T cell factor 1 represses CD8+ effector T cell formation and function

Journal of Immunology

Volumn 193, Issue 11, 2014, Pages 5480-5487

  Tiemessen, Machteld M ^a,b   Baert, Miranda R M ^a   Kok, Lianne ^a   Van Eggermond, Marja C J A ^a   Van Den Elsen, Peter J ^a   Arens, Ramon ^a   Staal, Frank J T ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b CRUCELL HOLLAND BV   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; BETA CATENIN; FRIZZLED PROTEIN; HERMES ANTIGEN; INTERLEUKIN 2; L SELECTIN; LYMPHOID ENHANCER FACTOR 1; PROTEIN BCL 6; TRANSCRIPTION FACTOR 7; TRANSCRIPTION FACTOR T BET; WNT PROTEIN; GAMMA INTERFERON; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HNF1A PROTEIN, HUMAN; PRDM1 PROTEIN, HUMAN; REPRESSOR PROTEIN; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21;

ALTERNATIVE RNA SPLICING; ARTICLE; CARBOXY TERMINAL SEQUENCE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELL MIGRATION; CONTROLLED STUDY; DNA METHYLATION; EFFECTOR CELL; FLOW CYTOMETRY; GENETIC TRANSCRIPTION; MEMORY CELL; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VIRUS LOAD; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOTOXICITY; GENE DOSAGE; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; METABOLISM; UPREGULATION; VIRUS INFECTION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; DNA METHYLATION; GENE DOSAGE; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; IMMUNOLOGIC MEMORY; INTERFERON-GAMMA; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN STABILITY; REPRESSOR PROTEINS; T-BOX DOMAIN PROTEINS; UP-REGULATION; VIRAL LOAD; VIRUS DISEASES;

EID: 84912544233     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1303417     Document Type: Article

References (35)

