Oropharyngeal dysphagia in children: Mechanism, source, and management

Otolaryngologic Clinics of North America

Volumn 47, Issue 5, 2014, Pages 691-720

  Durvasula, Venkata S P B ^a   O'Neill, Ashley C ^a   Richter, Gresham T ^a  

^a ARKANSAS CHILDREN S HOSPITAL   (United States)

Author keywords

Aspiration; Children; Dysphagia; Microaspiration; Oropharyngeal dysphagia; Pediatric dysphagia; Pharyngeal; Swallowing disorders

Indexed keywords

LIPID;

AIRWAY OBSTRUCTION; ARTICLE; BREATHING; CHILDHOOD DISEASE; CLINICAL ASSESSMENT; CLINICAL EVALUATION; COMPUTER ASSISTED TOMOGRAPHY; COUGHING; DRINKING; DYSPHAGIA; ESOPHAGOSCOPY; FEEDING; FLUOROSCOPY; FOOD ASPIRATION; GASTROESOPHAGEAL REFLUX; HUMAN; INFLAMMATION; MACROPHAGE; NEUROLOGIC DISEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; OROPHARYNGEAL DYSPHAGIA; PHYSICAL EXAMINATION; PREMATURITY; SWALLOWING; THORAX RADIOGRAPHY; CHILD; CONGENITAL MALFORMATION; DEGLUTITION DISORDERS; DIGESTIVE TRACT ENDOSCOPY; DISEASE MANAGEMENT; EARLY DIAGNOSIS; FEMALE; MALE; PATHOPHYSIOLOGY; PHARYNX; PHYSIOLOGY; PRESCHOOL CHILD; PROCEDURES; PROGNOSIS; RESPIRATORY ASPIRATION; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

CHILD; CHILD, PRESCHOOL; DEGLUTITION; DEGLUTITION DISORDERS; DISEASE MANAGEMENT; EARLY DIAGNOSIS; ENDOSCOPY, DIGESTIVE SYSTEM; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PHARYNX; PROGNOSIS; RESPIRATORY ASPIRATION; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 84912138100     PISSN: 00306665     EISSN: 15578259     Source Type: Journal    
DOI: 10.1016/j.otc.2014.06.004     Document Type: Review

References (101)

