Endogenous leptin contributes to baroreflex suppression within the solitary tract nucleus of aged rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 307, Issue 11, 2014, Pages H1539-H1546

  Arnold, Amy C ^a   Diz, Debra I ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Arterial baroreflex; Autonomic; Leptin

Indexed keywords

CHLORALOSE; GLUCOSE; LEPTIN; LEPTIN RECEPTOR; PHENYLBIGUANIDE; PHENYLEPHRINE; RECOMBINANT LEPTIN; URETHAN; INSULIN; VASOCONSTRICTOR AGENT;

AGED; AGING; ARTICLE; BRADYCARDIA; CARDIOVASCULAR REFLEX; GLUCOSE BLOOD LEVEL; HEART RATE; HEMODYNAMICS; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRESSORECEPTOR REFLEX; PROTEIN BLOOD LEVEL; RAT; SOLITARY TRACT NUCLEUS; TACHYCARDIA; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; DRUG EFFECTS; PHYSIOLOGY; REFLEX; SPRAGUE DAWLEY RAT;

AGING; ANIMALS; BAROREFLEX; HEMODYNAMICS; INSULIN; LEPTIN; MALE; PHENYLEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LEPTIN; REFLEX; SOLITARY NUCLEUS; VASOCONSTRICTOR AGENTS;

EID: 84913558515     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00282.2014     Document Type: Article

References (45)

