Attention enhancing effects of methylphenidate are age-dependent

Experimental Gerontology

Volumn 61, Issue , 2015, Pages 1-7

  Bhattacharya, Shevon E ^a   Shumsky, Jed S ^a   Waterhouse, Barry D ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Aging; Attention; Methylphenidate; Monoamine; Psychostimulant; Rat

Indexed keywords

METHYLPHENIDATE;

ADULT; AGED; ANIMAL EXPERIMENT; ARTICLE; ATTENTION; COGNITION; CONTROLLED STUDY; DRUG EFFECT; LOCOMOTION; MALE; MOTOR PERFORMANCE; NONHUMAN; RAT; SPRAGUE DAWLEY RAT; TASK PERFORMANCE; AGE; ANIMAL; DRUG EFFECTS; MOTOR ACTIVITY;

RATTUS;

AGE FACTORS; ANIMALS; ATTENTION; MALE; METHYLPHENIDATE; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84912022761     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2014.11.006     Document Type: Article

References (42)

1. Agster K.L., Clark B.D., Gao W.J., Shumsky J.S., Wang H.X., Berridge C.W., Waterhouse B.D. Experimental strategies for investigating psychostimulant drug actions and prefrontal cortical function in ADHD and related attention disorders. Anat. Rec. (Hoboken) 2011, 294:1698-1712.
2. Ahluwalia N., Gordon M.A., Handte G., Mahlon M., Li N.Q., Beard J.L., Weinstock D., Ross A.C. Iron status and stores decline with age in Lewis rats. J. Nutr. 2000, 130:2378-2383.
3. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 2000, (Washington, D.C.).
4. Arnsten A.F., Dudley A.G. Methylphenidate improves prefrontal cortical cognitive function through alpha2 adrenoceptor and dopamine D1 receptor actions: relevance to therapeutic effects in attention deficit hyperactivity disorder. Behav. Brain Funct. 2005, 1:2.
5. Arnsten A.F., Cai J.X., Murphy B.L., Goldman-Rakic P.S. Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys. Psychopharmacology (Berl.) 1994, 116:143-151.
6. Barense M.D., Fox M.T., Baxter M.G. Aged rats are impaired on an attentional set-shifting task sensitive to medial frontal cortex damage in young rats. Learn. Mem. 2002, 9:191-201.
7. Berridge C.W., Devilbiss D.M. Psychostimulants as cognitive enhancers: the prefrontal cortex, catecholamines, and attention-deficit/hyperactivity disorder. Biol. Psychiatry 2011, 69:e101-e111.
8. Berridge C.W., Shumsky J.S., Andrzejewski M.E., McGaughy J.A., Spencer R.C., Devilbiss D.M., Waterhouse B.D. Differential sensitivity to psychostimulants across prefrontal cognitive tasks: differential involvement of noradrenergic alpha(1)- and alpha(2)-receptors. Biol. Psychiatry 2012, 71:467-473.
9. Bickford P. Motor learning deficits in aged rats are correlated with loss of cerebellar noradrenergic function. Brain Res. 1993, 620:133-138.
10. Bickford P., Heron C., Young D.A., Gerhardt G.A., De La Garza R. Impaired acquisition of novel locomotor tasks in aged and norepinephrine-depleted F344 rats. Neurobiol. Aging 1992, 13:475-481.
11. Cain R.E., Wasserman M.C., Waterhouse B.D., McGaughy J.A. Atomoxetine facilitates attentional set shifting in adolescent rats. Dev. Cogn. Neurosci. 2011, 1:552-559.
12. Carlson M.C., Xue Q.L., Zhou J., Fried L.P. Executive decline and dysfunction precedes declines in memory: the Women's Health and Aging Study II. J. Gerontol. A Biol. Sci. Med. Sci. 2009, 64:110-117.
13. Devilbiss D.M., Berridge C.W. Cognition-enhancing doses of methylphenidate preferentially increase prefrontal cortex neuronal responsiveness. Biol. Psychiatry 2008, 64:626-635.
14. Ding Y.-S., Gatley S.J., Thanos P.K., Shea C., Garza V., Xu Y., Carter P., King P., Warner D., Taintor N.B., Park D.J., Pyatt B., Fowler J.S., Volkow N.D. Brain kinetics of methylphenidate (Ritalin) enantiomers after oral administration. Synapse 2004, 53:168-175.
15. Donfrancesco R., Parisi P., Vanacore N., Martines F., Sargentini V., Cortese S. Iron and ADHD: time to move beyond serum ferritin levels. J. Atten. Disord. 2013, 17:347-357.
16. Galynker I., Ieronimo C., Miner C., Rosenblum J., Vilkas N., Rosenthal R. Methylphenidate treatment of negative symptoms in patients with dementia. J. Neuropsychiatry Clin. Neurosci. 1997, 9:231-239.
17. Glock D., Gauron E.F., Rowley V.N. Effects of methylphenidate on avoidance learning in the aged rat. J. Gen. Psychol. 1977, 96:263-266.
18. Greenwood P.M., Parasuraman R., Alexander G.E. Controlling the focus of spatial attention during visual search: effects of advanced aging and Alzheimer's disease. Neuropsychology 1997, 11:3-12.