1. Miller C.K., Willging J.P. Advances in the evaluation and management of pediatric dysphagia. Curr Opin Otolaryngol Head Neck Surg 2003, 11(6):442-446.
2. Lefton-Greif M.A., Arvedson J.C. Schoolchildren with dysphagia associated with medically complex conditions. Lang Speech Hear Serv Sch 2008, 39(2):237-248.
3. Martin J.A., Hamilton B.E., Ventura S.J., et al. Births: final data for 2009. Natl Vital Stat Rep 2011, 60(1):1-70.
4. Rommel N., De Meyer A.M., Feenstra L., et al. The complexity of feeding problems in 700 infants and young children presenting to a tertiary care institution. JPediatr Gastroenterol Nutr 2003, 37(1):75-84.
5. Seddon P.C., Khan Y. Respiratory problems in children with neurological impairment. Arch Dis Child 2003, 88(1):75-78.
6. Sheikh S., Allen E., Shell R., et al. Chronic aspiration without gastroesophageal reflux as a cause of chronic respiratory symptoms in neurologically normal infants. Chest 2001, 120(4):1190-1195.
7. Hewetson R., Singh S. The lived experience of mothers of children with chronic feeding and/or swallowing difficulties. Dysphagia 2009, 24(3):322-332.
8. Sleigh G. Mothers' voice: a qualitative study on feeding children with cerebral palsy. Child Care Health Dev 2005, 31(4):373-383.
9. Jadcherla S.R., Gupta A., Wang M., et al. Definition and implications of novel pharyngo-glottal reflex in human infants using concurrent manometry ultrasonography. Am J Gastroenterol 2009, 104(10):2572-2582.
10. Pereira N.A., Motta A.R., Vicente L.C. Swallowing reflex: analysis of the efficiency of different stimuli on healthy young individuals. Pro Fono 2008, 20(3):159-164.
11. Ulualp S., Brown A., Sanghavi R., et al. Assessment of laryngopharyngeal sensation in children with dysphagia. Laryngoscope 2013, 123(9):2291-2295.
12. Rempel G., Moussavi Z. The effect of viscosity on the breath-swallow pattern of young people with cerebral palsy. Dysphagia 2005, 20(2):108-112.
13. Timms B.J., DiFiore J.M., Martin R.J., et al. Increased respiratory drive as an inhibitor of oral feeding of preterm infants. JPediatr 1993, 123(1):127-131.
14. Kramer S.S. Special swallowing problems in children. Gastrointest Radiol 1985, 10(3):241-250.
15. Harding R. Perinatal development of laryngeal function. JDev Physiol 1984, 6(3):249-258.
16. Harding R. Function of the larynx in the fetus and newborn. Annu Rev Physiol 1984, 46:645-659.
17. Lau C., Smith E.O., Schanler R.J. Coordination of suck-swallow and swallow respiration in preterm infants. Acta Paediatr 2003, 92(6):721-727.
18. Conley S.F., Beecher R.B., Delaney A.L., et al. Outcomes of tonsillectomy in neurologically impaired children. Laryngoscope 2009, 119(11):2231-2241.
19. Sheppard J.J., Mysak E.D. Ontogeny of infantile oral reflexes and emerging chewing. Child Dev 1984, 55(3):831-843.
20. Stolovitz P., Gisel E.G. Circumoral movements in response to three different food textures in children 6 months to 2 years of age. Dysphagia 1991, 6(1):17-25.
21. Byars K.C., Burklow K.A., Ferguson K., et al. Amulticomponent behavioral program for oral aversion in children dependent on gastrostomy feedings. JPediatr Gastroenterol Nutr 2003, 37(4):473-480.
22. Durvasula V.S., Lawson B.R., Bower C.M., et al. Supraglottoplasty in premature infants with laryngomalacia: does gestation age at birth influence outcomes?. Otolaryngol Head Neck Surg 2014, 150(2):292-299.
23. Rommel N., van Wijk M., Boets B., et al. Development of pharyngo-esophageal physiology during swallowing in the preterm infant. Neurogastroenterol Motil 2011, 23(10):e401-e408.
24. Uhm K.E., Yi S.H., Chang H.J., et al. Videofluoroscopic swallowing study findings in full-term and preterm infants with Dysphagia. Ann Rehabil Med 2013, 37(2):175-182.
25. Derkay C.S., Schechter G.L. Anatomy and physiology of pediatric swallowing disorders. Otolaryngol Clin North Am 1998, 31(3):397-404.
26. Medoff-Cooper B., McGrath J.M., Bilker W. Nutritive sucking and neurobehavioral development in preterm infants from 34 weeks PCA to term. MCN Am J Matern Child Nurs 2000, 25:64-70.
27. Hack M., Estabrook M.M., Robertson S.S. Development of sucking rhythm in preterm infants. Early Hum Dev 1985, 11:133-140.
