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Volumn 115, Issue 9, 2007, Pages 1351-1356

Workgroup report: National toxicology program workshop on hormonally induced reproductive tumors - Relevance of Rodent bioassays

Author keywords

Animal models; Breast; Endocrine; Hormone; Mammary gland; National Toxicology Program; Ovary; Prostate; Reproductivetumors; Species differences; Testis

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ANDROGEN RECEPTOR; DIETHYLSTILBESTROL; DIMETHYLBENZ[A]ANTHRACENE; ETHYLBENZENE; FLUTAMIDE; INSULIN; ISOPRENE; K RAS PROTEIN; LUTEINIZING HORMONE; LUTEINIZING HORMONE RECEPTOR; ORAL CONTRACEPTIVE AGENT; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; POLYBROMINATED DIPHENYL ETHER; PROLACTIN; PROLACTIN RECEPTOR; PROTEIN KINASE B; PROTEIN P53; RETINOBLASTOMA PROTEIN; SOMATOMEDIN C;

EID: 34748888284     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.10135     Document Type: Conference Paper
Times cited : (27)

References (26)
  • 1
    • 0032466249 scopus 로고    scopus 로고
    • Very low sensitivity of Wistar:Han female rats to chemocarcinogens in mammary carcinogenesis induction
    • Ahlers I, Solar P, Buresova A, Ahlersova E. 1998. Very low sensitivity of Wistar:Han female rats to chemocarcinogens in mammary carcinogenesis induction. Neoplasma 45(6):373-376.
    • (1998) Neoplasma , vol.45 , Issue.6 , pp. 373-376
    • Ahlers, I.1    Solar, P.2    Buresova, A.3    Ahlersova, E.4
  • 2
    • 33745789903 scopus 로고    scopus 로고
    • NTP multigenerational study of environmental estrogens
    • Barrett JR. 2006. NTP multigenerational study of environmental estrogens. Environ Health Perspect 114:A348-349.
    • (2006) Environ Health Perspect , vol.114
    • Barrett, J.R.1
  • 3
    • 30044434186 scopus 로고    scopus 로고
    • A review of evidence from short-term studies leading to the prediction that diazoaminobenzene (1,3-diphenyltriazine) is a carcinogen
    • Bordelon NR, Chhabra R, Bucher JR. 2005. A review of evidence from short-term studies leading to the prediction that diazoaminobenzene (1,3-diphenyltriazine) is a carcinogen. J Appl Toxicol 25(6):514-521.
    • (2005) J Appl Toxicol , vol.25 , Issue.6 , pp. 514-521
    • Bordelon, N.R.1    Chhabra, R.2    Bucher, J.R.3
  • 4
    • 0027219805 scopus 로고
    • Comparative carcinogenicity of 5,5-diphenylhydantoin with or without perinatal exposure in rats and mice
    • Chhabra RS, Bucher JR, Haseman JK, Elwell MR, Kurtz PJ, Carlton BD. 1993a. Comparative carcinogenicity of 5,5-diphenylhydantoin with or without perinatal exposure in rats and mice. Fundam Appl Toxicol 21(2):174-186.
    • (1993) Fundam Appl Toxicol , vol.21 , Issue.2 , pp. 174-186
    • Chhabra, R.S.1    Bucher, J.R.2    Haseman, J.K.3    Elwell, M.R.4    Kurtz, P.J.5    Carlton, B.D.6
  • 5
    • 0027425097 scopus 로고
    • Comparative carcinogenicity of polybrominated biphenyls with or without perinatal exposure in rats and mice
    • Chhabra RS, Bucher JR, Haseman JK, Elwell MR, Kurtz PJ, Carlton BD. 1993b. Comparative carcinogenicity of polybrominated biphenyls with or without perinatal exposure in rats and mice. Fundam Appl Toxicol 21(4):451-460.
    • (1993) Fundam Appl Toxicol , vol.21 , Issue.4 , pp. 451-460
    • Chhabra, R.S.1    Bucher, J.R.2    Haseman, J.K.3    Elwell, M.R.4    Kurtz, P.J.5    Carlton, B.D.6
  • 6
    • 0032903895 scopus 로고    scopus 로고
