ARFGAP1 is dynamically associated with lipid droplets in hepatocytes

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Gannon, Joan ^a   Fernandez Rodriguez, Julia ^b   Alamri, Hussam ^a   Feng, Shi Bo ^a   Kalantari, Fariba ^a   Negi, Sarita ^a   Wong, Amy H Y ^a   Mazur, Alexander ^a   Asp, Lennart ^b   Fazel, Ali ^a   Salman, Ayat ^a   Lazaris, Anthoula ^a   Metrakos, Peter ^a   Bergeron, John J M ^a   Nilsson, Tommy ^a  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARF GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; CYCLIC AMP; FAT DROPLET; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; OLEIC ACID; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN; ARFGAP1 PROTEIN, HUMAN; BIOLOGICAL MARKER; PLIN3 PROTEIN, HUMAN; VESICULAR TRANSPORT PROTEIN;

ARTICLE; CELL COUNT; CELL CULTURE; CELL SIZE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GOLGI COMPLEX; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER; LIVER CELL; MOLECULAR DYNAMICS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; STEADY STATE; DRUG EFFECTS; GENE SILENCING; METABOLISM; PROTEIN TRANSPORT; TUMOR CELL LINE; ULTRASTRUCTURE;

BIOMARKERS; CELL LINE, TUMOR; CYCLIC AMP; ENDOPLASMIC RETICULUM; GENE KNOCKDOWN TECHNIQUES; GOLGI APPARATUS; GTPASE-ACTIVATING PROTEINS; HEPATOCYTES; HUMANS; LIPID DROPLETS; LIVER; OLEIC ACID; PROTEIN TRANSPORT; VESICULAR TRANSPORT PROTEINS;

EID: 84911934836     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0111309     Document Type: Article

References (47)

1. Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, et al. (2008) Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature 453: 657-661
2. Beller M, Sztalryd C, Southall N, Bell M, Jackle H, et al. (2008) COPI complex is a regulator of lipid homeostasis. PLoS Biol 6: e292
3. Soni KG, Mardones GA, Sougrat R, Smirnova E, Jackson CL, et al. (2009) Coatomer-dependent protein delivery to lipid droplets. J Cell Sci 122: 1834-1841
4. Thiam AR, Antonny B, Wang J, Delacotte J, Wilfling F, et al. (2013) COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp function. Proc Natl Acad Sci U S A 110: 13244-13249
5. Wilfling F, Thiam AR, Olarte MJ, Wang J, Beck R, et al. (2014) Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting. Elife 3: e01607
6. Kahn RA (2009) Toward a model for Arf GTPases as regulators of traffic at the Golgi. FEBS Lett 583: 3872-3879
7. Kahn RA, Randazzo P, Serafini T, Weiss O, Rulka C, et al. (1992) The amino terminus of ADP-ribosylation factor (ARF) is a critical determinant of ARF activities and is a potent and specific inhibitor of protein transport. J Biol Chem 267: 13039-13046
8. Balch WE, Kahn RA, Schwaninger R (1992) ADP-ribosylation factor is required for vesicular trafficking between the endoplasmic reticulum and the cis-Golgi compartment. J Biol Chem 267: 13053-13061
9. Donaldson JG, Kahn RA, Lippincott-Schwartz J, Klausner RD (1991) Binding of ARF and beta-COP to Golgi membranes: possible regulation by a trimeric G protein. Science 254: 1197-1199
10. Lanoix J, Ouwendijk J, Lin CC, Stark A, Love HD, et al. (1999) GTP hydrolysis by arf-1 mediates sorting and concentration of Golgi resident enzymes into functional COP I vesicles. EMBO J 18: 4935-4948
11. Malsam J, Gommel D, Wieland FT, Nickel W (1999) A role for ADP ribosylation factor in the control of cargo uptake during COPI-coated vesicle biogenesis. FEBS Lett 462: 267-272
12. Pepperkok R, Whitney JA, Gomez M, Kreis TE (2000) COPI vesicles accumulating in the presence of a GTP restricted arf1 mutant are depleted of anterograde and retrograde cargo. J Cell Sci 113 (Pt 1): 135-144
13. Cockcroft S, Thomas GM, Fensome A, Geny B, Cunningham E, et al. (1994) Phospholipase D: a downstream effector of ARF in granulocytes. Science 263: 523-526
14. Brown HA, Gutowski S, Moomaw CR, Slaughter C, Sternweis PC (1993) ADPribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity. Cell 75: 1137-1144
15. Godi A, Pertile P, Meyers R, Marra P, Di Tullio G, et al. (1999) ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex. Nat Cell Biol 1: 280-287
16. Boman AL, Zhang C, Zhu X, Kahn RA (2000) A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi. Mol Biol Cell 11: 1241-1255
17. Dell'Angelica EC, Puertollano R, Mullins C, Aguilar RC, Vargas JD, et al. (2000) GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex. J Cell Biol 149: 81-94
18. Nakamura N, Akashi T, Taneda T, Kogo H, Kikuchi A, et al. (2004) ADRP is dissociated from lipid droplets by ARF1-dependent mechanism. Biochem Biophys Res Commun 322: 957-965
19. Nakamura N, Banno Y, Tamiya-Koizumi K (2005) Arf1-dependent PLD1 is localized to oleic acid-induced lipid droplets in NIH3T3 cells. Biochem Biophys Res Commun 335: 117-123
20. Asp L, Kartberg F, Fernandez-Rodriguez J, Smedh M, Elsner M, et al. (2009) Early stages of Golgi vesicle and tubule formation require diacylglycerol. Mol Biol Cell 20: 780-790
21. Fernandez-Ulibarri I, Vilella M, Lazaro-Dieguez F, Sarri E, Martinez SE, et al. (2007) Diacylglycerol is required for the formation of COPI vesicles in the Golgito-ER transport pathway. Mol Biol Cell 18: 3250-3263
22. Antonny B, Huber I, Paris S, Chabre M, Cassel D (1997) Activation of ADPribosylation factor 1 GTPase-Activating protein by phosphatidylcholine-derived diacylglycerols. J Biol Chem 272: 30848-30851
23. Bigay J, Gounon P, Robineau S, Antonny B (2003) Lipid packing sensed by ArfGAP1 couples COPI coat disassembly to membrane bilayer curvature. Nature 426: 563-566
24. Cukierman E, Huber I, Rotman M, Cassel D (1995) The ARF1 GTPaseactivating protein: zinc finger motif and Golgi complex localization. Science 270: 1999-2002
25. Lee SY, Yang JS, Hong W, Premont RT, Hsu VW (2005) ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation. J Cell Biol 168: 281-290
26. Bai M, Gad H, Turacchio G, Cocucci E, Yang JS, et al. (2011) ARFGAP1 promotes AP-2-dependent endocytosis. Nat Cell Biol 13: 559-567
27. Stafa K, Trancikova A, Webber PJ, Glauser L, West AB, et al. (2012) GTPase activity and neuronal toxicity of Parkinson's disease-Associated LRRK2 is regulated by ArfGAP1. PLoS Genet 8: e1002526
28. Xiong Y, Yuan C, Chen R, Dawson TM, Dawson VL (2012) ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2. J Neurosci 32: 3877-3886
29. Aoe T, Cukierman E, Lee A, Cassel D, Peters PJ, et al. (1997) The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase-Activating protein for ARF1. EMBO J 16: 7305-7316
30. Lanoix J, Ouwendijk J, Stark A, Szafer E, Cassel D, et al. (2001) Sorting of Golgi resident proteins into different subpopulations of COPI vesicles: a role for ArfGAP1. J Cell Biol 155: 1199-1212
31. Ou WJ, Cameron PH, Thomas DY, Bergeron JJ (1993) Association of folding intermediates of glycoproteins with calnexin during protein maturation. Nature 364: 771-776
32. Diaz E, Pfeffer SR (1998) TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking. Cell 93: 433-443
33. Duden R, Griffiths G, Frank R, Argos P, Kreis TE (1991) Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-Adaptin. Cell 64: 649-665
34. Fullekrug J, Suganuma T, Tang BL, Hong W, Storrie B, et al. (1999) Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members. Mol Biol Cell 10: 1939-1955
35. Jungas RL (1966) Role of cyclic-3',5'-Amp in the response of adipose tissue to insulin. Proc Natl Acad Sci U S A 56: 757-763
36. Bartz R, Zehmer JK, Zhu M, Chen Y, Serrero G, et al. (2007) Dynamic activity of lipid droplets: protein phosphorylation and GTP-mediated protein translocation. J Proteome Res 6: 3256-3265
37. Takashima K, Saitoh A, Hirose S, Nakai W, Kondo Y, et al. (2011) GBF1-Arf-COPI-ArfGAP-mediated Golgi-to-ER transport involved in regulation of lipid homeostasis. Cell Struct Funct 36: 223-235
38. Gubern A, Barcelo-Torns M, Casas J, Barneda D, Masgrau R, et al. (2009) Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on group VIA phospholipase A2. J Biol Chem 284: 5697-5708
39. Bostrom P, Andersson L, Rutberg M, Perman J, Lidberg U, et al. (2007) SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity. Nat Cell Biol 9: 1286-1293
40. Chen JL, Xu W, Stamnes M (2005) In vitro reconstitution of ARF-regulated cytoskeletal dynamics on Golgi membranes. Methods Enzymol 404: 345-358
41. Wada I, Rindress D, Cameron PH, Ou WJ, Doherty JJ , et al. (1991) SSR alpha and associated calnexin are major calcium binding proteins of the endoplasmic reticulum membrane. J Biol Chem 266: 19599-19610
42. Gocze PM, Vahrson HW, Freeman DA (1994) Serum levels of squamous cell carcinoma antigen and ovarian carcinoma antigen (CA 125) in patients with benign and malignant diseases of the uterine cervix. Oncology 51: 430-434
43. Frigerio G, Grimsey N, Dale M, Majoul I, Duden R (2007) Two human ARFGAPs associated with COP-I-coated vesicles. Traffic 8: 1644-1655
44. Simionescu N, Simionescu M (1976) Galloylglucoses of low molecular weight as mordant in electron microscopy. I. Procedure, and evidence for mordanting effect. J Cell Biol 70: 608-621
45. Tokuyasu KT (1973) A technique for ultracryotomy of cell suspensions and tissues. J Cell Biol 57: 551-565
46. Liou W, Geuze HJ, Slot JW (1996) Improving structural integrity of cryosections for immunogold labeling. Histochem Cell Biol 106: 41-58
47. Liu W, Duden R, Phair RD, Lippincott-Schwartz J (2005) ArfGAP1 dynamics and its role in COPI coat assembly on Golgi membranes of living cells. J Cell Biol 168: 1053-1063.