N4-monobutyryl-cCMP activates PKA RIα and PKA RIIα more potently and with higher efficacy than PKG Iα in vitro but not in vivo

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 387, Issue 12, 2014, Pages 1163-1175

  Wolter, Sabine ^a   Dove, Stefan ^b   Golombek, Marina ^a   Schwede, Frank ^c   Seifert, Roland ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c BIOLOG Life Science Institute   (Germany)

Author keywords

cAMP dependent protein kinase; cGMP dependent protein kinase; Cyclic CMP; Dibutyryl cCMP; N4 monobutyryl cCMP

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IALPHA; CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IIALPHA; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC CMP; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE 1; CYCLIC GMP DERIVATIVE; CYTIDINE DERIVATIVE; DIBUTYRYL CYCLIC GMP; DIBUTYRYLCYTIDINE 3',5' PHOSPHATE; ENZYME ACTIVATOR; N 4 MONOBUTYRYL CYTIDINE 3',5' CYCLIC MONOPHOSPHATE; UNCLASSIFIED DRUG; DIBUTYRYL CYCLIC-3',5'-CYTIDINE MONOPHOSPHATE; N4-MONOBUTYRYLCYTIDINE 3',5'-CYCLIC MONOPHOSPHATE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG EFFICACY; DRUG POTENCY; EC50; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOMA CELL; MOLECULAR MODEL; NUCLEOTIDE BINDING SITE; SECOND MESSENGER; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; VASODILATATION; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; COMPARATIVE STUDY; DRUG EFFECTS; LYMPHOMA; METABOLISM; MOUSE; PHOSPHORYLATION; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIALPHA SUBUNIT; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIIALPHA SUBUNIT; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC CMP; CYCLIC GMP-DEPENDENT PROTEIN KINASE TYPE I; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LYMPHOMA; MICE; MODELS, MOLECULAR; PHOSPHORYLATION;

EID: 84912550563     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-014-1042-9     Document Type: Article

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