Vigorous physical activity impairs myocardial function in patients with arrhythmogenic right ventricular cardiomyopathy and in mutation positive family members

European Journal of Heart Failure

Volumn 16, Issue 12, 2014, Pages 1337-1344

  Saberniak, Jørg ^a,b   Hasselberg, Nina E ^a,b   Borgquist, Rasmus ^c   Platonov, Pyotr G ^c   Sarvari, Sebastian I ^a,b   Smith, Hans Jørgen ^a   Ribe, Margareth ^a,b   Holst, Anders G ^d   Edvardsen, Thor ^a,b   Haugaa, Kristina H ^a,b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d Rigshospitalet   (Denmark)

Author keywords

Arrhythmogenic cardiomyopathy; Exercise; Heart failure; Myocardial function; Ventricular arrhythmia

Indexed keywords

DESMOCOLLIN; DESMOGLEIN 2; DESMOPLAKIN; GENOMIC DNA; PLAKOPHILIN; RYANODINE RECEPTOR 2; ANTINEOPLASTIC AGENT;

ADULT; ARTICLE; ATHLETE; CARDIOVASCULAR MAGNETIC RESONANCE; ECHOCARDIOGRAPHY; EXON; FAMILY; FEMALE; GENE MUTATION; GENETIC ANALYSIS; GENETIC SCREENING; HEART FUNCTION; HEART RIGHT VENTRICLE DYSPLASIA; HEART RIGHT VENTRICLE EJECTION FRACTION; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; MUTATION; PHYSICAL ACTIVITY; CROSS-SECTIONAL STUDY; ECHOGRAPHY; EXERCISE; GENETICS; HEART LEFT VENTRICLE FUNCTION; HEART RIGHT VENTRICLE FUNCTION; HEART STROKE VOLUME; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA; ATHLETES; CROSS-SECTIONAL STUDIES; ECHOCARDIOGRAPHY; EXERCISE; FEMALE; GENETIC TESTING; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MUTATION; STROKE VOLUME; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR DYSFUNCTION, RIGHT; VENTRICULAR FUNCTION, LEFT; VENTRICULAR FUNCTION, RIGHT;

EID: 84913588827     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1002/ejhf.181     Document Type: Article

References (29)

