Perioperative enteral immunonutrition modulates systemic and mucosal immunity and the inflammatory response in patients with periampullary cancer scheduled for pancreaticoduodenectomy: A randomized clinical trial

Pancreas

Volumn 44, Issue 1, 2015, Pages 41-52

  Hamza, Numan ^a,b,c,d   Darwish, Ammar ^b,d   O'Reilly, Derek A ^a,d   Denton, John ^d   Sheen, Aali J ^b   Chang, David ^c   Sherlock, David J ^a   Ammori, Basil J ^a,b,d  

^a NORTH MANCHESTER GENERAL HOSPITAL   (United Kingdom)

^b MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^c ROYAL BLACKBURN HOSPITAL   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Immunonutrition; Malnutrition; Pancreaticoduodenectomy; Periampullary cancer

Indexed keywords

CD20 ANTIGEN; CD3 ANTIGEN; CD57 ANTIGEN; CD68 ANTIGEN; COMPLEMENT; INTERLEUKIN 1ALPHA; TUMOR NECROSIS FACTOR; AUTACOID; CYTOKINE; ALPHA TOCOPHEROL; ARGININE; CALCIUM; CARBOHYDRATE; CHLORIDE; CHROMIUM; COPPER; FLUORINE; IODINE; IRON; LACTOSE; MAGNESIUM; MANGANESE; MOLYBDENUM; NICOTINIC ACID; OMEGA 3 FATTY ACID; PHOSPHORUS; POTASSIUM; PYRIDOXINE; RETINOL; RIBOFLAVIN; RNA; SELENIUM; SODIUM; THIAMINE; TUMOR NECROSIS FACTOR ALPHA; VITAMIN D; VITAMIN K GROUP; ZINC;

ADULT; AGED; AMPULLA OF VATER; ARTICLE; CALORIC INTAKE; CANCER IMMUNOLOGY; CANCER PATIENT; CANCER SURGERY; CD4 CD8 RATIO; CLINICAL ARTICLE; COMPARATIVE EFFECTIVENESS; COMPLEMENT SYSTEM; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY COMPLIANCE; DUODENUM BIOPSY; DUODENUM CANCER; ENTERAL IMMUNONUTRITION; ENTERIC FEEDING; FEMALE; HUMAN; IMMUNE SYSTEM; INFLAMMATION; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MALE; MUCOSAL IMMUNITY; MULTICENTER STUDY; PANCREATICODUODENECTOMY; PERIOPERATIVE PERIOD; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; TREATMENT DURATION; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; DUODENAL NEOPLASMS; DUODENUM; ENGLAND; IMMUNOCOMPROMISED PATIENT; IMMUNOLOGY; INTESTINE MUCOSA; MALNUTRITION; MIDDLE AGED; NUTRITIONAL ASSESSMENT; NUTRITIONAL STATUS; PANCREATIC NEOPLASMS; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; TIME FACTOR; TREATMENT OUTCOME; TUMOR ESCAPE; AGE; BILE DUCT CARCINOMA; BLEEDING; BLOOD TRANSFUSION; BODY MASS; ENERGY; FIBER; GENDER; HUMAN TISSUE; INTERMETHOD COMPARISON; JAUNDICE; KARNOFSKY PERFORMANCE STATUS; LEUKOCYTE COUNT; LYMPHOCYTE; MACROPHAGE; MAST CELL; NUTRITIONAL PARAMETERS; OPERATION DURATION; PANCREAS CANCER; PERIAMPULLARY CANCER; PREOPERATIVE PERIOD; STANDARD ENTERAL NUTRITION; WEIGHT REDUCTION;

AGED; CD4-CD8 RATIO; COMPLEMENT SYSTEM PROTEINS; CYTOKINES; DUODENAL NEOPLASMS; DUODENUM; ENGLAND; ENTERAL NUTRITION; FEMALE; HUMANS; IMMUNITY, MUCOSAL; IMMUNOCOMPROMISED HOST; INFLAMMATION MEDIATORS; INTESTINAL MUCOSA; LYMPHOCYTE SUBSETS; MALE; MALNUTRITION; MIDDLE AGED; NUTRITION ASSESSMENT; NUTRITIONAL STATUS; PANCREATIC NEOPLASMS; PANCREATICODUODENECTOMY; PERIOPERATIVE CARE; PROSPECTIVE STUDIES; TIME FACTORS; TREATMENT OUTCOME; TUMOR ESCAPE;

