Regulatory Forum Opinion Piece: New Testing Paradigms for Reproductive and Developmental Toxicity—The NTP Modified One Generation Study and OECD 443

Toxicologic Pathology

Volumn 42, Issue 8, 2014, Pages 1165-1167

  Foster, Paul M D ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

developmental pathology; endocrine disrupters; female reproduction; male reproduction; reproductive system; safety assessment

Indexed keywords

ARTICLE; DEVELOPMENTAL TOXICITY; IMMUNOTOXICITY; LACTATION; NEUROTOXICITY; NONHUMAN; PREGNANCY; REPRODUCTIVE TOXICITY; SEXUAL MATURITY; WEANING; ANIMAL; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HUMAN; MOUSE; ORGANISATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT; PROCEDURES; REPRODUCTION; STANDARDS; TOXICITY TESTING;

ENDOCRINE DISRUPTOR;

ANIMALS; ENDOCRINE DISRUPTORS; GROWTH AND DEVELOPMENT; HUMANS; MICE; ORGANISATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT; REPRODUCTION; TOXICITY TESTS;

EID: 84912529013     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623314534920     Document Type: Article

References (6)

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4. OECD (Organization for Economic Co-operation and Development). (2012). Test No. 443: Extended one-generation reproductive toxicity study, OECD guidelines for the testing of chemicals, Section 4: health effects. doi:10.1787/9789264185371-en
5. Thayer K. A. Foster P. M. (2007). Workgroup report: National Toxicology Program workshop on hormonally induced reproductive tumors—Relevance of rodent bioassays. Environ Health Perspect 115, 1351–56.
6. van der Jagt K. Munn S. Tørsløv J. de Bruijn J. (2004). Alternative Approaches can reduce the Use of Test Animals under Reach. Joint Research Centre, European Commission. Accessed February 21, 2014. http://publications.jrc.ec.europa.eu/repository/bitstream/111111111/8790/1/EUR%2021405%20EN.pdf.