High-sensitivity C-reactive protein is an independent risk factor for non-vertebral fractures in women and men: The Tromsø Study

Bone

Volumn 72, Issue , 2015, Pages 65-70

  Dahl, Kristoffer ^a   Ahmed, Luai Awad ^a   Joakimsen, Ragnar Martin ^a,b   Jørgensen, Lone ^a   Eggen, Anne Elise ^a   Eriksen, Erik Fink ^c   Bjørnerem, Åshild ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Bone mineral density; Gender differences; Hs CRP; Non vertebral fracture

Indexed keywords

C REACTIVE PROTEIN;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BODY HEIGHT; BODY MASS; BONE DENSITY; DISEASE ASSOCIATION; FEMALE; FEMUR NECK FRACTURE; FOLLOW UP; HIGH RISK PATIENT; HIP FRACTURE; HUMAN; HUMERUS FRACTURE; MAJOR CLINICAL STUDY; MALE; PREDICTION; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; RISK FACTOR; SEX DIFFERENCE; SEX RATIO; WRIST FRACTURE; BLOOD; FRACTURES, BONE; INFLAMMATION; METABOLISM; MIDDLE AGED; NORWAY; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; QUESTIONNAIRE; SENSITIVITY AND SPECIFICITY;

AGED; BONE DENSITY; C-REACTIVE PROTEIN; FEMALE; FRACTURES, BONE; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; NORWAY; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; QUESTIONNAIRES; RISK FACTORS; SENSITIVITY AND SPECIFICITY; SEX FACTORS;

EID: 84913529809     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2014.11.012     Document Type: Article

References (45)

