ENPP2 contributes to adipose tissue expansion and insulin resistance in diet-induced obesity

Diabetes

Volumn 63, Issue 12, 2014, Pages 4154-4164

  Nishimura, Satoshi ^a,b   Nagasaki, Mika ^a   Okudaira, Shinichi ^c   Aoki, Junken ^c   Ohmori, Tsukasa ^b   Ohkawa, Ryunosuke ^d   Nakamura, Kazuhiro ^d   Igarashi, Koji ^e   Yamashita, Hiroshi ^a   Eto, Koji ^f   Uno, Kansei ^a   Hayashi, Naoto ^a   Kadowaki, Takashi ^a   Komuro, Issei ^a   Yatomi, Yutaka ^d   Nagai, Ryozo ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^e TOSOH CORPORATION   (Japan)

^f KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOTAXIN; ALKYLGLYCEROPHOSPHOETHANOLAMINE PHOSPHODIESTERASE; PHOSPHODIESTERASE;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL HYPERPLASIA; CONTROLLED STUDY; DIET; DIET INDUCED OBESITY; DOWN REGULATION; ENERGY EXPENDITURE; ENZYME RELEASE; FEMALE; FOOD INTAKE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HAPLOINSUFFICIENCY; HUMAN; HUMAN TISSUE; INBORN ERROR OF METABOLISM; INSULIN RESISTANCE; INSULIN TOLERANCE TEST; KNOCKOUT MOUSE; LIPID OXIDATION; LIPID STORAGE; MALE; MOUSE; MULTIPHOTON MICROSCOPY; NONHUMAN; OBESITY; PROTEIN EXPRESSION; SUBCUTANEOUS FAT; T LYMPHOCYTE ACTIVATION; TISSUE EXPANSION; TISSUE METABOLISM; WEIGHT GAIN; WHITE ADIPOSE TISSUE; ANIMAL; CELL PROLIFERATION; ENERGY METABOLISM; GENETICS; INTRAABDOMINAL FAT; LIPID DIET; METABOLISM; PHYSIOLOGY;

ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; CELL PROLIFERATION; DIET, HIGH-FAT; DOWN-REGULATION; ENERGY METABOLISM; HUMANS; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; MICE; MICE, KNOCKOUT; OBESITY; PHOSPHORIC DIESTER HYDROLASES; SUBCUTANEOUS FAT;

EID: 84911876711     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-1694     Document Type: Article

References (27)

1. Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 2006;116:1784-1792
2. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444:860-867
3. Yuelling LM, Fuss B. Autotaxin (ATX): a multi-functional and multi-modular protein possessing enzymatic lysoPLD activity and matricellular properties. Biochim Biophys Acta 2008;1781:525-530
4. van Meeteren LA, Moolenaar WH. Regulation and biological activities of the autotaxin-LPA axis. Prog Lipid Res 2007;46:145-160
5. van Meeteren LA, Ruurs P, Stortelers C, et al. Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development. Mol Cell Biol 2006;26:5015-5022
6. Dusaulcy R, Rancoule C, Grès S, et al. Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid. J Lipid Res 2011;52:1247-1255
7. Federico L, Ren H, Mueller PA, et al. Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice. Mol Endocrinol 2012;26:786-797
8. Tanaka M, Okudaira S, Kishi Y, et al. Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. J Biol Chem 2006;281:25822-25830
9. Liu D, Wen J, Liu J, Li L. The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids. FASEB J 1999;13:2318-2328
10. Nishimura S, Manabe I, Nagasaki M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 2009;15:914-920
11. Brake DK, Smith EO, Mersmann H, Smith CW, Robker RL. ICAM-1 expression in adipose tissue: effects of diet-induced obesity in mice. Am J Physiol Cell Physiol 2006;291:C1232-C1239
12. Nishimura S, Manabe I, Nagasaki M, et al. In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. J Clin Invest 2008;118:710-721
13. Camp HS, Chaudhry A, Leff T. A novel potent antagonist of peroxisome proliferator-activated receptor gamma blocks adipocyte differentiation but does not revert the phenotype of terminally differentiated adipocytes. Endocrinology 2001;142:3207-3213
14. Nishimura S, Manabe I, Nagasaki M, et al. Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes 2007;56:1517-1526
15. Nakamura K, Igarashi K, Ide K, et al. Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation. Clin Chim Acta 2008;388:51-58
16. van der Meer IM, Bots ML, Hofman A, del Sol AI, van der Kuip DA, Witteman JC. Predictive value of noninvasive measures of atherosclerosis for incident myocardial infarction: the Rotterdam Study. Circulation 2004;109:1089-1094
17. Boucher J, Quilliot D, Pradères JP, et al. Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D/autotaxin expression. Diabetologia 2005;48:569-577
18. Lee KY, Russell SJ, Ussar S, et al. Lessons on conditional gene targeting in mouse adipose tissue. Diabetes 2013;62:864-874
19. Rodeheffer MS, Birsoy K, Friedman JM. Identification of white adipocyte progenitor cells in vivo. Cell 2008;135:240-249
20. Whittle AJ, Carobbio S, Martins L, et al. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell 2012;149:871-885
21. Wang ZV, Deng Y, Wang QA, Sun K, Scherer PE. Identification and characterization of a promoter cassette conferring adipocyte-specific gene expression. Endocrinology 2010;151:2933-2939
22. Pagès G, Girard A, Jeanneton O, et al. LPA as a paracrine mediator of adipocyte growth and function. Ann N Y Acad Sci 2000;905:159-164
23. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003;112:1796-1808
24. Dennis J, White MA, Forrest AD, et al. Phosphodiesterase-Ialpha/autotaxin's MORFO domain regulates oligodendroglial process network formation and focal adhesion organization. Mol Cell Neurosci 2008;37:412-424
25. Haluzik M, Colombo C, Gavrilova O, et al. Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology 2004;145:3258-3264
26. Lundgren M, Svensson M, Lindmark S, Renström F, Ruge T, Eriksson JW. Fat cell enlargement is an independent marker of insulin resistance and 'hyperleptinaemia'. Diabetologia 2007;50:625-633
27. Arner E, Westermark PO, Spalding KL, et al. Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes 2010;59:105-109