Colon and endometrial cancers with mismatch repair deficiency can arise from somatic, rather than germline, mutations

Gastroenterology

Volumn 147, Issue 6, 2014, Pages 1308-1316.e1

  Haraldsdottir, Sigurdis ^a   Hampel, Heather ^a   Tomsic, Jerneja ^a   Frankel, Wendy L ^a   Pearlman, Rachel ^a   De La Chapelle, Albert ^a   Pritchard, Colin C ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Colon Cancer; dMMR; Genomic Instability; MSI

Indexed keywords

B RAF KINASE; EPITHELIAL CELL ADHESION MOLECULE; EXONUCLEASE; GENOMIC DNA; MISMATCH REPAIR PROTEIN PMS2; POLE PROTEIN; PROTEIN; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE; CELL ADHESION MOLECULE; DNA BINDING PROTEIN; DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE GAMMA; DNA LIGASE; EPCAM PROTEIN, HUMAN; G-T MISMATCH-BINDING PROTEIN; MLH1 PROTEIN, HUMAN; MSH2 PROTEIN, HUMAN; NUCLEAR PROTEIN; PMS2 PROTEIN, HUMAN; POLD1 PROTEIN, HUMAN; POLE PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR ANTIGEN;

ADULT; AGE; AGED; AMINO ACID SEQUENCE; ARTICLE; CANCER DIAGNOSIS; CANCER SCREENING; CLINICAL ARTICLE; COHORT ANALYSIS; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE SURVEILLANCE; DNA METHYLATION; DNA SEQUENCE; ENDOMETRIUM CANCER; EXON; FALSE POSITIVE RESULT; FEMALE; FRAMESHIFT MUTATION; GENE AMPLIFICATION; GENE MUTATION; GENE SEQUENCE; GENETIC COUNSELING; GENETIC SCREENING; GERMLINE MUTATION; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HETEROZYGOSITY LOSS; HUMAN; IMMUNOHISTOCHEMISTRY; INDEL MUTATION; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; MISMATCH REPAIR; MUTATION RATE; NONSENSE MUTATION; PHENOTYPE; PROMOTER REGION; SOMATIC MUTATION; VERY ELDERLY; COLON TUMOR; ENDOMETRIUM TUMOR; GENETICS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOSINE TRIPHOSPHATASES; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, NEOPLASM; CELL ADHESION MOLECULES; COLONIC NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA MISMATCH REPAIR; DNA POLYMERASE II; DNA POLYMERASE III; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; ENDOMETRIAL NEOPLASMS; FEMALE; GERM-LINE MUTATION; HUMANS; MALE; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUTS HOMOLOG 2 PROTEIN; NUCLEAR PROTEINS;

EID: 84913584766     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.08.041     Document Type: Article

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