Phenylalanine iminoboronates as new phenylalanine hydroxylase modulators

RSC Advances

Volumn 4, Issue 105, 2014, Pages 61022-61027

  Montalbano, Francesco ^a   Leandro, João ^a   Farias, Gonҫalo D V F ^a   Lino, Paulo R ^a   Guedes, Rita C ^a   Vicente, João B ^a   Leandro, Paula ^a   Gois, Pedro M P ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; MODULATORS;

ALLOSTERIC ACTIVATOR; ARYL BORONIC ACIDS; BINDING AFFINITIES; DIASTEREOSELECTIVITIES; L-PHENYLALANINE; PHENYL BORONIC ACIDS; PHENYLALANINE HYDROXYLASE; SALICYLALDEHYDE;

AMINO ACIDS;

EID: 84912049493     PISSN: None     EISSN: 20462069     Source Type: Journal    
DOI: 10.1039/c4ra10306h     Document Type: Article

References (26)

1. M. I. Flydal and A. Martinez, IUBMB Life, 2013, 65, 341-349.
2. J. J. Mitchell, Y. J. Trakadis and C. R. Scriver, Genet. Med., 2011, 13, 697-707.
3. L. Adler-Abramovich, L. Vaks, O. Carny, D. Trudler, A. Magno, A. Caflisch, D. Frenkel and E. Gazit, Nat. Chem. Biol., 2012, 8, 701-706.
4. V. Singh, R. K. Rai, A. Arora, N. Sinha and A. K. Thakur, Sci. Rep., 2014, 4, 3875.
5. J. Underhaug, O. Aubi and A. Martinez, Curr. Top. Med. Chem., 2012, 12, 2534-2545.
6. F. J. van Spronsen and G. M. Enns, Mol. Genet. Metab., 2010, 99(suppl. 1), S90-S95.
7. A. Martinez, A. C. Calvo, K. Teigen and A. L. Pey, Prog. Mol. Biol. Transl. Sci., 2008, 83, 89-134.
8. R. Torreblanca, E. Lira-Navarrete, J. Sancho and R. Hurtado-Guerrero, ChemBioChem, 2012, 13, 1266-1269.
9. A. L. Pey, M. Ying, N. Cremades, A. Velazquez-Campoy, T. Scherer, B. Thony, J. Sancho and A. Martinez, J. Clin. Invest., 2008, 118, 2858-2867.
10. T. Flatmark and R. C. Stevens, Chem. Rev., 1999, 99, 2137-2160.
11. J. P. Abita, S. Milstien, N. Chang and S. Kaufman, J. Biol. Chem., 1976, 251, 5310-5314.
12. J. Leandro, P. Leandro and T. Flatmark, Biochim. Biophys. Acta, 2011, 1812, 602-612.
13. T. Solstad and T. Flatmark, Eur. J. Biochem., 2000, 267, 6302-6310.
14. J. Tipper and S. Kaufman, J. Biol. Chem., 1992, 267, 889-896.
15. J. Li, U. Ilangovan, S. C. Daubner, A. P. Hinck and P. F. Fitzpatrick, Arch. Biochem. Biophys., 2011, 505, 250-255.
16. M. Thórólfsson, B. Ibarra-Molero, P. Fojan, S. B. Petersen, J. M. Sanchez-Ruiz and A. Martinez, Biochemistry, 2002, 41, 7573-7585.
17. S. Santos-Sierra, J. Kirchmair, A. M. Perna, D. Reiss, K. Kemter, W. Roschinger, H. Glossmann, S. W. Gersting, A. C. Muntau, G. Wolber and F. B. Lagler, Hum. Mol. Genet., 2012, 21, 1877-1887.
18. F. Montalbano, P. M. Cal, M. A. Carvalho, L. M. Goncalves, S. D. Lucas, R. C. Guedes, L. F. Veiros, R. Moreira and P. M. Gois, Org. Biomol. Chem., 2013, 11, 4465-4472.
19. F. Montalbano, N. R. Candeias, L. F. Veiros, V. Andre, M. T. Duarte, M. R. Bronze, R. Moreira and P. M. Gois, Org. Lett., 2012, 14, 988-991.
20. O. A. Andersen, A. J. Stokka, T. Flatmark and E. Hough, J. Mol. Biol., 2003, 333, 747-757.
21. O. A. Andersen, T. Flatmark and E. Hough, J. Mol. Biol., 2002, 320, 1095-1108.
22. P. Leandro, I. Rivera, M. C. Lechner, I. T. de Almeida and D. Konecki, Mol. Genet. Metab., 2000, 69, 204-212.
23. R. Kand'ar and P. Zakova, J. Chromatogr. B: Anal. Technol. Biomed. Life Sci., 2009, 877, 3926-3929.
24. G. Jones, P. Willett, R. C. Glen, A. R. Leach and R. Taylor, J. Mol. Biol., 1997, 267, 727-748.
25. Molecular Operating Environment (MOE), 2013.2010, Chemical Computing Group Inc, Montreal Canada, 2012, http://www.chemcomp.com.
26. W. L. Delano, The PyMOL Molecular Graphics System, DeLano Scientific, San Carlos, USA., 2002.