28. Medoff-Cooper B., McGrath J.M., Shults J. Feeding patterns of full-term and preterm infants at forty weeks postconceptional age. JDev Behav Pediatr 2002, 23:231-236.
29. Ancel P.Y., Livinec F., Larroque B., et al. Cerebral palsy among very preterm children in relation to gestational age and neonatal ultrasound abnormalities: the EPIPAGE cohort study. Pediatrics 2006, 117(3):828-835.
30. Rotschild A., Dison P.J., Chitayat D., et al. Mid-facial hypoplasia associated with long-term intubation for bronchopulmonary dysplasia. Am J Dis Child 1990, 144:1302-1306.
31. Rogers B., Arvedson J., Buck G., et al. Characteristics of dysphagia in children with cerebral palsy. Dysphagia 1994, 9(1):69-73.
32. Spiroglou K., Xinias I., Karatzas N., et al. Gastric emptying in children with cerebral palsy and gastroesophageal reflux. Pediatr Neurol 2004, 31(3):177-182.
33. Tahmassebi J.F., Curzon M.E. Prevalence of drooling in children with cerebral palsy attending special schools. Dev Med Child Neurol 2003, 45(9):613-617.
34. Tahmassebi J.F., Curzon M.E. The cause of drooling in children with cerebral palsy - hypersalivation or swallowing defect?. Dev Med Child Neurol 1993, 35(4):285-297.
35. Greenlee J.D., Donovan K.A., Hasan D.M., et al. Chiari I malformation in the very young child: the spectrum of presentations and experience in 31 children under age 6 years. Pediatrics 2002, 110(6):1212-1219.
36. Albert G.W., Menezes A.H., Hansen D.R., et al. Chiari malformation Type I in children younger than age 6 years: presentation and surgical outcome. J Neurosurg Pediatr 2010, 5(6):554-561.
37. O'Neill A.C., Richter G.T. Pharyngeal dysphagia in children with Down syndrome. Otolaryngol Head Neck Surg 2013, 149(1):146-150.
38. Smith M.E., Mortelliti A.J., Cotton R.T., et al. Phonation and swallowing considerations in pediatric laryngotracheal reconstruction. Ann Otol Rhinol Laryngol 1992, 101(9):731-738.
39. Thompson D.M. Abnormal sensorimotor integrative function of the larynx in congenital laryngomalacia: a new theory of etiology. Laryngoscope 2007, 117(6 Pt 2 Suppl 114):1-33.
40. Link D.T., Willging J.P., Miller C.K., et al. Pediatric laryngopharyngeal sensory testing during flexible endoscopic evaluation of swallowing: feasible and correlative. Head Neck Surg 2013, 149(1):146-150.
41. Munson P.D., Saad A.G., El-Jamal S.M., et al. Submucosal nerve hypertrophy in congenital laryngomalacia. Laryngoscope 2011, 121:627-629.
42. Goyal R.K., Martin S.B., Shapiro J., et al. The role of cricopharyngeus muscle in pharyngoesophageal disorders. Dysphagia 1993, 8(3):252-258.
43. Elidan J., Shochina M., Gonen B., et al. Electromyography of the inferior constrictor and cricopharyngeal muscles during swallowing. Ann Otol Rhinol Laryngol 1990, 99(6 Pt 1):466-469.
44. Chun R., Sitton M., Tipnis N.A., et al. Endoscopic cricopharyngeal myotomy for management of cricopharyngeal achalasia (CA) in an 18-month-old child. Laryngoscope 2013, 123(3):797-800.
45. Dinari G., Danziger Y., Mimouni M., et al. Cricopharyngeal dysfunction in childhood: treatment by dilatations. JPediatr Gastroenterol Nutr 1987, 6(2):212-216.
46. Dent J., El-Serag H.B., Wallander M.A., et al. Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut 2005, 54(5):710-717.
47. Martin A.J., Pratt N., Kennedy J.D., et al. Natural history and familial relationships of infant spilling to 9 years of age. Pediatrics 2002, 109(6):1061-1067.
48. Hassall E. Endoscopy in children with GERD: "the way we were" and the way we should be. Am J Gastroenterol 2002, 97(7):1583-1586.
49. Aviv J.E., Liu H., Parides M., et al. Laryngopharyngeal sensory deficits in patients with laryngopharyngeal reflux and dysphagia. Ann Otol Rhinol Laryngol 2000, 109(11):1000-1006.
50. Richter G.T. Management of oropharyngeal dysphagia in the neurologically intact and developmentally normal child. Curr Opin Otolaryngol Head Neck Surg 2010, 18(6):554-563.
51. Liacouras C.A., Furuta G.T., Hirano I., et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. JAllergy Clin Immunol 2011, 128(1):3-20.
52. Dellon E.S., Gonsalves N., Hirano I., American College of Gastroenterology, et al. ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE). Am J Gastroenterol 2013, 108(5):679-692.
