Calcium-mediated histone modifications regulate alternative splicing in cardiomyocytes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 46, 2014, Pages E4920-E4928

  Sharma, Alok ^a   Nguyen, Hieu ^a   Geng, Cuiyu ^a   Hinman, Melissa N ^a   Luo, Guangbin ^a   Lou, Hua ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alternative splicing; Calcium; Cardiomyocytes; Histone hyperacetylation; Transcriptional elongation rate

Indexed keywords

ACYLTRANSFERASE; CALCIUM; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; HISTONE ACYLTRANSFERASE; HISTONE DEACETYLASE; POLYCYSTIN 1; RNA POLYMERASE II; UNCLASSIFIED DRUG; HISTONE; MESSENGER RNA; NEUROFIBROMIN; POLYCYSTIC KIDNEY DISEASE 1 PROTEIN; POLYCYSTIN; POTASSIUM CHLORIDE; PROTEIN KINASE INHIBITOR; SMALL INTERFERING RNA;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL MEMBRANE DEPOLARIZATION; CELL NUCLEUS; CONTROLLED STUDY; EMBRYONIC STEM CELL; EXON SKIPPING; GENE EXPRESSION; HEART MUSCLE CELL; HISTONE ACETYLATION; MOUSE; NONHUMAN; TRANSCRIPTION ELONGATION; ACETYLATION; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; EXON; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN PROCESSING; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ACETYLATION; ALTERNATIVE SPLICING; ANIMALS; CALCIUM SIGNALING; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; EXONS; GENE EXPRESSION REGULATION; GENES, NEUROFIBROMATOSIS 1; HISTONE DEACETYLASES; HISTONES; MICE; MYOCYTES, CARDIAC; NEUROFIBROMIN 1; POTASSIUM CHLORIDE; PROTEIN KINASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; REAL-TIME POLYMERASE CHAIN REACTION; RNA POLYMERASE II; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION ELONGATION, GENETIC; TRPP CATION CHANNELS;

EID: 84911875903     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1408964111     Document Type: Article

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