Metabolism of para-aminophenol by rat hepatocytes

Drug Metabolism and Disposition

Volumn 28, Issue 8, 2000, Pages 880-886

  Yan, Z ^a   Nikelly, J G ^a   Killmer L , Jr ^a   Tarloff, J B ^a  

^a UNIVERSITY OF THE SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPHENOL; AMINOPHENOL DERIVATIVE; DRUG METABOLITE; PARACETAMOL;

ANIMAL EXPERIMENT; ARTICLE; CELL VIABILITY; DRUG CONJUGATION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER TOXICITY; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCYSTEINE; AMINOPHENOLS; ANIMALS; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTATHIONE; KIDNEY; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 0033853614     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. A simple and sensitive assay of 7-ethoxycoumarin deethylation
2. The nephrotoxicity of p-aminophenol. II. The effect of metabolic inhibitors and inducers
3. Early functional and morphological changes in renal tubular necrosis due to p-aminophenol
4. The metabolism of aminophenols in erythrocytes
5. Activation and detoxication of aminophenols. II. Synthesis and structure elucidation of various thiol addition products of 1,4- benzoquinoneimine and N-acetyl-1,4-benzoquinoneimine
6. Genotoxicity of p-aminophenol in somatic and germ line cells of Drosophila melanogaster
7. Kinetics of the formation and secretion of the aniline metabolite 4- aminophenol and its conjugates by isolated rat hepatocytes
8. The synthesis of two phenacetin metabolites
9. Nephrotoxicity of 4-amino-3-S-glutathionylphenol and its modulation by metabolism or transport inhibitors
10. Nephrotoxicity of 4-aminophenol glutathione conjugate
11. Effects of biliary cannulation and buthionine sulphoximine pretreatment on the nephrotoxicity of para-aminophenol in Fischer 344 rat
12. P-Aminophenol induced DNA damage and cytotoxicity enhanced by autoxidation
13. Paracetamol metabolism following overdose: Application of high performance liquid chromatography
14. Oxidation of p-arninophenol catalyzed by horseradish peroxidase and prostaglandin synthase
15. Drug metabolism in hepatocyte sandwich cultures of rats and humans
16. P-Aminophenol nephrotoxicity: Biosynthesis of toxic glutathione conjugates
17. The oxidative metabolism of hydralazine by rat liver microsomes
18. Hypoxia and oxygen dependence of cytotoxicity in renal proximal tubular and distal tubular cells
19. Studies on the mechanism of 4-aminophenolinduced toxicity to renal proximal tubules
20. Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse
21. Isolation and use of the liver cell
22. The contribution of oxidation and deacetylation to acetaminophen nephrotoxicity in female Sprague-Dawley rats
23. Nephrotoxicity of p-aminophenol, a metabolite of acetaminophen, in the Fischer 344 rat
24. Acetaminophen nephrotoxicity in the rat: Quantitation of renal metabolic activation in vivo
25. Fate of hydralazine in man. I. Reactions under gastric conditions
26. Metabolism of the nephrotoxicant N-(3,5-dichlorophenyl-)succinimide by isolated rat hepatocytes
27. Apparent rates of glutathione turnover in rat tissues
28. Coincubation of rat renal proximal tubules with hepatic subcellular fractions potentiates the effects of para-aminophenol
29. Lack of correlation between para-aminophenol toxicity in vivo and in vitro in female Sprague-Dawley rats
30. Benzazepine metabolism revised, evidence for the formation of novel amine conjugates
31. Acetaminophen and p-aminophenol nephrotoxicity in aging male Sprague- Dawley and Fischer 344 rats
32. Human liver sulphotransferase and UDP-glucuronosyltransferase: Structure-activity relationship for phenolic substrates
33. Characterization of a carbamic acid ester glucuronide of a secondary anime sertraline
34. Identification of urinary metabolites in rats treated with p- chloronitrobenzene
35. Identification of urinary metabolites of human subjects acutely poisoned by p-chloronitrobenzene