Remodeling markers are associated with larger intracortical surface area but smaller trabecular surface area: A twin study

Bone

Volumn 49, Issue 6, 2011, Pages 1125-1130

  Bjørnerem, Åshild ^a   Ghasem Zadeh, Ali ^b   Bui, Minh ^b   Wang, Xiaofang ^b   Rantzau, Christian ^c   Nguyen, Tuan V ^d   Hopper, John L ^b   Zebaze, Roger ^b   Seeman, Ego ^b  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Bone remodeling; Bone surfaces; Intracortical porosity; Menopause; Twins

Indexed keywords

ADULT; ARTICLE; BODY MASS; BONE; BONE MASS; BONE REMODELING; BONE STRUCTURE; CONTROLLED STUDY; ENDOCORTICAL BONE; FEMALE; HUMAN; INTRACORTICAL BONE; POROSITY; POSTMENOPAUSE; PREMENOPAUSE; RADIUS; SURFACE PROPERTY; TIBIA; TRABECULAR BONE; TWINS;

ADULT; BIOLOGICAL MARKERS; BONE REMODELING; COLLAGEN TYPE I; FEMALE; HUMANS; MIDDLE AGED; OSTEOCALCIN; PEPTIDE FRAGMENTS; PEPTIDES; POSTMENOPAUSE; PREMENOPAUSE; PROCOLLAGEN; RADIUS; SURFACE PROPERTIES; TIBIA; TWINS;

EID: 81355137915     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2011.08.009     Document Type: Article

References (33)