EID: 84913534278     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0000000000000222     Document Type: Article

References (43)

1. Fortner JG, Kim DK, Hopkins L, et al. Immunologic function in patients with carcinoma of the pancreas. Surg Gynecol Obstet. 1980;150: 215-218.
2. Funa K, Nilsson B, Jacobsson G, et al. Decreased natural killer cell activity and interferon production by leucocytes in patientswith adenocarcinoma of the pancreas. Br J Cancer. 1984;50:231-233.
3. Monson JR, Guillou PJ. Immunological perspectives on pancreatic cancer and jaundice. Hepatogastroenterology. 1989;36:437-441.
4. Wigmore SJ, Ross JA, Falconer JS, et al. The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. Nutrition. 1996;12:S27-S30.
5. Poch B, Lotspeich E, Ramadani M, et al. Systemic immune dysfunction in pancreatic cancer patients. Langenbecks Arch Surg. 2007;392: 353-358.
6. Wigmore SJ, Fearon KCH, Maingay JP, et al. Down-regulation of the acute phase response in patients with pancreatic cancer cachexia receiving oral eicosapentaenoic acid is mediated via suppression of interleukin-6. Clin Sci. 1997;92:215-221.
7. Wigmore SJ, Plester CE, Richardson RA, et al. Changes in nutritional status associated with unresectable pancreatic cancer. Br J Cancer. 1997; 75:106-109.
8. Riso S, Aluffi P, Brugnani M, et al. Postoperative enteral immunonutrition in head and neck cancer patients. Clin Nutr. 2000;19:407-412.
9. Skipworth RJ, Fearon KC. The scientific rationale for optimizing nutritional support in cancer. Eur J Gastroenterol Hepatol. 2007;19: 371-377.
10. O'Flaherty L, Bouchier-Hayes DJ. Immunonutrition and surgical practice. Proc Nutr Soc. 1999;58:831-837.
11. Stratton RJ, Hackston A, Longmore D, et al. Malnutrition in hospital outpatients and inpatients: prevalence, concurrent validity and ease of use of the 'malnutrition universal screening tool' ('MUST') for adults. Br J Nutr. 2004;92:799-808.
12. Gianotti L, Braga M, Fortis C, et al. A prospective, randomized clinical trial on perioperative feeding with an arginine-, omega-3 fatty acid-, and RNA-enriched enteral diet: effect on host response and nutritional status. JPEN. 1999;23:314-320.
13. Watters JM, Kirkpatrick SM, Norris SB, et al. Immediate postoperative enteral feeding results in impaired respiratory mechanics and decreased mobility. Ann Surg. 1997;226:369-377.
14. National Kidney Foundation Kidney Disease Outcomes Quality Initiative Guidelines. 2000. Available at: https://www. kidney. org/professionals/kdoqi/guidelines-updates/nut-a10. html, appendix VIII.
15. Gianotti L, Braga M, Nespoli L, et al. A randomized controlled trial of preoperative oral supplementation with a specialized diet in patients with gastrointestinal cancer. Gastroenterology. 2002;122:1763-1770.
16. Braga M, Gianotti L, Vignali A, et al. Preoperative oral arginine and n-3 fatty acid supplementation improves the immunometabolic host response and outcome after colorectal resection for cancer. Surgery. 2002;132: 805-814.
17. Braga M, Gianotti L, Nespoli L, et al. Nutritional approach inmalnourished surgical patients: a prospective randomized study. Arch Surg. 2002;137: 174-180.
18. Di Carlo V, Gianotti L, Balzano G, et al. Complications of pancreatic surgery and the role of perioperative nutrition. Dig Surg. 1999;16: 320-326.
19. Slotwinski R, Olszewski WL, Slotkowski M, et al. Can the interleukin-1 receptor antagonist (IL-1ra) be a marker of anti-inflammatory response to enteral immunonutrition in malnourished patients after pancreaticoduodenectomy? JOP. 2007;8:759-769.
20. Slotwinski R, Olszewski W, Slodkowski M, et al. Apoptosis in lymphocytes of pancreatic cancer patients: influence of preoperative enteral immunonutrition and extensive surgery. Arch Immunol Ther Exp (Warsz). 2011;59:385-397.
21. Shirakawa H, Kinoshita T, Gotohda N, et al. Compliance with and effects of preoperative immunonutrition in patients undergoing pancreaticoduodenectomy. J Hepatobiliary Pancreat Sci. 2012;19: 249-258.
