Downregulation of cytochrome P450scc as an initial adverse effect of adult exposure to diethylstilbestrol on testicular steroidogenesis

Environmental Toxicology

Volumn 29, Issue 12, 2014, Pages 1452-1459

  Maeda, Naoyuki ^a,b   Okumura, Kanako ^a   Tanaka, Emi ^b   Suzuki, Tomokazu ^b   Miyasho, Taku ^a   Haeno, Satoko ^a   Ueda, Hiromi ^a   Hoshi, Nobuhiko ^c   Yokota, Hiroshi ^a  

^a RAKUNO GAKUEN UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c KOBE UNIVERSITY   (Japan)

Author keywords

Cytochrome P450scc; Diethylstilbestrol; Endocrine disruptor; Initial adverse effect; Testicular steroidogenesis

Indexed keywords

BIOCHEMISTRY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MITOCHONDRIA; PROTEINS; RATS; STARS; TOXICITY;

ADVERSE EFFECT; CYTOCHROME P450SCC; DIETHYLSTILBESTROL; ENDOCRINE DISRUPTOR; TESTICULAR STEROIDOGENESIS;

CHOLESTEROL;

BENZODIAZEPINE RECEPTOR; CHOLESTEROL; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); DIETHYLSTILBESTROL; PREGNENOLONE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE; ENDOCRINE DISRUPTOR; ESTROGEN; MESSENGER RNA; PHOSPHOPROTEIN;

ADULT; ADVERSE OUTCOME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; EXPOSURE; HORMONE SYNTHESIS; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; REPRODUCTIVE TOXICITY; SEX HORMONE DETERMINATION; STEROIDOGENESIS; TESTIS TISSUE; ANIMAL; BLOOD; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; RAT; SPRAGUE DAWLEY RAT; TESTIS;

ANIMALS; CHOLESTEROL; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; DIETHYLSTILBESTROL; DOWN-REGULATION; ENDOCRINE DISRUPTORS; ESTROGENS, NON-STEROIDAL; HUMANS; MALE; MITOCHONDRIA; PHOSPHOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TESTIS; TESTOSTERONE;

EID: 84911951166     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.21875     Document Type: Article

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