    • Rodent Leydig cell tumorigenesis: A review of the physiology, pathology, mechanisms, and relevance to humans
    • Cook JC, Klinefelter GR, Hardisty JF, Sharpe RM, Foster PM. 1999. Rodent Leydig cell tumorigenesis: a review of the physiology, pathology, mechanisms, and relevance to humans. Crit Rev Toxicol 29(2):169-261.
    • (1999) Crit Rev Toxicol , vol.29 , Issue.2 , pp. 169-261
    • Cook, J.C.1    Klinefelter, G.R.2    Hardisty, J.F.3    Sharpe, R.M.4    Foster, P.M.5
  • 7
    • 0035679442 scopus 로고    scopus 로고
    • Compendium of chemical carcinogens by target organ: Results of chronic bioassays in rats, mice, hamsters, dogs, and monkeys
    • Gold LS, Manley NB, Slone TH, Ward JM. 2001. Compendium of chemical carcinogens by target organ: results of chronic bioassays in rats, mice, hamsters, dogs, and monkeys. Toxicol Pathol 29(6):639-652.
    • (2001) Toxicol Pathol , vol.29 , Issue.6 , pp. 639-652
    • Gold, L.S.1    Manley, N.B.2    Slone, T.H.3    Ward, J.M.4
  • 8
    • 0037370254 scopus 로고    scopus 로고
    • Leydig cell micronodules are a common finding in testicular biopsies from men with impaired spermatogenesis and are associated with decreased testosterone/LH ratio
    • Holm M, Rajpert-De Meyts E, Andersson AM, Skakkebaek NE. 2003. Leydig cell micronodules are a common finding in testicular biopsies from men with impaired spermatogenesis and are associated with decreased testosterone/LH ratio. J Pathol 199(3):378-386.
    • (2003) J Pathol , vol.199 , Issue.3 , pp. 378-386
    • Holm, M.1    Rajpert-De Meyts, E.2    Andersson, A.M.3    Skakkebaek, N.E.4
  • 9
    • 31644438171 scopus 로고    scopus 로고
    • A review of evidence leading to the prediction that 1,4-butanediol is not a carcinogen
    • Irwin RD. 2006. A review of evidence leading to the prediction that 1,4-butanediol is not a carcinogen. J Appl Toxicol 26(1):72-80.
    • (2006) J Appl Toxicol , vol.26 , Issue.1 , pp. 72-80
    • Irwin, R.D.1
  • 10
    • 34748815249 scopus 로고    scopus 로고
    • NTP Workshop: Animal Models for the NTP Rodent Cancer Bioassay: Stocks and Strains - Should We Switch?
    • King-Herbert A, Thayer K. 2006. NTP Workshop: Animal Models for the NTP Rodent Cancer Bioassay: Stocks and Strains - Should We Switch? Toxicol Pathol 34(6):802-805.
    • (2006) Toxicol Pathol , vol.34 , Issue.6 , pp. 802-805
    • King-Herbert, A.1    Thayer, K.2
  • 12
    • 34748890229 scopus 로고    scopus 로고
    • NTP. 2005b. Report on Carcinogens. Eleventh ed. Research Triangle Park, NC:National Toxicology Program. Available: http://ntp.niehs.nih.gov/go/ 19914 [accessed 2 February 2007].
    • NTP. 2005b. Report on Carcinogens. Eleventh ed. Research Triangle Park, NC:National Toxicology Program. Available: http://ntp.niehs.nih.gov/go/ 19914 [accessed 2 February 2007].
  • 13
    • 34748903837 scopus 로고    scopus 로고
    • NTP, 10 March, Available:, accessed 2 February, 2007
    • NTP. 2005c. Roadmap to Achieve the NTP Vision (10 March 2005). Available: http://ntp.niehs.nih.gov/go/vision [accessed 2 February 2007].
    • (2005) Roadmap to Achieve the NTP Vision
  • 14
    • 34748860057 scopus 로고    scopus 로고
    • NTP. 2006a. Draft NTP Technical Report on the Toxicology and Carcinogenesis Study of Genistein (CAS No. 446-72-0) in Sprague-Dawley Rats (Feed Study). Research Triangle Park, NC:National Toxicology Program. Available: http://ntp.niehs.nih.gov/go/28023 [accessed 2 February 2007].