1. Parfitt A.M. Skeletal heterogeneity and the purposes of bone remodelling: implications for the understanding of osteoporosis. Osteoporosis 2008, 71-89. Academic, San Diego, CA. R. Marcus, D. Feldman, D.A. Nelson, C.J. Rosen (Eds.).
2. Parfitt A.M. Targeted and non-targeted bone remodeling: relationship to basic multicellular unit origination and progression. Bone 2002, 30:5-7.
3. Parfitt A.M. The physiologic and clinical significance of bone histomorphometric data. Bone Histomorphometry. Techniques and Interpretstion 1983, 142-223. CRC Press, Boca Raton. R. Recker (Ed.).
4. Seeman E., Delmas P.D. Bone quality-the material and structural basis of bone strength and fragility. N Engl J Med 2006, 354:2250-2261.
5. Eriksen E.F., Langdahl B., Vesterby A., Rungby J., Kassem M. Hormone replacement therapy prevents osteoclastic hyperactivity: a histomorphometric study in early postmenopausal women. J Bone Miner Res 1999, 14:1217-1221.
6. Manolagas S.C. Choreography from the tomb: an emerging role of dying osteocytes in the purposeful, and perhaps not so purposeful, targeting of bone remodeling. BoneKEy 2006, 3:5-14.
7. Garnero P., Sornay-Rendu E., Chapuy M.C., Delmas P.D. Increased bone turnover in late postmenopausal women is a major determinant of osteoporosis. J Bone Miner Res 1996, 11:337-349.
8. Ebeling P.R., Atley L.M., Guthrie J.R., Burger H.G., Dennerstein L., Hopper J.L., et al. Bone turnover markers and bone density across the menopausal transition. J Clin Endocrinol Metab 1996, 81:3366-3371.
9. Cauley J.A., Lui L.Y., Barnes D., Ensrud K.E., Zmuda J.M., Hillier T.A., et al. Successful skeletal aging: a marker of low fracture risk and longevity. The study of osteoporotic fractures (SOF). J Bone Miner Res 2009, 24:134-143.
10. Szulc P., Seeman E., Duboeuf F., Sornay-Rendu E., Delmas P.D. Bone fragility: failure of periosteal apposition to compensate for increased endocortical resorption in postmenopausal women. J Bone Miner Res 2006, 21:1856-1863.
11. van Daele P.L., Seibel M.J., Burger H., Hofman A., Grobbee D.E., van Leeuwen J.P., et al. Case-control analysis of bone resorption markers, disability, and hip fracture risk: the Rotterdam study. BMJ 1996, 312:482-483.
12. Garnero P., Mulleman D., Munoz F., Sornay-Rendu E., Delmas P.D. Long-term variability of markers of bone turnover in postmenopausal women and implications for their clinical use: the OFELY study. J Bone Miner Res 2003, 18:1789-1794.
13. Garnero P., Sornay-Rendu E., Duboeuf F., Delmas P.D. Markers of bone turnover predict postmenopausal forearm bone loss over 4years: the OFELY study. J Bone Miner Res 1999, 14:1614-1621.
14. Hauge E.M., Qvesel D., Eriksen E.F., Mosekilde L., Melsen F. Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markers. J Bone Miner Res 2001, 16:1575-1582.
15. Modder U.I., Khosla S. Skeletal stem/osteoprogenitor cells: current concepts, alternate hypotheses, and relationship to the bone remodeling compartment. J Cell Biochem 2008, 103:393-400.
16. Laib A., Hauselmann H.J., Ruegsegger P. In vivo high resolution 3D-QCT of the human forearm. Technol Health Care 1998, 6:329-337.
17. Lorensen W.E., Cline H.E. Marching cubes: a high resolution 3D surface construction algorithm. Comput Graphics 1987, 21:163-169.
18. Liang K.Y., Zeger S.L. Longitudinal data analysis using generalized linear models. Biometrica 1986, 73:13-22.
19. Burton P., Gurrin L., Sly P. Extending the simple linear regression model to account for correlated responses: an introduction to generalized estimating equations and multi-level mixed modelling. Stat Med 1998, 17:1261-1291.
20. Hopper J.L., Seeman E. The bone density of female twins discordant for tobacco use. N Engl J Med 1994, 330:387-392.
21. Macinnis R.J., Cassar C., Nowson C.A., Paton L.M., Flicker L., Hopper J.L., et al. Determinants of bone density in 30- to 65-year-old women: a co-twin study. J Bone Miner Res 2003, 18:1650-1656.
22. R: A language and environment for statistical computing 2009, R Development Core Team, R Foundation for Statistical Computing, Vienna, Austria, URL. http://www.R-project.org/.
23. Carey Vincent J. Ported to R by Thomas Lumley (versions 3.13, 4.4) and Brian Ripley (version 4.13). (2009). gee: Generalized Estimation Equation solver. R package version 4.13-14. 2009. URL http://CRAN.R-project.org/package=gee.
24. Martin R.B. Porosity and specific surface of bone. Crit Rev Biomed Eng 1984, 10:179-222.
25. Emerton K.B., Hu B., Woo A.A., Sinofsky A., Hernandez C., Majeska R.J., et al. Osteocyte apoptosis and control of bone resorption following ovariectomy in mice. Bone 2010, 46:577-583.
26. Parfitt A.M. Misconceptions (2): turnover is always higher in cancellous than in cortical bone. Bone 2002, 30:807-809.
27. Han Z.H., Palnitkar S., Rao D.S., Nelson D., Parfitt A.M. Effects of ethnicity and age or menopause on the remodeling and turnover of iliac bone: implications for mechanisms of bone loss. J Bone Miner Res 1997, 12:498-508.
28. Han Z.H., Palnitkar S., Rao D.S., Nelson D., Parfitt A.M. Effect of ethnicity and age or menopause on the structure and geometry of iliac bone. J Bone Miner Res 1996, 11:1967-1975.
29. Zebaze R.M., Ghasem-Zadeh A., Bohte A., Iuliano-Burns S., Mirams M., Price R.I., et al. Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study. Lancet 2010, 375:1729-1736.
30. Riggs B.L., Khosla S., Melton L.J. A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res 1998, 13:763-773.
31. Riggs B.L., Melton I.L., Robb R.A., Camp J.J., Atkinson E.J., Peterson J.M., et al. Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites. J Bone Miner Res 2004, 19:1945-1954.
32. Khosla S., Melton L.J., Riggs B.L. The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: is a revision needed?. J Bone Miner Res 2011, 26:441-451.
33. Zebaze R, Ghasem-Zadeh A, Seeman, E. Method and system for Image Analyses of Selected Tissue Structures International Patent Application No. PCT/AU2010/001181. 2011. http://www.wipo.int/pctdb/en/wo.jsp?WO=2011029153.