Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis

Journal of Allergy and Clinical Immunology

Volumn 134, Issue 5, 2014, Pages 1084-1092.e1

  Alexander, Eileen S ^a,b   Martin, Lisa J ^a   Collins, Margaret H ^a   Kottyan, Leah C ^a   Sucharew, Heidi ^a   He, Hua ^a   Mukkada, Vincent A ^a   Succop, Paul A ^a   Abonia, J Pablo ^a   Foote, Heather ^a   Eby, Michael D ^a   Grotjan, Tommie M ^a   Greenler, Alexandria J ^a   Dellon, Evan S ^c   Demain, Jeffrey G ^d   Furuta, Glenn T ^e   Gurian, Larry E ^f   Harley, John B ^a,g   Hopp, Russell J ^h   Kagalwalla, Amir ^i,j   Kaul, Ajay ^a   Nadeau, Kari C ^k,l   Noel, Richard J ^m,n   Putnam, Philip E ^a   Von Tiehl, Karl F ^o   Rothenberg, Marc E ^a   more..

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b XAVIER UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d Allergy Asthma and Immunology Center of Alaska   (United States)

^e UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^f Ferrell Duncan Clinic   (United States)

^g VETERANS AFFAIRS MEDICAL CENTER   (United States)

^h CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ CHILDREN'S MEMORIAL HOSPITAL   (United States)

^j NORTHWESTERN UNIVERSITY   (United States)

^k STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^l LUCILE PACKARD CHILDREN S HOSPITAL   (United States)

^m Children's Hospital of Wisconsin   (United States)

ⁿ MEDICAL COLLEGE OF WISCONSIN   (United States)

^o HUNTINGTON MEMORIAL HOSPITAL   (United States)

more..

Author keywords

drug hypersensitivity; Eosinophilia; food allergy; gastrointestinal diseases; gene environment interaction; heritability; immune system diseases; medical genetics; skin diseases; twins

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; AUTUMN; BIRTH WEIGHT; BREAST FEEDING; CHILD; CLUSTER ANALYSIS; COHORT ANALYSIS; DIZYGOTIC TWINS; ENVIRONMENT; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; EOSINOPHILIC ESOPHAGITIS; FAMILY HISTORY; FAMILY STUDY; FATHER; FEMALE; FIRST DEGREE RELATIVE; FOOD ALLERGY; GENE CLUSTER; GENE FREQUENCY; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE ENVIRONMENT INTERACTION; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOZYGOTIC TWINS; MOTHER; MULTIPLE PREGNANCY; NUCLEAR FAMILY; PENICILLIN ALLERGY; PHENOTYPE; RECURRENCE RISK; RECURRENT DISEASE; RISK ASSESSMENT; SEASONAL VARIATION; SEX DIFFERENCE; SIBLING; TWIN CONCORDANCE; TWIN DISCORDANCE; TWINS; CASE CONTROL STUDY; CLINICAL TRIAL; CONTROLLED STUDY; FAMILY; GENETICS; IMMUNOLOGY; INFANT; MIDDLE AGED; MULTICENTER STUDY; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; EOSINOPHILIC ESOPHAGITIS; FAMILY; FEMALE; GENE-ENVIRONMENT INTERACTION; HUMANS; INFANT; MALE; MIDDLE AGED; RISK FACTORS; SEX FACTORS; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 84913554107     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.07.021     Document Type: Article

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