1. Williams, M. A., and M. J. Bevan. 2007. Effector and memory CTL differentiation. Annu. Rev. Immunol. 25: 171-192.
2. Arens, R., and S. P. Schoenberger. 2010. Plasticity in programming of effector and memory CD8 T-cell formation. Immunol. Rev. 235: 190-205.
3. Joshi, N. S., W. Cui, A. Chandele, H. K. Lee, D. R. Urso, J. Hagman, L. Gapin, and S. M. Kaech. 2007. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 27: 281-295.
4. + T cells. J. Exp. Med. 204: 2015-2021.
5. Rutishauser, R. L., G. A. Martins, S. Kalachikov, A. Chandele, I. A. Parish, E. Meffre, J. Jacob, K. Calame, and S. M. Kaech. 2009. Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. Immunity 31: 296-308.
6. + T cells to compete for the memory cell niche. J. Immunol. 185: 4988-4992.
7. + T cells. Eur. J. Immunol. 36: 3146-3156.
8. + T cells. Nat. Immunol. 12: 1230-1237.
9. Restifo, N. P., and L. Gattinoni. 2013. Lineage relationship of effector and memory T cells. Curr. Opin. Immunol. 25: 556-563.
10. Verbeek, S., D. Izon, F. Hofhuis, E. Robanus-Maandag, H. te Riele, M. van de Wetering, M. Oosterwegel, A. Wilson, H. R. MacDonald, and H. Clevers. 1995. An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature 374: 70-74.
11. Germar, K., M. Dose, T. Konstantinou, J. Zhang, H. Wang, C. Lobry, K. L. Arnett, S. C. Blacklow, I. Aifantis, J. C. Aster, and F. Gounari. 2011. T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling. Proc. Natl. Acad. Sci. USA 108: 20060-20065.
12. Weber, B. N., A. W. Chi, A. Chavez, Y. Yashiro-Ohtani, Q. Yang, O. Shestova, and A. Bhandoola. 2011. A critical role for TCF-1 in T-lineage specification and differentiation. Nature 476: 63-68.
13. Staal, F. J., T. C. Luis, and M. M. Tiemessen. 2008. WNT signalling in the immune system: WNT is spreading its wings. Nat. Rev. Immunol. 8: 581-593.
14. Staal, F. J., J. Meeldijk, P. Moerer, P. Jay, B. C. van de Weerdt, S. Vainio, G. P. Nolan, and H. Clevers. 2001. Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Eur. J. Immunol. 31: 285-293.
15. Pongracz, J. E., S. M. Parnell, T. Jones, G. Anderson, and E. J. Jenkinson. 2006. Overexpression of ICAT highlights a role for catenin-mediated canonical Wnt signalling in early T cell development. Eur. J. Immunol. 36: 2376-2383.
16. Weerkamp, F., M. R. Baert, B. A. Naber, E. E. Koster, E. F. de Haas, K. R. Atkuri, J. J. van Dongen, L. A. Herzenberg, and F. J. Staal. 2006. Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules. Proc. Natl. Acad. Sci. USA 103: 3322-3326.
17. Guo, Z., M. Dose, D. Kovalovsky, R. Chang, J. O'Neil, A. T. Look, H. von Boehmer, K. Khazaie, and F. Gounari. 2007. Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation. Blood 109: 5463-5472.
18. Tiemessen, M. M., M. R. Baert, T. Schonewille, M. H. Brugman, F. Famili, D. C. Salvatori, J. P. Meijerink, U. Ozbek, H. Clevers, J. J. van Dongen, and F. J. Staal. 2012. The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell-specific tumor suppressor for development of lymphomas. PLoS Biol. 10: e1001430.
19. Yu, S., X. Zhou, F. C. Steinke, C. Liu, S. C. Chen, O. Zagorodna, X. Jing, Y. Yokota, D. K. Meyerholz, C. G. Mullighan, et al. 2012. The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity 37: 813-826.
20. Staal, F. J., Mv. Noort Mv, G. J. Strous, and H. C. Clevers. 2002. Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin. EMBO Rep. 3: 63-68.
21. Jeannet, G., C. Boudousquié, N. Gardiol, J. Kang, J. Huelsken, and W. Held. 2010. Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory. Proc. Natl. Acad. Sci. USA 107: 9777-9782.
22. Zhou, X., S. Yu, D. M. Zhao, J. T. Harty, V. P. Badovinac, and H. H. Xue. 2010. Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1. Immunity 33: 229-240.
23. + memory stem cells. Nat. Med. 15: 808-813.
24. Lustig, B., B. Jerchow, M. Sachs, S. Weiler, T. Pietsch, U. Karsten, M. van de Wetering, H. Clevers, P. M. Schlag, W. Birchmeier, and J. Behrens. 2002. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol. Cell. Biol. 22: 1184-1193.
25. Northrop, J. K., R. M. Thomas, A. D. Wells, and H. Shen. 2006. Epigenetic remodeling of the IL-2 and IFN-γamma loci in memory CD8 T cells is influenced by CD4 T cells. J. Immunol. 177: 1062-1069.
26. Staal, F. J., F. Weerkamp, M. R. Baert, C. M. van den Burg, M. van Noort, E. F. de Haas, and J. J. van Dongen. 2004. Wnt target genes identified by DNA microarrays in immature CD34+ thymocytes regulate proliferation and cell adhesion. J. Immunol. 172: 1099-1108.
27. McCausland, M. M., and S. Crotty. 2008. Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo. J. Virol. Methods 147: 167-176.
28. Van de Wetering, M., J. Castrop, V. Korinek, and H. Clevers. 1996. Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. Mol. Cell. Biol. 16: 745-752.
29. Schilham, M. W., A. Wilson, P. Moerer, B. J. Benaissa-Trouw, A. Cumano, and H. C. Clevers. 1998. Critical involvement of Tcf-1 in expansion of thymocytes. J. Immunol. 161: 3984-3991.
30. Willinger, T., T. Freeman, M. Herbert, H. Hasegawa, A. J. McMichael, and M. F. Callan. 2006. Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. J. Immunol. 176: 1439-1446.
31. Luis, T. C., M. Ichii, M. H. Brugman, P. Kincade, and F. J. Staal. 2012. Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development. Leukemia 26: 414-421.
32. Gattinoni, L., E. Lugli, Y. Ji, Z. Pos, C. M. Paulos, M. F. Quigley, J. R. Almeida, E. Gostick, Z. Yu, C. Carpenito, et al. 2011. A human memory T cell subset with stem cell-like properties. Nat. Med. 17: 1290-1297.
33. Luis, T. C., B. A. Naber, P. P. Roozen, M. H. Brugman, E. F. de Haas, M. Ghazvini, W. E. Fibbe, J. J. van Dongen, R. Fodde, and F. J. Staal. 2011. Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion. Cell Stem Cell 9: 345-356.
34. Driessens, G., Y. Zheng, and T. F. Gajewski. 2010. Beta-catenin does not regulate memory T cell phenotype. Nat. Med. 16: 513-514, author reply 514-515.
35. Atcha, F. A., A. Syed, B. Wu, N. P. Hoverter, N. N. Yokoyama, J. H. Ting, J. E. Munguia, H. J. Mangalam, J. L. Marsh, and M. L. Waterman. 2007. A unique DNA binding domain converts T-cell factors into strong Wnt effectors. Mol. Cell. Biol. 27: 8352-8363.