Effect of intracervical anesthesia on pain associated with the insertion of the levonorgestrel-releasing intrauterine system in women without previous vaginal delivery: A RCT

Human Reproduction

Volumn 29, Issue 11, 2014, Pages 2439-2445

  Castro, T V B ^a   Franceschini, S A ^a   Poli Neto, O ^a   Ferriani, R A ^a,b   Silva De Sa M F ^a,b   Vieira, C S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b National Institute of Hormones and Women's Health   (Brazil)

Author keywords

anesthesia; levonorgestrel releasing intrauterine system; nulliparous; pain

Indexed keywords

IBUPROFEN; LEVONORGESTREL; LIDOCAINE; MISOPROSTOL; LOCAL ANESTHETIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT;

ADULT; ANESTHESIA; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FACIAL PAIN SCALE; FEMALE; HUMAN; INTRACERVICAL ANESTHESIA; LEVONORGESTREL RELEASING INTRAUTERINE SYSTEM; MAJOR CLINICAL STUDY; NULLIPARA; OPEN STUDY; PAIN ASSESSMENT; PELVIS PAIN SYNDROME; RANDOMIZED CONTROLLED TRIAL; RISK; VAGINAL DELIVERY; VISUAL ANALOG SCALE; ADVERSE EFFECTS; DRUG EFFECTS; INTRAUTERINE CONTRACEPTIVE DEVICE; MIDDLE AGED; PAIN; PAIN MEASUREMENT; TREATMENT OUTCOME; UTERINE CERVIX;

ADULT; ANESTHETICS, LOCAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CERVIX UTERI; FEMALE; HUMANS; INTRAUTERINE DEVICES, MEDICATED; LEVONORGESTREL; LIDOCAINE; MIDDLE AGED; PAIN; PAIN MEASUREMENT; TREATMENT OUTCOME;

EID: 84913539999     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/deu233     Document Type: Article

References (33)

