The human synaptic vesicle protein, SV2A, functions as a galactose transporter in Saccharomyces cerevisiae

Journal of Biological Chemistry

Volumn 289, Issue 48, 2014, Pages 33066-33071

  Madeo, Marianna ^a   Kovács, Attila D ^a   Pearce, David A ^a,b  

^a SANFORD RESEARCH   (United States)

^b UNIVERSITY OF SOUTH DAKOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; CYTOLOGY; PROTEINS;

ANTIEPILEPTIC DRUGS; DIRECT MEASUREMENT; MAJOR FACILITATOR SUPERFAMILY; NEUROTRANSMITTER RELEASE; SECOND GENERATION; SEQUENCE ANALYSIS; TRANSPORT CAPABILITIES; TRANSPORT PROTEINS;

YEAST;

CARRIER PROTEIN; ETIRACETAM; GALACTOSE; GALACTOSE TRANSPORTER; MEMBRANE PROTEIN; SYNAPTIC VESICLE PROTEIN; UNCLASSIFIED DRUG; ANTICONVULSIVE AGENT; GLUCOSE TRANSPORTER; NERVE PROTEIN; PIRACETAM; RECOMBINANT PROTEIN; SV2A PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CARBOHYDRATE TRANSPORT; CELL GROWTH; CONTROLLED STUDY; CULTURE MEDIUM; HEXOSE TRANSPORT; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; SACCHAROMYCES CEREVISIAE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SYNAPTIC TRANSMISSION; YEAST CELL; ACTIVE TRANSPORT; ANALOGS AND DERIVATIVES; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; SYNAPSE;

SACCHAROMYCES CEREVISIAE;

ANTICONVULSANTS; BIOLOGICAL TRANSPORT, ACTIVE; GALACTOSE; HUMANS; MEMBRANE GLYCOPROTEINS; MONOSACCHARIDE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PIRACETAM; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; SYNAPSES;

EID: 84912097816     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C114.584516     Document Type: Article

References (27)