    • NTP. 2006a. Draft NTP Technical Report on the Toxicology and Carcinogenesis Study of Genistein (CAS No. 446-72-0) in Sprague-Dawley Rats (Feed Study). Research Triangle Park, NC:National Toxicology Program. Available: http://ntp.niehs.nih.gov/go/28023 [accessed 2 February 2007].
  • 15
    • 33845989522 scopus 로고    scopus 로고
    • NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,2′,4,4′,5,5′-Hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
    • NTP National Toxicology Program, Technical Report 529. Research Triangle Park, NC:National Toxicology Program
    • NTP (National Toxicology Program). 2006b. NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,2′,4,4′,5,5′-Hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies). Technical Report 529. Research Triangle Park, NC:National Toxicology Program.
    • (2006)
  • 16
    • 34748912708 scopus 로고    scopus 로고
    • NTP (National Toxicology Program). 2006c. NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) (CAS No. 1746-01-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies). Technical Report 521. Research Triangle Park, NC:National Toxicology Program.
    • NTP (National Toxicology Program). 2006c. NTP Technical Report on the Toxicology and Carcinogenesis Studies of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) (CAS No. 1746-01-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies). Technical Report 521. Research Triangle Park, NC:National Toxicology Program.
  • 17
    • 34748919236 scopus 로고    scopus 로고
    • NTP, 20-21 September, Raleigh, NC. Research Triangle Park, NC:National Toxicology Program. Available:, accessed 2 February, 2007
    • NTP. 2006d. NTP Workshop: Biomarkers for Toxicology Studies, 20-21 September 2006, Raleigh, NC. Research Triangle Park, NC:National Toxicology Program. Available: http://ntp.niehs.nih.gov/go/20940 [accessed 2 February 2007].
    • (2006) NTP Workshop: Biomarkers for Toxicology Studies
  • 18
    • 34748836711 scopus 로고    scopus 로고
    • NTP, Research Triangle Park, NC. Research Triangle Park, NC:National Toxicology Program. Available:, accessed 2 February, 2007
    • NTP. 2006e. NTP Workshop: Hormonally Induced Reproductive Tumors - Relevance of Rodent Bioassays, 22-24 May 2006, Research Triangle Park, NC. Research Triangle Park, NC:National Toxicology Program. Available: http://ntp.niehs.nih.gov/go/18592 [accessed 2 February 2007].
    • (2006) NTP Workshop: Hormonally Induced Reproductive Tumors - Relevance of Rodent Bioassays, 22-24 May
  • 19
    • 34748833222 scopus 로고    scopus 로고
    • NTP. 2006f. Testing Status of 2,2′4,4′-Tetrabromodiphenyl Ether (DE-47). Research Triangle Park, NC:National Toxicology Program. Available: http://ntp.niehs.nih.gov/ see Testing Status of Agents at NTP [accessed 2 February 2007].
    • NTP. 2006f. Testing Status of 2,2′4,4′-Tetrabromodiphenyl Ether (DE-47). Research Triangle Park, NC:National Toxicology Program. Available: http://ntp.niehs.nih.gov/ see "Testing Status of Agents at NTP" [accessed 2 February 2007].
  • 20
    • 0031597895 scopus 로고    scopus 로고
    • Role of hormones in mammary cancer initiation and progression
    • Russo IH, Russo J. 1998. Role of hormones in mammary cancer initiation and progression. J Mammary Gland Biol Neoplasia 3(1):49-61.
    • (1998) J Mammary Gland Biol Neoplasia , vol.3 , Issue.1 , pp. 49-61
    • Russo, I.H.1    Russo, J.2
  • 21
    • 5744234424 scopus 로고    scopus 로고