1. Cummings S.R., Melton L.J. Epidemiology and outcomes of osteoporotic fractures. Lancet 2002, 359:1761-1767.
2. Kanis J.A., Oden A., Johnell O., De Laet C., Jonsson B., Oglesby A.K. The components of excess mortality after hip fracture. Bone 2003, 32:468-473.
3. Bjørnerem Å., Straume B., Midtby M., Fønnebø V., Sundsfjord J., Svartberg J., et al. Endogenous sex hormones in relation to age, sex, lifestyle factors, and chronic diseases in a general population: the Tromso Study. J Clin Endocrinol Metab 2004, 89:6039-6047.
4. Bjørnerem Å., Ahmed L.A., Joakimsen R.M., Berntsen G.K., Fønnebø V., Jørgensen L., et al. A prospective study of sex steroids, sex hormone-binding globulin, and non-vertebral fractures in women and men: the Tromso Study. Eur J Endocrinol 2007, 157:119-125.
5. Seeman E. Age- and menopause-related bone loss compromise cortical and trabecular microstructure. J Gerontol A Biol Sci Med Sci 2013, 68:1218-1225.
6. Kanis J.A., Johnell O., Oden A., Sembo I., Redlund-Johnell I., Dawson A., et al. Long-term risk of osteoporotic fracture in Malmö. Osteoporos Int 2000, 11:669-674.
7. Kannegaard P.N., van der Mark S., Eiken P., Abrahamsen B. Excess mortality in men compared with women following a hip fracture. National analysis of comedications, comorbidity and survival. Age Ageing 2010, 39:203-209.
8. Gough A.K., Lilley J., Eyre S., Holder R.L., Emery P. Generalised bone loss in patients with early rheumatoid arthritis. Lancet 1994, 344:23-27.
9. Danesh J., Wheeler J.G., Hirschfield G.M., Eda S., Eiriksdottir G., Rumley A., et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med 2004, 350:1387-1397.
10. Kaptoge S., Di Angelantonio E., Lowe G., Pepys M.B., Thompson S.G., Collins R., et al. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet 2010, 375:132-140.
11. Dehghan A., van Hoek M., Sijbrands E.J., Stijnen T., Hofman A., Witteman J.C. Risk of type 2 diabetes attributable to C-reactive protein and other risk factors. Diabetes Care 2007, 30:2695-2699.
12. Jahnsen J., Falch J.A., Mowinckel P., Aadland E. Bone mineral density in patients with inflammatory bowel disease: a population-based prospective two-year follow-up study. Scand J Gastroenterol 2004, 39:145-153.
13. Spector T.D., Hall G.M., McCloskey E.V., Kanis J.A. Risk of vertebral fracture in women with rheumatoid arthritis. BMJ 1993, 306:558.
14. Schett G., Kiechl S., Weger S., Pederiva A., Mayr A., Petrangeli M., et al. High-sensitivity C-reactive protein and risk of nontraumatic fractures in the Bruneck study. Arch Intern Med 2006, 166:2495-2501.
15. Koh J.M., Khang Y.H., Jung C.H., Bae S., Kim D.J., Chung Y.E., et al. Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis. Osteoporos Int 2005, 16:1263-1271.
16. Ding C., Parameswaran V., Udayan R., Burgess J., Jones G. Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study. J Clin Endocrinol Metab 2008, 93:1952-1958.
17. Nakamura K., Saito T., Kobayashi R., Oshiki R., Oyama M., Nishiwaki T., et al. C-reactive protein predicts incident fracture in community-dwelling elderly Japanese women: the Muramatsu study. Osteoporos Int 2011, 22:2145-2150.
18. Pasco J.A., Kotowicz M.A., Henry M.J., Nicholson G.C., Spilsbury H.J., Box J.D., et al. High-sensitivity C-reactive protein and fracture risk in elderly women. JAMA 2006, 296:1353-1355.
19. Cauley J.A., Danielson M.E., Boudreau R.M., Forrest K.Y., Zmuda J.M., Pahor M., et al. Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study. J Bone Miner Res 2007, 22:1088-1095.
20. Rolland T., Boutroy S., Vilayphiou N., Blaizot S., Chapurlat R., Szulc P. Poor trabecular microarchitecture at the distal radius in older men with increased concentration of high-sensitivity C-reactive protein--the STRAMBO study. Calcif Tissue Int 2012, 90:496-506.
21. Ishii S., Cauley J.A., Greendale G.A., Crandall C.J., Danielson M.E., Ouchi Y., et al. C-reactive protein, bone strength, and nine-year fracture risk: data from the Study of Women's Health Across the Nation (SWAN). J Bone Miner Res 2013, 28:1688-1698.
22. Ahmadi-Abhari S., Luben R.N., Wareham N.J., Khaw K.T. C-reactive protein and fracture risk: European Prospective Investigation into Cancer Norfolk Study. Bone 2013, 56:67-72.
