The association between inflammatory markers and carotid atherosclerosis is sex dependent: The Tromsø study

Cerebrovascular Diseases

Volumn 27, Issue 4, 2009, Pages 392-397

  Halvorsen, Dag S ^a   Johnsen, Stein H ^a,b   Mathiesen, Ellisiv B ^a,b   Njølstad, Inger ^b  

^a UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^b UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Carotid atherosclerosis; Inflammation; Plaque echolucency

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; C REACTIVE PROTEIN; FIBRINOGEN;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR RISK; CAROTID ARTERY; CAROTID ATHEROSCLEROSIS; CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GRAY SCALE ECHOGRAPHY; HUMAN; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MORPHOLOGY; PRIORITY JOURNAL; SEX DIFFERENCE;

AGED; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CAROTID ARTERY DISEASES; CAROTID STENOSIS; CROSS-SECTIONAL STUDIES; FEMALE; FIBRINOGEN; HEALTH SURVEYS; HUMANS; LEUKOCYTE COUNT; LINEAR MODELS; LOGISTIC MODELS; MALE; MIDDLE AGED; NORWAY; RISK FACTORS; SEX CHARACTERISTICS;

EID: 61649097505     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000207443     Document Type: Article

References (36)

1. Hansson GK: Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005; 352: 1685-1695.
2. Elkind MS, Cheng J, Boden-Albala B, Paik MC, Sacco RL: Elevated white blood cell count and carotid plaque thickness: the northern Manhattan stroke study. Stroke 2001; 32: 842-849.
3. Martinez-Vila E, Paramo JA, Beloqui O, Orbe J, Irimia P, Colina I, Monreal I, Benito A, Barba J, Zubieta JL, Diez J: Independent association of fibrinogen with carotid intima-media thickness in asymptomatic subjects. Cerebrovasc Dis 2003; 16: 356-362.
4. Makita S, Nakamura M, Hiramori K: The association of C-reactive protein levels with carotid intima-media complex thickness and plaque formation in the general population. Stroke 2005; 36: 2138-2142.
5. Chapman CM, Beilby JP, McQuillan BM, Thompson PL, Hung J: Monocyte count, but not C-reactive protein or interleukin-6, is an independent risk marker for subclinical carotid atherosclerosis. Stroke 2004; 35: 1619-1624.
6. Wang TJ, Nam BH, Wilson PW, Wolf PA, Levy D, Polak JF, D'Agostino RB, O'Donnell CJ: Association of C-reactive protein with carotid atherosclerosis in men and women: the Framingham heart study. Arterioscler Thromb Vasc Biol 2002; 22: 1662-1667.
7. Lee CD, Folsom AR, Nieto FJ, Chambless LE, Shahar E, Wolfe DA: White blood cell count and incidence of coronary heart disease and ischemic stroke and mortality from cardiovascular disease in African-American and white men and women: atherosclerosis risk in communities study. Am J Epidemiol 2001; 154: 758-764.
8. Danesh J, Lewington S, Thompson SG, et al: Fibrinogen Studies Collaboration: Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA 2005; 294: 1799-1809.
9. Rost NS, Wolf PA, Kase CS, Kelly-Hayes M, Silbershatz H, Massaro JM, D'Agostino RB, Franzblau C, Wilson PWF: Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: the Framingham study. Stroke 2001; 32: 2575-2579.
10. Koenig W, Khuseyinova N, Baumert J, Thorand B, Loewel H, Chambless L, Meisinger C, Schneider A, Martin S, Kolb H, Herder C: Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women. Arterioscler Thromb Vasc Biol 2006; 26: 2745-2751.
11. Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M, Fadl YY, Fortmann SP, Hong Y, Myers GL, Rifai N, Smith SC, Taubert K, Tracy RP, Vinicor F: Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 2003; 107: 499-511.
12. Di Napoli M, Schwaninger M, Cappelli R, Ceccarelli E, Gianfilippo GD, Donati C, Emsley HCA, Forconi S, Hopkins SJ, Masotti L, Muir KW, Paciucci A, Papa F, Roncacci S, Sander D, Sander K, Smith CJ, Stafanini A, Weber D: Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for health care professionals from the CRP pooling project members. Stroke 2005; 36: 1316-1329.
13. Nordestgaard BG, Gronholdt ML, Sillesen H: Echolucent rupture-prone plaques. Curr Opin Lipidol 2003; 14: 505-512.
14. Mathiesen EB, Bonaa KH, Joakimsen O: Echolucent plaques are associated with high risk of ischemic cerebrovascular events in carotid stenosis: the Tromsø study. Circulation 2001; 103: 2171-2175.
