Enhancing the solubility and bioavailability of isoflavone by particle size reduction using a supercritical carbon dioxide-based precipitation process

Chemical Engineering Research and Design

Volumn 92, Issue 11, 2014, Pages 2542-2549

  Xu, Jinjie ^a   Luo, Kathy Qian ^b  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b Nanyang Technological University   (Singapore)

Author keywords

Bioavailability; Isoflavone; Particle size; Precipitation process; Solubility; Supercritical carbon dioxide

Indexed keywords

ACETONE; BIOCHEMISTRY; CARBON DIOXIDE; FLAVONOIDS; PARTICLE SIZE; PRECIPITATION (CHEMICAL); SOLUBILITY;

BIOAVAILABILITY; ISOFLAVONES; OPTIMIZED CONDITIONS; ORAL BIOAVAILABILITIES; PARTICLE SIZE REDUCTION; PLASMA CONCENTRATION; PRECIPITATION PROCESS; SUPERCRITICAL CARBON DIOXIDES;

SUPERCRITICAL FLUID EXTRACTION;

EID: 84912120119     PISSN: 02638762     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cherd.2014.03.018     Document Type: Article

References (17)

1. Altavilla D., Crisafulli A., Marini H., Esposito M., D'Anna R., Corrado F., Bitto A., Squadrito F. Cardiovascular effects of the phytoestrogen genistein. Curr. Med. Chem. Cardiovasc. Hematol. Agents 2004, 2:179-186.
2. Daruhazi A.E., Szente L., Balogh B., Matyus P., Beni S., Takacs M., Gergely A., Horvath P., Szoke E., Lemberkovics E. Utility of cyclodextrins in the formulation of genistein part 1. Preparation and physicochemical properties of genistein complexes with native cyclodextrins. J. Pharm. Biomed. Anal. 2008, 48:636-640.
3. Dixon D.J., Johnston K.P., Bodmeier R.A. Polymeric materials formed by precipitation with a compressed fluid antisolvent. AICHE J. 1993, 39:127-139.
4. Kim M.S., Lee S., Park J.S., Woo J.S., Hwang S.J. Micronization of cilostazol using supercritical antisolvent (SAS) process: effect of process parameters. Powder Technol. 2007, 177:64-70.
5. Lee S.H., Kim Y.H., Yu H.J., Cho N.S., Kim T.H., Kim D.C., Chung C.B., Hwang Y.I., Kim K.H. Enhanced bioavailability of soy isoflavones by complexation with beta-cyclodextrin in rats. Biosci. Biotechnol. Biochem. 2007, 71:2927-2933.
6. Li Z., Li J., Mo B., Hu C., Liu H., Qi H., Wang X., Xu J. Genistein induces G2/M cell cycle arrest via stable activation of ERK1/2 pathway in MDA-MB-231 breast cancer cells. Cell Biol. Toxicol. 2008, 24:401-409.
7. Lin C., Ng K.M., Wibowo C. Producing nanoparticles using precipitation with compressed antisolvent. Ind. Eng. Chem. Res. 2007, 46:3580-3589.
8. Lipinski C. Poor aqueous solubility - an industry wide problem in drug discovery. Am. Pharm. Rev. 2002, 5:82-85.
9. Motlekar N., Khan M.A., Youan B.B.C. Preparation and characterization of genistein containing poly(ethylene glycol) microparticles. J. Appl. Polym. Sci. 2006, 101:2070-2078.
10. Noyes A.A. The rate of solution of solid substances in their own solutions. J. Am. Chem. Soc. 1897, 10:930-934.
11. Reverchon E., De Marco I., Della Porta G. Tailoring of nano- and micro-particles of some superconductor precursors by supercritical antisolvent precipitation. J. Supercrit. Fluids 2002, 23:81-87.
12. Sarkar F.H., Li Y. Mechanisms of cancer chemoprevention by soy isoflavone genistein. Cancer Metastasis Rev. 2002, 21:265-280.
13. Stancanelli R., Mazzaglia A., Tommasini S., Calabro M.L., Villari V., Guardo M., Ficarra P., Ficarra R. The enhancement of isoflavones water solubility by complexation with modified cyclodextrins: a spectroscopic investigation with implications in the pharmaceutical analysis. J. Pharm. Biomed. Anal. 2007, 44:980-984.
14. Suthar A.C., Banavalikar M.M., Biyani M.K. Pharmacological activities of genistein, an isoflavone from soy (glycine max): part I - anti-cancer activity. Indian J. Exp. Biol. 2001, 39:511-519.
15. Suthar A.C., Banavalikar M.M., Biyani M.K. Pharmacological activities of Genistein, an isoflavone from soy (Glycine max): part II - anti-cholesterol activity, effects on osteoporosis & menopausal symptoms. Indian J. Exp. Biol. 2001, 39:520-525.
16. Wu K., Li J. Precipitation of a biodegradable polymer using compressed carbon dioxide as antisolvent. J. Supercrit. Fluids 2008, 46:211-216.
17. Zhang E.J., Ng K.M., Luo K.Q. Extraction and purification of isoflavones from soybeans and characterization of their estrogenic activities. J. Agric. Food Chem. 2007, 55:6940-6950.