1. ACOG Committee Opinion. Intrauterine device and adolescents. Obstet Gynecol 2007;110:1493-1495.
2. Allen RH, Bartz D, Grimes DA, Hubacher D, O'Brien P. Interventions for pain with intrauterine device insertion. The Cochrane Library 2009, Issue 3. Review.
3. Allen RH, Raker C, Goyal V. Higher dose cervical 2% lidocaine gel for IUD insertion: a randomized controlled trial. Contraception 2013;88:730-736.
4. Aoun J, Dines VA, StovallDW, Mete M, Nelson CB, Gomez-Lobo V. Effects of age, parity, and device type on complications and discontinuation of intrauterine devices. Obstet Gynecol 2014;123:585-592.
5. Bahamondes MV, Hidalgo MM, Bahamondes L, Monteiro I. Ease of insertion and clinical performance of the levonorgestrel-releasing intrauterine system in nulligravidas. Contraception 2011;84:e11-e16.
6. Botega NJ, Bio MR, Zomignani MA, GarciaCJr, PereiraWA. Mood disorders among inpatients in ambulatory and validation of the anxiety and depression scale HAD. Rev Saude Publica 1995;29:355-363.
7. Chor J, Bregand-White J, Golobof A, Harwood B, Cowett A. Ibuprofen prophylaxis for levonorgestrel-releasing intrauterine system insertion: a randomized controlled trial. Contraception 2012;6:558-562.
8. Espey E, Singh RH, Leeman L, OgburnT, Fowler K, Greene H. Misoprostol for intrauterine device insertion in nulliparous women: a randomized controlled trial. Am J Obstet Gynecol 2014;210:208.e1-5.
9. Farrar JT. Advances in clinical research methodology for pain clinical trials. Nat Med 2010;16:1284-1293.
10. Gemzell-Danielsson K, Mansour D, Fiala C, Kaunitz AM, Bahamondes L. Management of pain associated with the insertion of intrauterine contraceptives. Hum Reprod Update 2013;19:419-427.
11. Grimes DA. Forgettable contraception. Contraception 2009;80:497-499.
12. Heikinheimo O, Gemzell-Danielsson K. Emerging indications for the levonorgestrel-releasing intrauterine system (LNG-IUS). Acta Obstet Gynecol Scand 2012;91:3-9.
13. Heikinheimo O, Inkib P, Kunzb M, Parmhedc S, Anttilad AN, Olssone SE, Hurskainenf R, Danielssong KG. Double-blind, randomized, placebo-controlled study on the effect of misoprostol on ease of consecutive insertion of the levonorgestrel-releasing intrauterine system. Contraception 2010;81:481-486.
14. Hubacher D, Reyes V, Lillo S, Zepeda A, Chen PL, Croxatto H. Pain from copper intrauterine device insertion: randomized trial of prophylactic ibuprofen. Am J Obstet Gynecol 2006;195:1272-1277.
15. Karabayirli S, Ayrim AA, Muslu B. Comparison of the analgesic effects of oral tramadol and naproxen sodium on pain relief during IUD insertion. J Minim Invasive Gynecol 2012;19:581-584.
16. Lathrop E, Haddad L, McWhorter CP, Goedken P. Self-administration of misoprostol prior to intrauterine device insertion among nulliparous women: a randomized controlled trial. Contraception 2013;88:725-729.
17. Lyus R, Lohr P, Prager S. Board of the Society of Family Planning. Use of the Mirena LNG-IUS and Paragard CuT380A intrauterine devices in nulliparous women. Contraception 2010;81:367-371.
18. Mansour D, Gemzell-Danielsson K, Inki P, Jensen JT. Fertility after discontinuation of contraception: a comprehensive review of the literature. Contraception 2011;84:465-477.
19. Marions L, Lovkist L, Taube A, Johansson M, Dalvik H, Overlie I. Use of the levonorgestrel releasing-intrauterine system in nulliparous women - a non-interventional study in Sweden. Eur J Contracept Reprod Health Care 2011;16:126-134.
20. McNicholas CP, Madden T, Zhao Q, Secura G, Allsworth JE, Peipert JF. Cervical lidocaine for IUD insertional pain: a randomized controlled trial. Am J Obstet Gynecol 2012;207:384.e1-6.
21. Ministério da Saúde do Brasil (Health Ministry of Brazil). A Dor como 58 sinal vital. Registo sistemático da intensidade da Dor [Pain as the 5th vital sign. Systematic recording of pain intensity]. Circular Normativa n8 9/DGCG of 6/14/2003. http://www.dgs.pt/directrizes-da-dgs/normas-e-circulares-normativas/circular-normativa-n-9dgcg-de-140620 03.aspx.
22. Mody SK, Kiley J, Rademaker A, Gawron L, Stika C, Hammond C. Pain control for intrauterine device insertion: a randomized trial of 1% lidocaine paracervical block. Contraception 2012;86:704-709.
23. Murty J. Use and effectiveness of oral analgesia when fitting an intrauterine device. J Fam Plann Reprod Health Care 2003;29:150-151.
24. Nelson AL, Fong JK. Intrauterine infusion of lidocaine does not reduce pain scores during IUD insertion. Contraception 2013;88:37-40.
25. Prager S, Darney PD. The levonorgestrel intrauterine system in nulliparous women. Contraception 2007;75:12-15.
26. Saav I, Aronsson A, Marions L, Stephansson O, Gemzell-Danielsson K. Cervical priming with sublingual misoprostol prior to insertion of an intrauterine device in nulliparous women: a randomized controlled trial. Hum Reprod 2007;22:2647-2652.
27. Santos ARG, Bahamondes MV, Hidalgo MM, Atti A, Bahamondes L, Monteiro L. Pain at insertion of the levonorgestrel-releasing intrauterine system in nulligravida and parous women with and without cesarean section. Contraception 2013;88:164-168.
28. Shimoni N. Intrauterine contraceptives: a review of uses, side effects, and candidates. Semin Reprod Med 2010;28:118-125.
29. Suhonen S, Haukkamaa M, Jakobsson T, Rauramo I. Clinical performance of a levonorgestrel-releasing intrauterine systemandoral contraceptives in young nulliparous women: a comparative study. Contraception 2004;69:407-412.
30. Swenson C, Turok DK,Ward K, Jacobson JC, Dermish A. Self-administered misoprostol or placebo before intrauterine device insertion in nulliparous women: a randomized controlled trial. Obstet Gynecol 2012;120(2 Pt 1): 341-347.
31. Trussell J. Contraceptive failure in the United States. Contraception 2011; 83:397-404.
32. Winner B, Peipert JF, Zhao Q, Buckel C, Madden T, Allsworth JE, SecuraGM. Effectiveness of long-acting reversible contraception. N Engl J Med 2012; 21:1998-2007.
33. World Health Organization. Medical eligibility criteria for contraceptive use, 4th edn. Geneva: World Health Organization, 2009. http://whqlibdoc. who.int/publications/2010/9789241563888-eng.pdf.