53. Dauer E.H., Freese D.K., El-Youssef M., et al. Clinical characteristics of eosinophilic esophagitis in children. Ann Otol Rhinol Laryngol 2005, 114(11):827-833.
54. Dauer E.H., Ponikau J.U., Smyrk T.C., et al. Airway manifestations of pediatric eosinophilic esophagitis: a clinical and histopathologic report of an emerging association. Ann Otol Rhinol Laryngol 2006, 115(7):507-517.
55. Garcia-Careaga M., Kerner J.A. Gastrointestinal manifestations of food allergies in pediatric patients. Nutr Clin Pract 2005, 20(5):526-535.
56. Markowitz J.E., Spergel J.M., Ruchelli E., et al. Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents. Am J Gastroenterol 2003, 98(4):777-782.
57. Kagalwalla A.F., Sentongo T.A., Ritz S., et al. Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis. Clin Gastroenterol Hepatol 2006, 4(9):1097-1102.
58. Furuta G.T., Liacouras C.A., Collins M.H., First International Gastrointestinal Eosinophil Research Symposium (FIGERS) Subcommittees, et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology 2007, 133(4):1342-1363.
59. Warms T., Richards J. "Wet Voice" as a predictor of penetration and aspiration in oropharyngeal dysphagia. Dysphagia 2000, 15(2):84-88.
60. De Pippo K.L., Holas M.A., Reding M.J. Validation of the 3-ounce water swallow test for aspiration. Arch Neurol 1992, 49(12):1259-1261.
61. Suiter D.M., Leder S.B., Karas D.B. The 3-ounce (90-cc) water swallow challenge: a screening test for children with suspected oropharyngeal dysphagia. Otolaryngol Head Neck Surg 2009, 140(2):187-190.
62. Boesch R.P., Daines C., Wilging J.P., et al. Advances in the diagnosis and management of chronic pulmonary aspiration in children. Eur Respir J 2006, 28(4):847-861.
63. de Benedictis F.M., Carnielli V.P., de Benedictis D. Aspiration lung disease. Pediatr Clin North Am 2009, 56(1):173-190.
64. Steinbok P. Clinical features of Chiari I malformations. Childs Nerv Syst 2004, 20(5):329-331.
65. Colombo J.L., Hallberg T.K. Recurrent aspiration in children: lipid-laden alveolar macrophage quantitation. Pediatr Pulmonol 1987, 3(2):86-89.
66. Furuya M.E., Moreno-Cordova V., Ramirez-Figueroa J.L., et al. Cutoff value of lipid-laden alveolar macrophages for diagnosing aspiration in infants and children. Pediatr Pulmonol 2007, 42(5):452-457.
67. Kieran S.M., Katz E., Rosen R., et al. The lipid laden macrophage index as a marker of aspiration in patients with type I and II laryngeal clefts. Int J Pediatr Otorhinolaryngol 2010, 74(7):743-746.
68. Knauer-Fischer S., Ratjen F. Lipid-laden macrophages in bronchoalveolar lavage fluid as a marker for pulmonary aspiration. Pediatr Pulmonol 1999, 27(6):419-422.
69. Stoeckli S.J., Huisman T.A., Seifert B., et al. Interrater reliability of videofluoroscopic swallow evaluation. Dysphagia 2003, 18(1):53-57.
70. Logemann J.A. The role of the speech language pathologist in the management of dysphagia. Otolaryngol Clin North Am 1988, 21(4):783-788.
71. Arvedson J.C. Assessment of pediatric dysphagia and feeding disorders: clinical and instrumental approaches. Dev Disabil Res Rev 2008, 14(2):118-127.
72. Miller C.K., Willging J.P. The implications of upper airway obstruction on successful infant feeding. Semin Speech Lang 2007, 28(3):190-203.
73. Friedman B., Frazier J.B. Deep laryngeal penetration as a predictor of aspiration. Dysphagia 2000, 15:153-158.
74. Newman L.A., Keckley C., Petersen M.C., et al. Swallowing function and medical diagnoses in infants suspected of dysphagia. Pediatrics 2001, 108:E106.
75. Weir K.A., McMahon S., Taylor S., et al. Oropharyngeal aspiration and silent aspiration in children. Chest 2011, 140:589-597.
76. Langmore S.E., Schatz K., Olsen N. Fiberoptic endoscopic examination of swallowing safety: a new procedure. Dysphagia 1988, 2:216-219.
77. Willging J.P. Endoscopic evaluation of swallowing in children. Int J Pediatr Otorhinolaryngol 1995, 32(Suppl):S107-S108.
78. Hartnick C., Hartley B.E., Miller C., et al. Pediatric fiberoptic endoscopic evaluation of swallowing. Ann Otol Rhinol Laryngol 2000, 109:996-999.