1. Sen-Chowdhry S, Morgan RD, Chambers JC, McKenna WJ,. Arrhythmogenic cardiomyopathy: etiology, diagnosis, and treatment. Annu Rev Med 2010; 61: 233-253.
2. Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, Macera CA, Heath GW, Thompson PD, Bauman A,. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Circulation 2007; 116: 1081-1093.
3. Strath SJ, Kaminsky LA, Ainsworth BE, Ekelund U, Freedson PS, Gary RA, Richardson CR, Smith DT, Swartz AM,. Guide to the assessment of physical activity: clinical and research applications: a scientific statement from the American Heart Association. Circulation 2013; 128: 2259-2279.
4. James CA, Bhonsale A, Tichnell C, Murray B, Russell SD, Tandri H, Tedford RJ, Judge DP, Calkins H,. Exercise increases age-related penetrance and arrhythmic risk in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated desmosomal mutation carriers. J Am Coll Cardiol 2013; 62: 1290-1297.
5. Corrado D, Basso C, Rizzoli G, Schiavon M, Thiene G,. Does sports activity enhance the risk of sudden death in adolescents and young adults? J Am Coll Cardiol 2003; 42: 1959-1963.
6. Pelliccia A, Fagard R, Bjornstad HH, Anastassakis A, Arbustini E, Assanelli D, Biffi A, Borjesson M, Carre F, Corrado D, Delise P, Dorwarth U, Hirth A, Heidbuchel H, Hoffmann E, Mellwig KP, Panhuyzen-Goedkoop N, Pisani A, Solberg EE, van-Buuren F, Vanhees L, Blomstrom-Lundqvist C, Deligiannis A, Dugmore D, Glikson M, Hoff PI, Hoffmann A, Hoffmann E, Horstkotte D, Nordrehaug JE, Oudhof J, McKenna WJ, Penco M, Priori S, Reybrouck T, Senden J, Spataro A, Thiene G,. Recommendations for competitive sports participation in athletes with cardiovascular disease: a consensus document from the Study Group of Sports Cardiology of the Working Group of Cardiac Rehabilitation and Exercise Physiology and the Working Group of Myocardial and Pericardial Diseases of the European Society of Cardiology. Eur Heart J 2005; 26: 1422-1445.
7. Basso C, Corrado D, Bauce B, Thiene G,. Arrhythmogenic right ventricular cardiomyopathy. Circ Arrhythm Electrophysiol 2012; 5: 1233-1246.
8. Corrado D, Thiene G, Nava A, Rossi L, Pennelli N,. Sudden death in young competitive athletes: clinicopathologic correlations in 22 cases. Am J Med 1990; 89: 588-596.
9. Kirchhof P, Fabritz L, Zwiener M, Witt H, Schafers M, Zellerhoff S, Paul M, Athai T, Hiller KH, Baba HA, Breithardt G, Ruiz P, Wichter T, Levkau B,. Age- and training-dependent development of arrhythmogenic right ventricular cardiomyopathy in heterozygous plakoglobin-deficient mice. Circulation 2006; 114: 1799-1806.
10. Marcus FI, McKenna WJ, Sherrill D, Basso C, Bauce B, Bluemke DA, Calkins H, Corrado D, Cox MG, Daubert JP, Fontaine G, Gear K, Hauer R, Nava A, Picard MH, Protonotarios N, Saffitz JE, Sanborn DM, Steinberg JS, Tandri H, Thiene G, Towbin JA, Tsatsopoulou A, Wichter T, Zareba W,. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria. Circulation 2010; 121: 1533-1541.
11. Byrne NM, Hills AP, Hunter GR, Weinsier RL, Schutz Y,. Metabolic equivalent: one size does not fit all. J Appl Physiol 2005; 99: 1112-1119.
12. Mitchell JH, Haskell W, Snell P, Van Camp SP,. Task Force 8: classification of sports. J Am Coll Cardiol 2005; 45: 1364-1367.
13. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS, Solomon SD, Spencer KT, Sutton MS, Stewart WJ,. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005; 18: 1440-1463.
14. Rudski LG, Lai WW, Afilalo J, Hua L, Handschumacher MD, Chandrasekaran K, Solomon SD, Louie EK, Schiller NB,. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr 2010; 23: 685-713.
15. Haugaa KH, Amlie JP, Berge KE, Leren TP, Smiseth OA, Edvardsen T,. Transmural differences in myocardial contraction in long-QT syndrome: mechanical consequences of ion channel dysfunction. Circulation 2010; 122: 1355-1363.
16. Sarvari SI, Haugaa KH, Anfinsen OG, Leren TP, Smiseth OA, Kongsgaard E, Amlie JP, Edvardsen T,. Right ventricular mechanical dispersion is related to malignant arrhythmias: a study of patients with arrhythmogenic right ventricular cardiomyopathy and subclinical right ventricular dysfunction. Eur Heart J 2011; 32: 1089-1096.
17. Schulz-Menger J, Bluemke DA, Bremerich J, Flamm SD, Fogel MA, Friedrich MG, Kim RJ, von Knobelsdorff-Brenkenhoff F, Kramer CM, Pennell DJ, Plein S, Nagel E,. Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) board of trustees task force on standardized post processing. J Cardiovasc Magn Reson 2013; 15: 1-19.
18. Corrado D, Basso C, Rizzoli G, Schiavon M, Thiene G,. Does sports activity enhance the risk of sudden death in adolescents and young adults? J Am Coll Cardiol 2003; 42: 1959-1963.
19. La GA, Burns AT, Mooney DJ, Inder WJ, Taylor AJ, Bogaert J, Macisaac AI, Heidbuchel H, Prior DL,. Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes. Eur Heart J 2012; 33: 998-1006.
20. Aaron CP, Tandri H, Barr RG, Johnson WC, Bagiella E, Chahal H, Jain A, Kizer JR, Bertoni AG, Lima JA, Bluemke DA, Kawut SM,. Physical activity and right ventricular structure and function. The MESA-Right Ventricle Study. Am J Respir Crit Care Med 2011; 183: 396-404.
21. Pelliccia A, Maron MS, Maron BJ,. Assessment of left ventricular hypertrophy in a trained athlete: differential diagnosis of physiologic athlete's heart from pathologic hypertrophy. Prog Cardiovasc Dis 2012; 54: 387-396.
22. Simsek Z, Hakan TM, Degirmenci H, Gokhan YA, Ipek E, Duman H, Gundogdu F, Karakelleoglu S, Senocak H,. Speckle tracking echocardiographic analysis of left ventricular systolic and diastolic functions of young elite athletes with eccentric and concentric type of cardiac remodeling. Echocardiography 2013; 30: 1202-1208.
23. Teske AJ, Prakken NH, De Boeck BW, Velthuis BK, Martens EP, Doevendans PA, Cramer MJ,. Echocardiographic tissue deformation imaging of right ventricular systolic function in endurance athletes. Eur Heart J 2009; 30: 969-977.
24. King G, Almuntaser I, Murphy RT, La GA, Mahoney N, Bennet K, Clarke J, Brown A,. Reduced right ventricular myocardial strain in the elite athlete may not be a consequence of myocardial damage. 'Cream masquerades as skimmed milk'. Echocardiography 2013; 30: 929-935.
25. Heidbuchel H, Hoogsteen J, Fagard R, Vanhees L, Ector H, Willems R, Van LJ,. High prevalence of right ventricular involvement in endurance athletes with ventricular arrhythmias. Role of an electrophysiologic study in risk stratification. Eur Heart J 2003; 24: 1473-1480.
26. La GA, Robberecht C, Kuiperi C, Nuyens D, Willems R, de RT, Matthijs G, Heidbuchel H,. Lower than expected desmosomal gene mutation prevalence in endurance athletes with complex ventricular arrhythmias of right ventricular origin. Heart 2010; 96: 1268-1274.
27. Heidbuchel H, Prior DL, La GA,. Ventricular arrhythmias associated with long-term endurance sports: what is the evidence? Br J Sports Med 2012; 46 (Suppl 1): i44-i50.
28. Aaron CP, Tandri H, Barr RG, Johnson WC, Bagiella E, Chahal H, Jain A, Kizer JR, Bertoni AG, Lima JA, Bluemke DA, Kawut SM,. Physical activity and right ventricular structure and function. The MESA-Right Ventricle Study. Am J Respir Crit Care Med 2011; 183: 396-404.
29. Zaidi A, Ghani S, Sharma R, Oxborough D, Panoulas VF, Sheikh N, Gati S, Papadakis M, Sharma S,. Physiological right ventricular adaptation in elite athletes of African and Afro-Caribbean origin. Circulation 2013; 127: 1783-1792.