Properties of AdeABC and AdeIJK efflux systems of Acinetobacter baumannii compared with those of the AcrAB-TolC system of Escherichia coli

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 12, 2014, Pages 7250-7257

  Sugawara, Etsuko ^a   Nikaido, Hiroshi ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROMYCIN; ETHIDIUM BROMIDE; NOVOBIOCIN; TETRACYCLINE; ACRA PROTEIN, E COLI; ACRB PROTEIN, E COLI; ADEA PROTEIN, ACINETOBACTER BAUMANNII; ADEB PROTEIN, ACINETOBACTER BAUMANNII; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAM; BETA LACTAMASE; CARRIER PROTEIN; ESCHERICHIA COLI PROTEIN; ETHIDIUM; LIPOPROTEIN; MULTIDRUG RESISTANCE PROTEIN; OUTER MEMBRANE PROTEIN; RECOMBINANT PROTEIN; TOLC PROTEIN, E COLI;

ACINETOBACTER BAUMANNII; ACRAB TOLC SYSTEM; ADEABC EFFLUX SYSTEM; ADEIJK EFFLUX SYSTEM; ARTICLE; CONTROLLED STUDY; ESCHERICHIA COLI; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION SYSTEM; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DYNAMICS; NONHUMAN; PROMOTER REGION; COMPARATIVE STUDY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC COMPLEMENTATION; GENETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; MULTIDRUG RESISTANCE;

ACINETOBACTER BAUMANNII; ANTI-BACTERIAL AGENTS; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; BETA-LACTAMASES; BETA-LACTAMS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ERYTHROMYCIN; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; ETHIDIUM; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC COMPLEMENTATION TEST; LIPOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICROBIAL SENSITIVITY TESTS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NOVOBIOCIN; RECOMBINANT PROTEINS; TETRACYCLINE;

EID: 84912554793     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.03728-14     Document Type: Article

References (20)

1. Bonomo RA, Szabo D. 2006. Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa. Clin. Infect. Dis. 43(Suppl 2):S49 -S56. http://dx.doi.org/10.1086/504477.
2. Peleg AY, Seifer H, Paterson DL. 2008. Acinetobacter baumannii: emergence of successful pathogen. Clin. Microbiol. Rev. 21:538-582. http://dx .doi.org/10.1128/CMR.00058-07.
3. Sugawara E, Nikaido H. 2012. OmpA is the principal nonspecific slow porin of Acinetobacter baumannii. J. Bacteriol. 194:4089-4096. http://dx .doi.org/10.1128/JB.00435-12.
4. Sugawara E, Nikaido H. 2004. OmpA/OprF: slow porins or channels produced by alternative folding of outer membrane proteins, p 119-138. In BenzR(ed), Bacterial and eukaryotic porins: structure, function, mechanism. Wiley-VCH, Weinheim, Germany.
5. Nikaido H, Rosenberg EY, Foulds J. 1983. Porin channels in Escherichia coli: studies with β-lactams in intact cells. J. Bacteriol. 153:232-240.
6. Coyne SP, Courvalin P, Perichon B. 2011. Efflux-mediated antibiotic resistance in Acinetobacter spp. Antimicrob. Agents Chemother. 55:947-953. http://dx.doi.org/10.1128/AAC.01388-10.
7. Marchand I, Damier-Piolle L, Courvalin P, Lambert T. 2004. Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system. Antimicrob. Agents Chemother. 48:3298-3304. http://dx.doi.org/10.1128/AAC.48.9 .3298-3304.2004.
8. Nemec A, Marixnerova M, van der Reijden TJ, van den Broek PJ, Dijkshoorn L. 2007. Relationship between the AdeABC efflux system gene content, netilmicin susceptibility and multidrug resistance in a genotypically diverse collection of Acinetobacter baumannii strains. J. Antimicrob. Chemother. 60:483-489. http://dx.doi.org/10.1093/jac/dkm231.
9. Magnet S, Courvalin P, Lambert T. 2001. Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454. Antimicrob. Agents Chemother. 45: 3375-3380. http://dx.doi.org/10.1128/AAC.45.12.3375-3380.2001.
10. Damier-Piolle L, Magnet S, Bremont S, Lambert T, Courvalin P. 2008. AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. Antimicrob. Agents Chemother. 52: 557-562. http://dx.doi.org/10.1128/AAC.00732-07.
11. Nagano K, Nikaido H. 2009. Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 106: 5854-5858. http://dx.doi.org/10.1073/pnas.0901695106.
12. Lim SP, Nikaido H. 2010. Kinetic parameters of efflux of penicillins by the multidrug efflux transporter AcrAB-TolC of Escherichia coli. Antimicrob. Agents Chemother. 54:1800 -1806. http://dx.doi.org/10.1128 /AAC.01714-09.
13. Okusu H, Ma D, Nikaido H. 1996. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multipleantibiotic- resistance (Mar) mutants. J. Bacteriol. 178:306-308.
14. Sugawara E, Nestorovich EM, Bezrukov SM, Nikaido H. 2006. Pseudomonas aeruginosa porin OprF exists in two different conformations. J. Biol. Chem. 281:16220-16229. http://dx.doi.org/10.1074/jbc .M600680200.
15. Takeshita S, Sato M, Masahashi W, Hashimoto-Gotoh T. 1987. Highcopy- number and low-copy-number plasmid vectors for lacZ- complementation and chloramphenicol- or kanamycin-resistance selection. Gene 61:63-74. http://dx.doi.org/10.1016/0378-1119(87)90365-9.
16. Vargiu AV, Nikaido H. 2012. Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations. Proc. Natl. Acad. Sci. U. S. A. 109:20637-20642. http://dx.doi.org/10.1073/pnas .1218348109.
17. Maloney PC, Rotman B. 1973. Distribution of suboptimally induced-Dgalactosidase in Escherichia coli. The enzyme content of individual cells. J. Mol. Biol. 73:77-91.
18. Normark S, Burman LG. 1977. Resistance of Escherichia coli to penicillins: fine-structure mapping and dominance of chromosomal betalactamase mutations. J. Bacteriol. 132:1-7.
19. Nikaido H. 1996. Multidrug efflux pumps of gram-negative bacteria. J. Bacteriol. 178:5853-5859.
20. Aires JR, Nikaido H. 2005. Aminoglycosides are captured from both periplasm and cytoplasm by the AcrD multidrug efflux transporter of Escherichia coli. J. Bacteriol. 187:1923-1929. http://dx.doi.org/10.1128/JB .187.6.1923-1929.2005.