Sporozoite immunization of human volunteers under mefloquine prophylaxis is safe, immunogenic and protective: A Double-Blind randomized controlled clinical trial

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Bijker, Else M ^a   Schats, Remko ^b   Obiero, Joshua M ^a   Behet, Marije C ^a   Van Gemert, Geert Jan ^a   Van De Vegte Bolmer, Marga ^a   Graumans, Wouter ^a   Van Lieshout, Lisette ^b   Bastiaens, Guido J H ^a   Teelen, Karina ^a   Hermsen, Cornelus C ^a   Scholzen, Anja ^a   Visser, Leo G ^b   Sauerwein, Robert W ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; CIRCUMSPOROZOITE PROTEIN; GAMMA INTERFERON; LIVER STAGE ANTIGEN 1; MALARIA VACCINE; MEFLOQUINE; MEROZOITE SURFACE PROTEIN 1; PARASITE ANTIGEN; UNCLASSIFIED DRUG; ANTIBODY; ANTIMALARIAL AGENT; GRANZYME; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; PROTOZOAL DNA;

ADAPTIVE IMMUNITY; ADULT; ANTIBODY RESPONSE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG POTENCY; DRUG SAFETY; DRUG TOLERABILITY; ERYTHROCYTE; FEMALE; HUMAN; HUMAN EXPERIMENT; IMMUNOGENICITY; IMMUNOLOGICAL MEMORY; INNATE IMMUNITY; INTERFERON PRODUCTION; MALARIA CONTROL; MALARIA FALCIPARUM; MALE; MOSQUITO BITE; NONHUMAN; NORMAL HUMAN; PLASMODIUM FALCIPARUM; RANDOMIZED CONTROLLED TRIAL; SPOROZOITE; VACCINATION; YOUNG ADULT; ADOLESCENT; BLOOD; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL TRIAL; GENETICS; IMMUNOLOGY; MALARIA, FALCIPARUM; METABOLISM; PARASITOLOGY; PHYSIOLOGY;

ADOLESCENT; ADULT; ANTIBODIES; ANTIMALARIALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHLOROQUINE; DNA, PROTOZOAN; DOUBLE-BLIND METHOD; ERYTHROCYTES; GRANZYMES; HEALTHY VOLUNTEERS; HUMANS; IMMUNITY, CELLULAR; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1; MALARIA, FALCIPARUM; MALE; MEFLOQUINE; PLASMODIUM FALCIPARUM; SPOROZOITES; YOUNG ADULT;

EID: 84911875202     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0112910     Document Type: Article

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