79. Leder S.B., Karas D.E. Fiberoptic endoscopic evaluation of swallowing in the pediatric population. Laryngoscope 2000, 110:1132-1136.
80. American Speech-Language-Hearing Association. Role of the speech-language pathologist in the performance and interpretation of endoscopic evaluation of swallowing. ASHA Position Statement. 2005. Available at: . http://www.ASHA.org.
81. Miller C.K., Willging J.P., Strife J.L., et al. Fiberoptic endoscopic examination of swallowing in infants and children with feeding disorders. Dysphagia 1994, 9:266.
82. Lefton-Greif M.A., Carroll J.L., Loughlin G.M. Long-term follow-up of oropharyngeal dysphagia in children without apparent risk factors. Pediatr Pulmonol 2006, 41(11):1040-1048.
83. Giambra B.K., Meinzen-Derr J. Exploration of the relationships among medical health history variables and aspiration. Int J Pediatr Otorhinolaryngol 2010, 74(4):387-392.
84. Rudolph C.D., Mazur L.J., Liptak G.S., North American Society for Pediatric Gastroenterology and Nutrition, et al. Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: recommendations of the North American Society for Pediatric Gastroenterology and Nutrition. JPediatr Gastroenterol Nutr 2001, 32(Suppl 2):S1-S31.
85. Litalien C., Theoret Y., Faure C. Pharmacokinetics of proton pump inhibitors in children. Clin Pharmacokinet 2005, 44(5):441-466.
86. Gibbons T.E., Gold B.D. The use of proton pump inhibitors in children: a comprehensive review. Paediatr Drugs 2003, 5(1):25-40.
87. van der Pol R.J., Smits M.J., van Wijk M.P., et al. Efficacy of proton-pump inhibitors in children with gastroesophageal reflux disease: a systematic review. Pediatrics 2011, 127(5):925-935.
88. Orenstein S.R., Hassall E., Furmaga-Jablonska W., et al. Multicenter, double-blind, randomized, placebo-controlled trial assessing the efficacy and safety of proton pump inhibitor lansoprazole in infants with symptoms of gastroesophageal reflux disease. JPediatr 2009, 154(4):514-520.e4.
89. Miller C.K. Aspiration and swallowing dysfunction in pediatric patients. Infant Child Adolesc Nutr 2011, 3:336-343.
90. Gosa M.S., Schooling T., Coleman J. Thickened liquids as a treatment for children with dysphagia and associated adverse effects: a systematic review. Infant Child Adolesc Nutr 2011, 3:344-350.
91. McCallum S. Addressing nutrient density in the context of the use of thickened liquids in dysphagia treatment. Infant Child Adolesc Nutr 2011, 3:351-360.
92. Cichero J.A., Nicholson T.M., September C. Thickened milk for the management of feeding and swallowing issues in infants: a call for interdisciplinary professional guidelines. JHum Lact 2013, 29(2):132-135.
93. Almeida M.B., Almeida J.A., Moreira M.E., et al. Adequacy of human milk viscosity to respond to infants with dysphagia: experimental study. JAppl Oral Sci 2011, 19(6):554-559.
94. Montero M., Bower C.M., Richter G.T. Oropharyngeal dysphagia in neurologically normal children 2011, American Society of Pediatric Otolaryngology, Chicago.
95. Friedman AB, O'Neill AC, Bower CM, et al. Impact of tonsillectomy on aspiration in neurologically normal children. Presented at Society of Ear Nose and Throat Advancement in Children Meeting. Kansas City, December 4-5, 2011.
96. Allen J.E., White C.J., Leonard R.J., et al. Prevalence of penetration and aspiration on videofluoroscopy in normal individuals without dysphagia. Otolaryngol Head Neck Surg 2010, 142(2):208-213.
97. Richter G.T., Wootten C.T., Rutter M.J., et al. Impact of supraglottoplasty on aspiration in severe laryngomalacia. Ann Otol Rhinol Laryngol 2009, 118:259-266.
98. Bakthavachalam S., Schroeder J.W., Holinger L.D. Diagnosis and management of type I posterior laryngeal clefts. Ann Otol Rhinol Laryngol 2010, 119(4):239-248.
99. Cohen M.S., Zhuang L., Simons J.P., et al. Injection laryngoplasty for type 1 laryngeal cleft in children. Otolaryngol Head Neck Surg 2011, 144(5):789-793.
100. Mangat H.S., El-Hakim H. Injection augmentation of type I laryngeal clefts. Otolaryngol Head Neck Surg 2012, 146(5):764-768.
101. Weir K., McMahon S., Barry L., et al. Oropharyngeal aspiration and pneumonia in children. Pediatr Pulmonol 2007, 42(11):1024-1031.