23. Eriksson A.L., Moverare-Skrtic S., Ljunggren Ö., Karlsson M., Mellström D., Ohlsson C. High-sensitivity CRP is an independent risk factor for all fractures and vertebral fractures in elderly men: the MrOS Sweden≥study. J Bone Miner Res 2014, 29:418-423.
24. Oei L., Campos-Obando N., Dehghan A., Oei E.H., Stolk L., van Meurs J.B., et al. Dissecting the relationship between high-sensitivity serum C-reactive protein and increased fracture risk: the Rotterdam Study. Osteoporos Int 2014, 25:1247-1254.
25. Parfitt A.M., Mathews C.H., Villanueva A.R., Kleerekoper M., Frame B., Rao D.S. Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss. J Clin Invest 1983, 72:1396-1409.
26. Clowes J.A., Riggs B.L., Khosla S. The role of the immune system in the pathophysiology of osteoporosis. Immunol Rev 2005, 208:207-227.
27. Bertolini D.R., Nedwin G.E., Bringman T.S., Smith D.D., Mundy G.R. Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors. Nature 1986, 319:516-518.
28. Jacobsen B.K., Eggen A.E., Mathiesen E.B., Wilsgaard T., Njølstad I. Cohort profile: the Tromsø Study. Int J Epidemiol 2012, 41:961-967.
29. Emaus N., Omsland T.K., Ahmed L.A., Grimnes G., Sneve M., Berntsen G.K. Bone mineral density at the hip in Norwegian women and men-prevalence of osteoporosis depends on chosen references: the Tromsø Study. Eur J Epidemiol 2009, 24:321-328.
30. Ahmed L.A., Center J.R., Bjørnerem A., Bluic D., Joakimsen R.M., Jørgensen L., et al. Progressively increasing fracture risk with advancing age after initial incident fragility fracture: the Tromsø study. J Bone Miner Res 2013, 28:2214-2221.
31. Bjørnerem Å., Ahmed L.A., Jørgensen L., Størmer J., Joakimsen R.M. Breastfeeding protects against hip fracture in postmenopausal women: the Tromsø study. J Bone Miner Res 2011, 26:2843-2850.
32. Joakimsen R.M., Fønnebø V., Søgaard A.J., Tollan A., Størmer J., Magnus J.H. The Tromsø study: registration of fractures, how good are self-reports, a computerized radiographic register and a discharge register?. Osteoporos Int 2001, 12:1001-1005.
33. Joakimsen R.M., Fønnebo V., Magnus J.H., Størmer J., Tollan A., Søgaard A.J. The Tromsø Study: physical activity and the incidence of fractures in a middle-aged population. J Bone Miner Res 1998, 13:1149-1157.
34. Joakimsen R.M., Fønnebø V., Magnus J.H., Tollan A., Søgaard A.J. The Tromsø Study: body height, body mass index and fractures. Osteoporos Int 1998, 8:436-442.
35. Nardi R., Scanelli G., Corrao S., Iori I., Mathieu G., Cataldi Amatrian R. Co-morbidity does not reflect complexity in internal medicine patients. Eur J Intern Med 2007, 18:359-368.
36. Cohen P.G. Aromatase, adiposity, aging and disease. The hypogonadal-metabolic-atherogenic-disease and aging connection. Med Hypotheses 2001, 56:702-708.
37. Halvorsen D.S., Johnsen S.H., Mathiesen E.B., Njølstad I. The association between inflammatory markers and carotid atherosclerosis is sex dependent: the Tromso Study. Cerebrovasc Dis 2009, 27:392-397.
38. Jørgensen L., Joakimsen O., Mathiesen E.B., Ahmed L., Berntsen G.K., Fønnebø V., et al. Carotid plaque echogenicity and risk of nonvertebral fractures in women: a longitudinal population-based study. Calcif Tissue Int 2006, 79:207-213.
39. Jørgensen L., Joakimsen O., Rosvold Berntsen G.K., Heuch I., Jacobsen B.K. Low bone mineral density is related to echogenic carotid artery plaques: a population-based study. Am J Epidemiol 2004, 160:549-556.
40. Baker-LePain J.C., Nakamura M.C., Lane N.E. Effects of inflammation on bone: an update. Curr Opin Rheumatol 2011, 23:389-395.
41. Pacifici R. The immune system and bone. Arch Biochem Biophys 2010, 503(1):41-53.
42. Kim B.J., Yu Y.M., Kim E.N., Chung Y.E., Koh J.M., Kim G.S. Relationship between serum hsCRP concentration and biochemical bone turnover markers in healthy pre- and postmenopausal women. Clin Endocrinol (Oxf) 2007, 67:152-158.
43. Bjørnerem A., Ghasem-Zadeh A., Bui M., Wang X., Rantzau C., Nguyen T.V., et al. Remodeling markers are associated with larger intracortical surface area but smaller trabecular surface area: a twin study. Bone 2011, 49:1125-1130.
44. Pasceri V., Willerson J.T., Yeh E.T. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 2000, 102:2165-2168.
45. Barbour K.E., Boudreau R., Danielson M.E., Youk A.O., Wactawski-Wende J., Greep N.C., et al. Inflammatory markers and the risk of hip fracture: the Women's Health Initiative. J Bone Miner Res 2012, 27:1167-1176.