUI: a prospective randomized study. Reprod Biomed Online 2012;25:278-283.
16. Lakkakorpi JT, Pietila EM, Aatsinki JT, Rajaniemi HJ. Human chorionic gonadotrophin (CG)-induced down-regulation of the rat luteal LH/CG receptor results in part from the down-regulation of its synthesis, involving increased alternative processing of the primary transcript. J Mol Endocrinol 1993;10:153-162.
17. Licht P, Russu V, Lehmeyer S, Wildt L. Molecular aspects of direct LH/hCG effects on human endometrium-lessons from intrauterine microdialysis in the human female in vivo. Reprod Biol 2001;1:10-19.
18. Lopata A, Oliva K. Chorionic gonadotrophin secretion by human blastocysts. Hum Reprod 1993;8:932-938.
19. Murphy CR. Junctional barrier complexes undergo major alterations during the plasma membrane transformation of uterine epithelial cells. Hum Reprod 2000;15(Suppl. 3):182-188.
20. Murphy CR, Rogers PA, Hosie MJ, Leeton J, Beaton L. Tight junctions of human uterine epithelial cells change during the menstrual cycle: a morphometric study. Acta Anat (Basel) 1992;144:36-38.
21. Noyes RW, Haman JO. Accuracy of endometrial dating; correlation of endometrial dating with basal body temperature and menses. Fertil Steril 1953;4:504-517.
22. Paiva P, Hannan NJ, Hincks C, Meehan KL, Pruysers E, Dimitriadis E, Salamonsen LA. Human chorionic gonadotrophin regulates FGF2 and other cytokines produced by human endometrial epithelial cells, providing a mechanism for enhancing endometrial receptivity. Hum Reprod 2011;26:1153-1162.
23. Papanikolaou EG, Bourgain C, Kolibianakis E, Tournaye H, Devroey P. Steroid receptor expression in late follicular phase endometrium in GnRH antagonist IVF cycles is already altered, indicating initiation of early luteal phase transformation in the absence of secretory changes. Hum Reprod 2005;20:1541-1547.
24. Peegel H, Towns R, Nair A, Menon KM. A novel mechanism for the modulation of luteinizing hormone receptor mRNA expression in the rat ovary. Mol Cell Endocrinol 2005;233:65-72.
25. Prapas N, Tavaniotou A, Panagiotidis Y, Prapa S, Kasapi E, Goudakou M, Papatheodorou A, Prapas Y. Low-dose human chorionic gonadotropin during the proliferative phase may adversely affect endometrial receptivity in oocyte recipients. Gynecol Endocrinol 2009;25:53-59.
26. Rebois RV, Fishman PH. Down-regulation of gonadotropin receptors in a murine Leydig tumor cell line. J Biol Chem 1984;259:3096-3101.
27. Rogers PA, Murphy CR. Morphometric and freeze fracture studies of human endometrium during the peri-implantation period. Reprod Fertil Dev 1992;4:265-269.
28. Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders. Fertil Steril 2011;96:344-348.
29. Sharpe RM. hCG-induced decrease in availability of rat testis receptors. Nature 1976;264:644-646.
30. Sherwin JR, Sharkey AM, Cameo P, Mavrogianis PM, Catalano RD, Edassery S, Fazleabas AT. Identification of novel genes regulated by chorionic gonadotropin in baboon endometrium during the window of implantation. Endocrinology 2007;148:618-626.
31. Sherwin JR, Hastings JM, Jackson KS, Mavrogianis PA, Sharkey AM, Fazleabas AT. The endometrial response to chorionic gonadotropin is blunted in a baboon model of endometriosis. Endocrinology 2010;151:4982-4993.
32. Srisuparp S, Strakova Z, Brudney A, Mukherjee S, Reierstad S, Hunzicker-Dunn M, Fazleabas AT. Signal transduction pathways activated by chorionic gonadotropin in the primate endometrial epithelial cells. Biol Reprod 2003;68:457-464.
33. Weissman A, Horowitz E, Ravhon A, Steinfeld Z, Mutzafi R, Golan A, Levran D. Spontaneous ovulation versus HCG triggering for timing natural-cycle frozen-thawed embryo transfer: a randomized study. Reprod Biomed Online 2011;23:484-489.