1. Ahren B, Mansson S, Gingerich RL, Havel PJ. Regulation of plasma leptin in mice: influence of age, high-fat diet, and fasting. Am J Physiol Regul Integr Comp Physiol273: R113–R120, 1997.
2. Andresen MC, Kunze DL. Nucleus tractus solitarius–gateway to neural circulatory control. Annu Rev Physiol56: 93–116, 1994.
3. Arnold AC, Sakima A, Ganten D, Ferrario CM, Diz DI. Modulation of reflex function by endogenous angiotensins in older transgenic rats with low glial angiotensinogen. Hypertension51: 1326–1331, 2008.
4. Arnold AC, Shaltout HA, Gallagher PE, Diz DI. Leptin impairs car-diovagal baroreflex function at the level of the solitary tract nucleus. Hypertension54: 1001–1008, 2009.
5. Bunag RD, Eriksson L, Krizsan D. Baroreceptor reflex impairment and mild hypertension in rats with dietary-induced obesity. Hypertension15: 397–406, 1990.
6. Campagnole-Santos MJ, Diz DI, Ferrario CM. Baroreceptor reflex modulation by angiotensin II at the nucleus tractus solitarii. Hypertension11: I167–I171, 1988.
7. Campagnole-Santos MJ, Diz DI, Santos RA, Khosla MC, Brosnihan KB, Ferrario CM. Cardiovascular effects of angiotensin-(1–7) injected into the dorsal medulla of rats. Am J Physiol Heart Circ Physiol257: H324–H329, 1989.
8. Chaves GZ, Caligiorne SM, Santos RA, Khosla MC, Campagnole-Santos MJ. Modulation of the baroreflex control of heart rate by angio-tensin-(1–7) at the nucleus tractus solitarii of normotensive and spontaneously hypertensive rats. J Hypertens18: 1841–1848, 2000.
9. Ciriello J, Moreau JM. Leptin signaling in the nucleus of the solitary tract alters the cardiovascular responses to activation of the chemoreceptor reflex. Am J Physiol Regul Integr Comp Physiol303: R727–R736, 2012.
10. Davidow LW, Schmitz TM, Bunag RD. Aging enhances serotonergic cardiovascular blockade by ketanserin in conscious rats. Aging (Milano)6: 239–248, 1994.
11. de Lartigue G, Barbier de la Serre C, Espero E, Lee J, Raybould HE. Diet-induced obesity leads to the development of leptin resistance in vagal afferent neurons. Am J Physiol Endocrinol Metab301: E187–E195, 2011.
12. Diz DI, Fantz DL, Benter IF, Bosch SM. Acute depressor actions of angiotensin II in the nucleus of the solitary tract are mediated by substance P. Am J Physiol Regul Integr Comp Physiol273: R28–R34, 1997.
13. Fauvel JP, Cerutti C, Mpio I, Ducher M. Aging process on spectrally determined spontaneous baroreflex sensitivity: a 5-year prospective study. Hypertension50: 543–546, 2007.
14. Fernandez-Galaz C, Fernandez-Agullo T, Campoy F, Arribas C, Gallardo N, Andres A, Ros M, Carrascosa JM. Decreased leptin uptake in hypothalamic nuclei with ageing in Wistar rats. J Endocrinol171: 23–32, 2001.
15. Ferrari AU, Radaelli A, Centola M. Invited review: aging and the cardiovascular system. J Appl Physiol (1985)95: 2591–2597, 2003.
16. Fow JE, Averill DB, Barnes KL. Mechanisms of angiotensin-induced hypotension and bradycardia in the medial solitary tract nucleus. Am J Physiol Heart Circ Physiol267: H259–H266, 1994.
17. Grassi G, Cattaneo BM, Seravalle G, Lanfranchi A, Mancia G. Baroreflex control of sympathetic nerve activity in essential and secondary hypertension. Hypertension31: 68–72, 1998.
18. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science269: 543–546, 1995.
19. Inyushkin AN, Inyushkina EM, Merkulova NA. Respiratory responses to microinjections of leptin into the solitary tract nucleus. Neurosci Behav Physiol39: 231–240, 2009.
20. Itoh H, Bunag RD. Age-related reduction of reflex bradycardia in conscious rats by catecholaminergic nucleus tractus solitarius lesions. Mech Ageing Dev67: 47–63, 1993.
21. Kasparov S, Paton JF. Differential effects of angiotensin II in the nucleus tractus solitarii of the rat–plausible neuronal mechanism. J Physiol521: 227–238, 1999.
22. Kasper SO, Carter CS, Ferrario CM, Ganten D, Ferder LF, Sonntag WE, Gallagher PE, Diz DI. Growth, metabolism, and blood pressure disturbances during aging in transgenic rats with altered brain renin-angiotensin systems. Physiol Genomics23: 311–317, 2005.
23. Kasper SO, Ferrario CM, Ganten D, Diz DI. Rats with low brain angiotensinogen do not exhibit insulin resistance during early aging. Endocrine30: 167–174, 2006.
24. Korner PI. Cardiac baroreflex in hypertension: role of the heart and angiotensin II. Clin Exp Hypertens17: 425–439, 1995.
25. La Rovere MT, Pinna GD, Maestri R, Sleight P. Clinical value of baroreflex sensitivity. Neth Heart J21: 61–63, 2013.
26. La Rovere MT, Pinna GD, Raczak G. Baroreflex sensitivity: measurement and clinical implications. Ann Noninvasive Electrocardiol13: 191–207, 2008.
27. Lim K, Burke SL, Head GA. Obesity-related hypertension and the role of insulin and leptin in high-fat-fed rabbits. Hypertension61: 628–634, 2013.
28. Mark AL. Selective leptin resistance revisited. Am J Physiol Regul Integr Comp Physiol305: R566–R581, 2013.
29. Mark AL, Agassandian K, Morgan DA, Liu X, Cassell MD, Rah-mouni K. Leptin signaling in the nucleus tractus solitarii increases sympathetic nerve activity to the kidney. Hypertension53: 375–380, 2009.
30. Matsumura K, Averill DB, Ferrario CM. Angiotensin II acts at AT1 receptors in the nucleus of the solitary tract to attenuate the baroreceptor reflex. Am J Physiol Regul Integr Comp Physiol275: R1611–R1619, 1998.
31. Mercer JG, Moar KM, Hoggard N. Localization of leptin receptor (Ob-R) messenger ribonucleic acid in the rodent hindbrain. Endocrinology139: 29–34, 1998.
32. Monahan KD, Dinenno FA, Seals DR, Clevenger CM, DeSouza CA, Tanaka H. Age-associated changes in cardiovagal baroreflex sensitivity are related to central arterial compliance. Am J Physiol Heart Circ Physiol281: H284–H289, 2001.
33. Morrison CD, White CL, Wang Z, Lee SY, Lawrence DS, Cefalu WT, Zhang ZY, Gettys TW. Increased hypothalamic protein tyrosine phos-phatase 1B contributes to leptin resistance with age. Endocrinology148: 433–440, 2007.
34. Paton JF. Convergence properties of solitary tract neurones driven syn-aptically by cardiac vagal afferents in the mouse. J Physiol508: 237–252, 1998.
35. Rahmouni K. Leptin-induced sympathetic nerve activation: signaling mechanisms and cardiovascular consequences in obesity. Curr Hypertens Rev6: 104–209, 2010.
36. Sakima A, Averill DB, Gallagher PE, Kasper SO, Tommasi EN, Ferrario CM, Diz DI. Impaired heart rate baroreflex in older rats: role of endogenous angiotensin-(1–7) at the nucleus tractus solitarii. Hypertension46: 333–340, 2005.
37. Sakima A, Averill DB, Kasper SO, Jackson L, Ganten D, Ferrario CM, Gallagher PE, Diz DI. Baroreceptor reflex regulation in anesthetized transgenic rats with low glia-derived angiotensinogen. Am J Physiol Heart Circ Physiol292: H1412–H1419, 2007.
38. Sanchez-Rodriguez M, Garcia-Sanchez A, Retana-Ugalde R, Men-doza-Nunez VM. Serum leptin levels and blood pressure in the overweight elderly. Arch Med Res31: 425–428, 2000.
39. Scarpace PJ, Matheny M, Moore RL, Tumer N. Impaired leptin responsiveness in aged rats. Diabetes49: 431–435, 2000.
40. Schaich CL, Thomas BF, Grabenauer MA, Howlett AC, Diz DI. Blockade of CB1 receptors reveals that elevated medullary endocannabi-noids contribute to age-related impairment of baroreflex sensitivity in Sprague-Dawley rats (Abstract). FASEB J28: 681.4, 2014.
41. Su N, Narayanan N. Age related alteration in cholinergic but not alpha adrenergic response of rat coronary vasculature. Cardiovasc Res27: 284–290, 1993.
42. Thayer JF, Lane RD. The role of vagal function in the risk for cardiovascular disease and mortality. Biol Psychol74: 224–242, 2007.
43. Tumer N, Erdos B, Matheny M, Cudykier I, Scarpace PJ. Leptin antagonist reverses hypertension caused by leptin overexpression, but fails to normalize obesity-related hypertension. J Hypertens25: 2471–2478, 2007.
44. Young CN, Morgan DA, Butler SD, Mark AL, Davisson RL. The brain subfornical organ mediates leptin-induced increases in renal sympathetic activity but not its metabolic effects. Hypertension61: 737–744, 2013.
45. Zhang J, Matheny MK, Tumer N, Mitchell MK, Scarpace PJ. Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent. Am J Physiol Regul Integr Comp Physiol292: R868–R874, 2007.