High content analysis of an in vitro model for metabolic toxicity: Results with the model toxicants 4-aminophenol and Cyclophosphamide

Journal of Biomolecular Screening

Volumn 19, Issue 10, 2014, Pages 1402-1408

  Cole, Stephanie D ^a   Madren Whalley, Janna S ^b   Li, Albert P ^c   Dorsey, Russell ^b   Salem, Harry ^b,d  

^a NATIONAL RESEARCH COUNCIL   (United States)

^b EDGEWOOD CHEMICAL BIOLOGICAL CENTER   (United States)

^c In Vitro ADMET Laboratories Inc ^*  (United States)

^d Chemical Security Analysis Center   (United States)

Author keywords

3T3 L1 cells; co culture; high content analysis; human hepatocytes; in vitro toxicology; metabolism

Indexed keywords

4 AMINOPHENOL; CYCLOPHOSPHAMIDE; ETHIDIUM; HOMODIMER; 4-AMINOPHENOL; AMINOPHENOL DERIVATIVE;

3T3 CELL LINE; ARTICLE; CALCEIN-AM ASSAY; CONTENT ANALYSIS; CONTROLLED STUDY; DETOXIFICATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; LIVER TOXICITY; METABOLIC ACTIVATION; ANIMAL; COCULTURE; DRUG EFFECTS; DRUG INACTIVATION; FLUORESCENCE; IMAGE PROCESSING; METABOLISM; MOUSE; PROCEDURES; TOXICITY TESTING;

3T3-L1 CELLS; AMINOPHENOLS; ANIMALS; COCULTURE TECHNIQUES; CYCLOPHOSPHAMIDE; FLUORESCENCE; HEPATOCYTES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INACTIVATION, METABOLIC; MICE; TOXICITY TESTS;

EID: 84912010039     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057114550399     Document Type: Article

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