15. Honda O, Sugiyama S, Kugiyama K, Fukushima H, Nakamura S, Koide S, Kojima S, Hirai N, Kawano H, Soejima H, Sakamoto T, Yoshimura M, Ogawa H: Echolucent carotid plaques predict future coronary events in patients with coronary artery disease. J Am Coll Cardiol 2004; 43: 1177-1184.
16. Yamashiro K, Watanabe T, Tanaka R, Komine-Kobayashi M, Mizuno Y, Urabe T: Clustering of risk factors increases the incidence of echolucent carotid plaque in stroke patients. Cerebrovasc Dis 2006; 22: 432-438.
17. Yamagami H, Kitagawa K, Nagai Y, Hougaku H, Sakaguchi M, Kuwabara K, Kondo K, Masuyama T, Matsumoto M, Hori M: Higher levels of interleukin-6 are associated with lower echogenicity of carotid artery plaques. Stroke 2004; 35: 677-681.
18. Kofoed SC, Wittrup HH, Sillesen H, Nordestgaard BG: Fibrinogen predicts ischaemic stroke and advanced atherosclerosis but not echolucent, rupture-prone carotid plaques: the Copenhagen City Heart Study. Eur Heart J 2003; 24: 567-576.
19. Fosse E, Johnsen SH, Stensland-Bugge E, Joakimsen O, Mathiesen EB, Arnesen E, Njølstad I: Repeated visual and computerassisted carotid plaque characterization in a longitudinal population-based ultrasound study: the Tromsø study. Ultrasound Med Biol 2006; 32: 3-11.
20. Johnsen SH, Fosse E, Joakimsen O, Mathiesen EB, Stensland-Bugge E, Njølstad I, Arnesen E: Monocyte count is a predictor of novel plaque formation: a 7-year follow-up study of 2610 persons without carotid plaque at baseline. The Tromsø study. Stroke 2005; 36: 715-719.
21. Corti R, Fuster V, Badimon JJ: Pathogenetic concepts of acute coronary syndromes. J Am Coll Cardiol 2003; 41(suppl 4S):7S-14S.
22. Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V: Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 2000; 148: 209-214.
23. Davison S, Davis SR: New markers for cardiovascular disease risk in women: impact of endogenous estrogen status and exogenous postmenopausal hormone therapy. J Clin Endocrinol Metab 2003; 88: 2470-2478.
24. Danesh J, Wheeler JG, Hirschfield GM, Eda S, Eiriksdottir G, Rumley A, Lowe GDO, Pepys MB, Gudnason V: C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med 2004; 350: 1387-1397.
25. Bots MJ, Schipper CMA, Koudstaal PJ, Witteman JCM, Hofman A, Breteler MMB: High serum C-reactive protein level is not an independent predictor for stroke: the Rotterdam study. Circulation 2006; 114: 1591-1598.
26. Blankenberg S, Yusuf S: The inflammatory hypothesis: any progress in risk stratification and therapeutic targets? Circulation 2006; 114: 1557-1560.
27. Blackburn R, Giral P, Bruckert E, Andre JM, Gonbert S, Bernard M, Chapman MJ, Turpin G: Elevated C-reactive protein constitutes an independent predictor of advanced carotid plaques in dyslipidemic subjects. Arterioscler Thromb Vasc Biol 2001; 21: 1962-1968.
28. Folsom AR, Golden SH, Boland LL, Szklo M: Association of endogenous hormones with C-reactive protein, fibrinogen and white blood cell count in post-menopausal women. Eur J Epidemiol 2005; 20: 1015-1022.
29. Rossouw JE: Hormones, genetic factors, and gender differences in cardiovascular disease. Cardiovasc Res 2002; 53: 550-557.
30. Khera A, McGuire DK, Murphy SA, Stanek HG, Das SR, Vongpatanasin W, Wians FH Jr, Grundy SM, de Lemos JA: Race and gender differences in C-reactive protein levels. J Am Coll Cardiol 2005; 46: 464-469.
31. Lakoski SG, Cushman M, Criqui M, Rundek T, Blumenthal RS, D'Agostino RB Jr, Herrington DM: Gender and C-reactive protein: data from the Multiethnic Study of Atherosclerosis (MESA) cohort. Am Heart J 2006; 152: 593-598.
32. Kritchevsky SB, Cesari M, Pahor M: Inflammatory markers and cardiovascular health in older adults. Cardiovasc Res 2005; 66: 265-275.
33. Kamath S, Lip GYH: Fibrinogen: biochemistry, epidemiology and determinants. Q J Med 2003; 96: 711-729.
34. Spence JD: Technology insight: ultrasound measurement of carotid plaque-patient management, genetic research, and therapy evaluation. Nat Clin Pract Neurol 2006; 2: 611-619.
35. Johnsen SH, Mathiesen EB, Joakimsen O, Stensland E, Wilsgaard T, Løchen ML, Njølstad I, Arnesen E: Carotid atherosclerosis is a stronger predictor of myocardial infarction in women than in men: a 6-year follow-up study in 6226 persons: The Tromsø study. Stroke 2007; 38: 2873-2880.
36. El Barghouty NM, Levine T, Ladva S, Flanagen A, Nicolaides A: Histopathological verification of computerized carotid plaque characterisation. Eur J Vasc Endovasc Surg 1996; 11: 414-416.