    • Simanainen U, Adamsson A, Tuomisto JT, Miettinen HM, Toppari J, Tuomisto J, et al. 2004. Adult 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure and effects on male reproductive organs in three differentially TCDD-susceptible rat lines. Toxicol Sci 81(2):401-407.
    • Simanainen U, Adamsson A, Tuomisto JT, Miettinen HM, Toppari J, Tuomisto J, et al. 2004. Adult 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure and effects on male reproductive organs in three differentially TCDD-susceptible rat lines. Toxicol Sci 81(2):401-407.
  • 22
    • 18244379285 scopus 로고    scopus 로고
    • An investigation of the effects of late-onset dietary restriction on prostate cancer development in the TRAMP mouse
    • Suttie AW, Dinse GE, Nyska A, Moser GJ, Goldsworthy TL, Maronpot RR. 2005. An investigation of the effects of late-onset dietary restriction on prostate cancer development in the TRAMP mouse. Toxicol Pathol 33(3):386-397.
    • (2005) Toxicol Pathol , vol.33 , Issue.3 , pp. 386-397
    • Suttie, A.W.1    Dinse, G.E.2    Nyska, A.3    Moser, G.J.4    Goldsworthy, T.L.5    Maronpot, R.R.6
  • 23
    • 29344460270 scopus 로고    scopus 로고
    • Differential attenuation of oxidative/nitrosative injuries in early prostatic neoplastic lesions in TRAMP mice by dietary antioxidants
    • Tam NN, Nyska A, Maronpot RR, Kissling G, Lomnitski L, Suttie A, et al. 2006. Differential attenuation of oxidative/nitrosative injuries in early prostatic neoplastic lesions in TRAMP mice by dietary antioxidants. Prostate 66(1):57-69.
    • (2006) Prostate , vol.66 , Issue.1 , pp. 57-69
    • Tam, N.N.1    Nyska, A.2    Maronpot, R.R.3    Kissling, G.4    Lomnitski, L.5    Suttie, A.6
  • 24
    • 34748925582 scopus 로고    scopus 로고
    • U.S. EPA. 1998. Health Effects Test Guidelines. OPPTS 870.3800. Reproduction and Fertility Effects. Eleventh ed. Washington, DC:U.S. Environmental Protection Agency. Available: http://www.epa.gov/opptsfrs/ publications/OPPTS_Harmonized/870_Health_Effects_Test_Guidelines/Series/ 870-3800.pdf [accessed 2 February 2007].
    • U.S. EPA. 1998. Health Effects Test Guidelines. OPPTS 870.3800. Reproduction and Fertility Effects. Eleventh ed. Washington, DC:U.S. Environmental Protection Agency. Available: http://www.epa.gov/opptsfrs/ publications/OPPTS_Harmonized/870_Health_Effects_Test_Guidelines/Series/ 870-3800.pdf [accessed 2 February 2007].
  • 25
    • 34748873543 scopus 로고    scopus 로고
    • Washington, DC:U.S. Environmental Protection Agency. Available:, accessed 2 February
    • U.S. EPA. 2000. Atrazine: Evaluation of Carcinogenic Potential (memorandum). Washington, DC:U.S. Environmental Protection Agency. Available: http://www.epa.gov/opptsfrs/publications/OPPTS_Harmonized/ 870_Health_Effects_Test_Guidelines/Series/870-3800.pdf [accessed 2 February 2007].
    • (2000) Atrazine: Evaluation of Carcinogenic Potential (memorandum)
    • EPA, U.S.1
  • 26
    • 34748908183 scopus 로고    scopus 로고
    • Washington, DC:U.S. Environmental Protection Agency. Available:, accessed 24 January
    • U.S. EPA. 2006. Information on the Endocrine Disruptor Screening Program. Washington, DC:U.S. Environmental Protection Agency. Available: http://www.epa.gov/oppsrrd1/reregistration/REDs/atrazine_ired.pdf [accessed 24 January 2007].
    • (2006) Information on the Endocrine Disruptor Screening Program
    • EPA, U.S.1


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