TGFβ lengthens the G1 phase of stem cells in aged mouse brain

Stem Cells

Volumn 32, Issue 12, 2014, Pages 3257-3265

  Daynac, Mathieu ^a,b   Pineda, Jose R ^a,b   Chicheportiche, Alexandra ^a,b   Gauthier, Laurent R ^a,b   Morizur, Lise ^a,b   Boussin, François D ^a,b   Mouthon, Marc André ^a,b  

^a Universite Paris Sud   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Aging; Cell cycle; Flow cytometry; Neural stem cells; Neurogenesis; TGF beta

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; HOE 33342; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ANIMAL CELL; ARTICLE; BRAIN; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL DIVISION; CELL FRACTIONATION; CELL PROLIFERATION; CELL SELECTION; CONTROLLED STUDY; DNA CONTENT; IN VITRO STUDY; MIDDLE AGED; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NEUROBLAST; NONHUMAN; PROGENY; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENESCENCE; SIGNAL TRANSDUCTION; UBIQUITINATION; VIDEO MICROSCOPY; YOUNG ADULT; AGING; ANIMAL; C57BL MOUSE; CYTOLOGY; GENETICS; METABOLISM; PHYSIOLOGY; STEM CELL; STEM CELL NICHE;

AGING; ANIMALS; BRAIN; CELL DIFFERENTIATION; CELL PROLIFERATION; G1 PHASE; MICE, INBRED C57BL; NEUROGENESIS; STEM CELL NICHE; STEM CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 84912141326     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1815     Document Type: Article

References (34)

1. Doetsch F, Caille I, Lim DA, et al. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 1999; 97: 703-716.
2. Lepousez G, Valley MT, Lledo PM,. The impact of adult neurogenesis on olfactory bulb circuits and computations. Annu Rev Physiol 2013; 75: 339-363.
3. Lee SW, Clemenson GD, Gage FH,. New neurons in an aged brain. Behav Brain Res 2011; 227: 497-507.
4. Enwere E, Shingo T, Gregg C, et al. Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination. J Neurosci 2004; 24: 8354-8365.
5. Rey NL, Sacquet J, Veyrac A, et al. Behavioral and cellular markers of olfactory aging and their response to enrichment. Neurobiol Aging 2011; 33: 626.e629-626.e623.
6. Tropepe V, Craig CG, Morshead CM, et al. Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma. J Neurosci 1997; 17: 7850-7859.et al.
7. Blackmore DG, Golmohammadi MG, Large B, et al. Exercise increases neural stem cell number in a growth hormone-dependent manner, augmenting the regenerative response in aged mice. Stem Cells 2009; 27: 2044-2052.
8. Bouab M, Paliouras GN, Aumont A, et al. Aging of the subventricular zone neural stem cell niche: Evidence for quiescence-associated changes between early and mid-adulthood. Neuroscience 2011; 173: 135-149.
9. Ahlenius H, Visan V, Kokaia M, et al. Neural stem and progenitor cells retain their potential for proliferation and differentiation into functional neurons despite lower number in aged brain. J Neurosci 2009; 29: 4408-4419.
10. Maslov AY, Barone TA, Plunkett RJ, et al. Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice. J Neurosci 2004; 24: 1726-1733.
11. Lugert S, Basak O, Knuckles P, et al. Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. Cell Stem Cell 2010; 6: 445-456.
12. Shook BA, Manz DH, Peters JJ, et al. Spatiotemporal changes to the subventricular zone stem cell pool through aging. J Neurosci 2012; 32: 6947-6956.
13. Balordi F, Fishell G,. Mosaic removal of hedgehog signaling in the adult SVZ reveals that the residual wild-type stem cells have a limited capacity for self-renewal. J Neurosci 2007; 27: 14248-14259.
14. Sii-Felice K, Etienne O, Hoffschir F, et al. Fanconi DNA repair pathway is required for survival and long-term maintenance of neural progenitors. EMBO J 2008; 27: 770-781.
15. Doetsch F, Petreanu L, Caille I, et al. EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells. Neuron 2002; 36: 1021-1034.
16. Pineda JR, Daynac M, Chicheportiche A, et al. Vascular-derived TGF-beta increases in the stem cell niche and perturbs neurogenesis during aging and following irradiation in the adult mouse brain. EMBO Mol Med 2013; 5: 548-562.
17. Pastrana E, Cheng LC, Doetsch F,. Simultaneous prospective purification of adult subventricular zone neural stem cells and their progeny. Proc Natl Acad Sci USA 2009; 106: 6387-6392.
18. Daynac M, Chicheportiche A, Pineda JR, et al. Quiescent neural stem cells exit dormancy upon alteration of GABAAR signaling following radiation damage. Stem Cell Res 2013; 11: 516-528.
19. Sakaue-Sawano A, Kurokawa H, Morimura T, et al. Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell 2008; 132: 487-498.
20. Mouthon M-A, Fouchet P, Mathieu C, et al. Neural stem cells from mouse forebrain are contained in a population distinct from the 'side population'. J Neurochem 2006; 99: 807-817.
21. Molofsky AV, Slutsky SG, Joseph NM, et al. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 2006; 443: 448-452.
22. Kippin TE, Martens DJ, van der Kooy D,. p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity. Genes Dev 2005; 19: 756-767.
23. Costa MR, Ortega F, Brill MS, et al. Continuous live imaging of adult neural stem cell division and lineage progression in vitro. Development 2011; 138: 1057-1068.
24. Roccio M, Schmitter D, Knobloch M, et al. Predicting stem cell fate changes by differential cell cycle progression patterns. Development 2013; 140: 459-470.
25. Ponti G, Obernier K, Guinto C, et al. Cell cycle and lineage progression of neural progenitors in the ventricular-subventricular zones of adult mice. Proc Natl Acad Sci USA 2013; 110: E1045-1054.
26. Piccin D, Tufford A, Morshead CM,. Neural stem and progenitors in aged subependyma are activated by young niche. Neurobiol Aging 2014; 35: 1669-1679.
27. Blackmore DG, Vukovic J, Waters MJ, et al. GH mediates exercise-dependent activation of SVZ neural precursor cells in aged mice. PLoS One 2012; 7: e49912.
28. Jin K, Sun Y, Xie L, et al. Neurogenesis and aging: FGF-2 and HB-EGF restore neurogenesis in hippocampus and subventricular zone of aged mice. Aging Cell 2003; 2: 175-183.
29. Salomoni P, Calegari F,. Cell cycle control of mammalian neural stem cells: Putting a speed limit on G1. Trends Cell Biol 2010; 20: 233-243.
30. Zhang RL, Zhang ZG, Lu M, et al. Reduction of the cell cycle length by decreasing G1 phase and cell cycle reentry expand neuronal progenitor cells in the subventricular zone of adult rat after stroke. J Cereb Blood Flow Metab 2006; 26: 857-863.
31. Encinas JM, Michurina TV, Peunova N, et al. Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus. Cell Stem Cell 2011; 8: 566-579.
32. Yu SW, Baek SH, Brennan RT, et al. Autophagic death of adult hippocampal neural stem cells following insulin withdrawal. Stem Cells 2008; 26: 2602-2610.
33. Tavazoie M, Van der Veken L, Silva-Vargas V, et al. A specialized vascular niche for adult neural stem cells. Cell Stem Cell 2008; 3: 279-288.
34. Leonard BW, Mastroeni D, Grover A, et al. Subventricular zone neural progenitors from rapid brain autopsies of elderly subjects with and without neurodegenerative disease. J Comp Neurol 2009; 515: 269-294.