22. Suzuki D, Furukawa K, Kimura F, et al. Effects of perioperative immunonutrition on cell-mediated immunity, T helper type 1 (TH1)/TH2 differentiation, and TH17 response after pancreaticoduodenectomy. Surgery. 2010;148:573-581.
23. van Bokhorst-de van der Schueren MA, Quak JJ, von Blomberg-van der Flier BM, et al. Effect of perioperative nutrition, with and without arginine supplementation, on nutritional status, immune function, postoperative morbidity, and survival in severely malnourished head and neck cancer patients. Am J Clin Nutr. 2001;73:323-332.
24. Potter J, Langhorne P, Roberts M. Routine protein energy supplementation in adults: systematic review. BMJ. 1998;317:495-501.
25. Wigmore SJ, BarberMD, Ross JA. Effect of oral eicosapentaenoic acid on weight loss in patients with pancreatic cancer. Nutr Cancer. 2000;36: 177-184.
26. Xu J, Zhong Y, Jing D, et al. Preoperative enteral immunonutrition improves postoperative outcome in patients with gastrointestinal cancer. World J Surg. 2006;30:1284-1289.
27. Gunerhan Y, Koksal N, Sahin UY, et al. Effect of preoperative immunonutrition and other nutrition models on cellular immune parameters. World J Gastroenterol. 2009;15:467-472.
28. Tsujinaka T, Hirao M, Fujitani K, et al. Effect of preoperative immunonutrition on body composition in patients undergoing abdominal cancer surgery. Surg Today. 2007;37:118-121.
29. Slade MS, Simmons RL, Yumis E, et al. Immunodepression after major surgery in normal patients. Surgery. 1975;78:363-372.
30. Klek S, Sierzega M, Szybinski P, et al. The immunomodulating enteral nutrition in malnourished surgical patients - a prospective, randomized, double-blind clinical trial. Clin Nutr. 2011;30: 282-288.
31. Zheng Y, Li F, Qi B, et al. Application of perioperative immunonutrition for gastrointestinal surgery: a meta-analysis of randomized controlled trials. Asia Pac J Clin Nutr. 2007;16:253-257.
32. Cheadle WG, Pemberton RM, Robinson D, et al. Lymphocyte subset responses to trauma and sepsis. J Trauma. 1993;35:844-849.
33. Finco C, Magnanini P, Sarzo G, et al. Prospective randomized study on perioperative enteral immunonutrition in laparoscopic colorectal surgery. Surg Endosc. 2007;21:1175-1179.
34. Endres S. Messengers and mediators: interactions among lipids, eicosanoids, and cytokines. Am J Clin Nutr. 1993;57:798S-800S.
35. McCarter MD, Gentilini OD, Gomez ME, et al. Preoperative oral supplement with immunonutrients in cancer patients. JPEN. 1998;22: 206-211.
36. Zhang J, Koh J, Lu J, et al. Local inflammation induces complement crosstalk which amplifies the antimicrobial response. PLoS Pathog. 2009; 5:e1000282.
37. Heideman M, Saravis C, Clowes GH Jr. Effect of nonviable tissue and abscesses on complement depletion and the development of bacteremia. J Trauma. 1982;22:527-532.
38. Welsh FK, Farmery SM, MacLennan K, et al. Gut barrier function in malnourished patients. Gut. 1998;42:396-401.
39. Reynolds JV, O'Farrelly C, Feighery C, et al. Impaired gut barrier function in malnourished patients. Br J Surg. 1996;83:1288-1291.
40. Kragballe K, Voorhees JJ, Goetzl EJ. Inhibition by leukotriene B5 of leukotriene B4-induced activation of human keratinocytes and neutrophils. J InvestDermatol. 1987;88:555-558.
41. Wachtler P, König W, Senkal M, et al. Influence of a total parenteral nutrition enriched with omega-3 fatty acids on leukotriene synthesis of peripheral leukocytes and systemic cytokine levels in patients with major surgery. J Trauma. 1997;42:191-198.
42. Wachtler P, Axel Hilger R, König W, et al. Influence of a pre-operative enteral supplement on functional activities of peripheral leukocytes from patients with major surgery. Clin Nutr. 1995;14:275-282.
43. O'Callaghan G, Beale RJ. The role of immune-enhancing diets in the management of perioperative patients. Crit Care Resusc. 2003;5: 277-283.