19. Grudzien A., Shaw P., Weintraub S., Bigio E., Mash D.C., Mesulam M.M. Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease. Neurobiol. Aging 2007, 28:327-335.
20. Hanlon J.T., Schmader K.E., Ruby C.M., Weinberger M. Suboptimal prescribing in older inpatients and outpatients. J. Am. Geriatr. Soc. 2001, 49:200-209.
21. Hannestad J., Gallezot J.D., Planeta-Wilson B., Lin S.F., Williams W.A., van Dyck C.H., Malison R.T., Carson R.E., Ding Y.S. Clinically relevant doses of methylphenidate significantly occupy norepinephrine transporters in humans in vivo. Biol. Psychiatry 2010, 68:854-860.
22. Hardy S.E. Methylphenidate for the treatment of depressive symptoms, including fatigue and apathy, in medically ill older adults and terminally ill adults. Am. J. Geriatr. Pharmacother. 2009, 7:34-59.
23. Ishida Y., Shirokawa T., Komatsu Y., Isobe K. Changes in cortical noradrenergic axon terminals of locus coeruleus neurons in aged F344 rats. Neurosci. Lett. 2001, 307:197-199.
24. Ishida Y., Shirokawa T., Miyaishi O., Komatsu Y., Isobe K. Age-dependent changes in noradrenergic innervations of the frontal cortex in F344 rats. Neurobiol. Aging 2001, 22:283-286.
25. Kerr C.W., Drake J., Milch R.A., Brazeau D.A., Skretny J.A., Brazeau G.A., Donnelly J.P. Effects of methylphenidate on fatigue and depression: a randomized, double-blind, placebo-controlled trial. J. Pain Symptom Manag. 2012, 43:68-77.
26. Konofal E., Lecendreux M., Deron J., Marchand M., Cortese S., Zaim M., Mouren M.C., Arnulf I. Effects of iron supplementation on attention deficit hyperactivity disorder in children. Pediatr. Neurol. 2008, 38:20-26.
27. LaSarge C., Nicolle M. Comparison of different cognitive rat models of human aging. Animal Models of Human Cognitive Aging 2009, Humana Press, New York. J.L. Bizon, A. Woods (Eds.).
28. Manor I., Rozen S., Zemishlani Z., Weizman A., Zalsman G. When does it end? Attention-deficit/hyperactivity disorder in the middle aged and older populations. Clin. Neuropharmacol. 2011, 34:148-154.
29. Matsunaga W., Shirokawa T., Isobe K. BDNF is necessary for maintenance of noradrenergic innervations in the aged rat brain. Neurobiol. Aging 2004, 25:341-348.
30. McCabe S.E., Knight J.R., Teter C.J., Wechsler H. Non-medical use of prescription stimulants among US college students: prevalence and correlates from a national survey. Addiction 2005, 100:96-106.
31. McGaughy J., Eichenbaum H. It's time to pay attention to attention in aging. Learn. Mem. 2002, 9:151-152.
32. McGaughy J., Sarter M. Behavioral vigilance in rats: task validation and effects of age, amphetamine, and benzodiazepine receptor ligands. Psychopharmacology (Berl.) 1995, 117:340-357.
33. Muir J.L., Fischer W., Bjorklund A. Decline in visual attention and spatial memory in aged rats. Neurobiol. Aging 1999, 20:605-615.
34. Padala P.R., Burke W.J., Shostrom V.K., Bhatia S.C., Wengel S.P., Potter J.F., Petty F. Methylphenidate for apathy and functional status in dementia of the Alzheimer type. Am. J. Geriatr. Psychiatry 2010, 18:371-374.
35. Parasuraman R., Giambra L. Skill development in vigilance: effects of event rate and age. Psychol. Aging 1991, 6:155-169.
36. Patkar A.A., Masand P.S., Pae C.U., Peindl K., Hooper-Wood C., Mannelli P., Ciccone P. A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depression. J. Clin. Psychopharmacol. 2006, 26:653-656.
37. Riddle E.L., Fleckenstein A.E., Hanson G.R. Role of monoamine transporters in mediating psychostimulant effects. AAPS J. 2005, 7:E847-E851.
38. Robbins T.W., James M., Owen A.M., Sahakian B.J., McInnes L., Rabbitt P. Cambridge Neuropsychological Test Automated Battery (CANTAB): a factor analytic study of a large sample of normal elderly volunteers. Dementia 1994, 5:266-281.
39. Salive M.E., Cornoni-Huntley J., Guralnik J.M., Phillips C.L., Wallace R.B., Ostfeld A.M., Cohen H.J. Anemia and hemoglobin levels in older persons: relationship with age, gender, and health status. J. Am. Geriatr. Soc. 1992, 40:489-496.
40. Suresh K.P., Chandrashekara S. Sample size estimation and power analysis for clinical research. J. Hum. Reprod. Sci. 2012, 5:7-13.
41. U.S.Census Bureau Statistical Abstract of the United States 2012, (Washington, D.C.).
42. Wargin W., Patrick K., Kilts C., Gualtieri C.T., Ellington K., Mueller R.A., Kraemer G., Breese G.R. Pharmacokinetics of methylphenidate in man, rat and monkey. J. Pharmacol. Exp. Ther. 1983, 226:382-386.