1. Bajjalieh, S. M., Peterson, K., Shinghal, R., and Scheller, R. H. (1992) SV2, a brain synaptic vesicle protein homologous to bacterial transporters. Science 257, 1271-1273
2. Kwon, S. E., and Chapman, E. R. (2012) Glycosylation is dispensable for sorting of synaptotagmin 1 but is critical for targeting of SV2 and synaptophysin to recycling synaptic vesicles. J. Biol. Chem. 287, 35658-35668
3. Crèvecoeur, J., Kaminski, R. M., Rogister, B., Foerch, P., Vandenplas, C., Neveux, M., Mazzuferi, M., Kroonen, J., Poulet, C., Martin, D., Sadzot, B., Rikir, E., Klitgaard, H., Moonen, G., and Deprez, M. (2014) Expression pattern of synaptic vesicle protein 2 (SV2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis. Neuropathol. Appl. Neurobiol. 40, 191-204
4. Yao, J., Nowack, A., Kensel-Hammes, P., Gardner, R. G., and Bajjalieh, S. M. (2010) Cotrafficking of SV2 and synaptotagmin at the synapse. J. Neurosci. 30, 5569-5578
5. 2+ and synaptotagmin: insights from a large CNS synapse. Trends Neurosci. 34, 237-246
6. 2+-induced exocytosis. J. Neurosci. 29, 883-897
7. Lynch, B. A., Lambeng, N., Nocka, K., Kensel-Hammes, P., Bajjalieh, S. M., Matagne, A., and Fuks, B. (2004) The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc. Natl. Acad. Sci. U.S.A. 101, 9861-9866
8. Yang, X. F., Weisenfeld, A., and Rothman, S. M. (2007) Prolonged exposure to levetiracetam reveals a presynaptic effect on neurotransmission. Epilepsia 48, 1861-1869
9. Meehan, A. L., Yang, X., McAdams, B. D., Yuan, L., and Rothman, S. M. (2011) A new mechanism for antiepileptic drug action: vesicular entry may mediate the effects of levetiracetam. J. Neurophysiol. 106, 1227-1239
10. Feany, M. B., Lee, S., Edwards, R. H., and Buckley, K. M. (1992) The synaptic vesicle protein SV2 is a novel type of transmembrane transporter. Cell 70, 861-867
11. Palacios, G., Casas, I., Tenorio, A., and Freire, C. (2002) Molecular identification of enterovirus by analyzing a partial VP1 genomic region with different methods. J. Clin. Microbiol. 40, 182-192
12. Wieczorke, R., Krampe, S., Weierstall, T., Freidel, K., Hollenberg, C. P., and Boles, E. (1999) Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae. FEBS Lett. 464, 123-128
13. Chattopadhyay, S., and Pearce, D. A. (2002) Interaction with Btn2p is required for localization of Rsglp: Btn2p-mediated changes in arginine uptake in Saccharomyces cerevisiae. Eukaryot. Cell 1, 606-612
14. Torre, E. R., and Steward, O. (1996) Protein synthesis within dendrites: glycosylation of newly synthesized proteins in dendrites of hippocampal neurons in culture. J. Neurosci. 16, 5967-5978
15. Pohle, W., Acosta, L., Rüthrich, H., Krug, M., and Matthies, H. (1987) Incorporation of [3H]fucose in rat hippocampal structures after conditioning by perforant path stimulation and after LTP-producing tetanization. Brain Res. 410, 245-256
16. Matthies, H., Staak, S., and Krug, M. (1996) Fucose and fucosyllactose enhance in-vitro hippocampal long-term potentiation. Brain Res. 725, 276-280
17. Krug, M., Wagner, M., Staak, S., and Smalla, K. H. (1994) Fucose and fucose-containing sugar epitopes enhance hippocampal long-term potentiation in the freely moving rat. Brain Res. 643, 130-135
18. Tiunova, A. A., Anokhin, K. V., and Rose, S. P. (1998) Two critical periods of protein and glycoprotein synthesis in memory consolidation for visual categorization learning in chicks. Learn. Mem. 4, 401-410
19. Rose, S. P., and Jork, R. (1987) Long-term memory formation in chicks is blocked by 2-deoxygalactose, a fucose analog. Behav. Neural Biol. 48, 246-258
20. Lorenzini, C. G., Baldi, E., Bucherelli, C., Sacchetti, B., and Tassoni, G. (1997) 2-Deoxy-D-galactose effects on passive avoidance memorization in the rat. Neurobiol. Learn. Mem. 68, 317-324
21. Krug, M., Jork, R., Reymann, K., Wagner, M., and Matthies, H. (1991) The amnesic substance 2-deoxy-D-galactose suppresses the maintenance of hippocampal LTP. Brain Res. 540, 237-242
22. Murrey, H. E., Gama, C. I., Kalovidouris, S. A., Luo, W. I., Driggers, E. M., Porton, B., and Hsieh-Wilson, L. C. (2006) Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons. Proc. Natl. Acad. Sci. U.S.A. 103, 21-26
23. Brewer, G. J., Torricelli, J. R., Evege, E. K., and Price, P. J. (1993) Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J. Neurosci. Res. 35, 567-576
24. Badawy, R. A., Harvey, A. S., and Macdonell, R. A. (2009) Cortical hyperexcitability and epileptogenesis: understanding the mechanisms of epilepsy - Part 1. J. Clin. Neurosci. 16, 355-365
25. Bordji, K., Becerril-Ortega, J., and Buisson, A. (2011) Synapses, NMDA receptor activity and neuronal Aβ production in Alzheimer's disease. Rev. Neurosci. 22, 285-294
26. Bowie, D. (2008) Ionotropic glutamate receptors & CNS disorders. CNS Neurol. Disord. Drug Targets. 7, 129-143
27. Sanchez, P. E., Zhu, L., Verret, L., Vossel, K. A., Orr, A. G., Cirrito, J. R., Devidze, N., Ho, K., Yu, G. Q., Palop, J. J., and Mucke, L. (2012) Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. Proc. Natl. Acad. Sci. U.S.A. 109, E2895-E2903