Tolerability of malaria chemoprophylaxis in non-immune travellers to sub-Saharan Africa: Multicentre, randomised, double blind, four arm study

British Medical Journal

Volumn 327, Issue 7423, 2003, Pages 1078-1081

  Schlagenhauf, Patricia ^a   Tschopp, Alois ^a   Johnson, Richard ^b   Nothdurft, Hans D ^c   Beck, Bernhard ^d   Schwartz, Eli ^e   Herold, Markus ^a   Krebs, Bjarne ^c   Veit, Olivia ^d   Allwinn, Regina ^f   Steffen, Robert ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b US Army Research Institute of Environmental Medicine   (United States)

^c UNIVERSITY OF MUNICH   (Germany)

^d SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^e TEL AVIV UNIVERSITY   (Israel)

^f GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ATOVAQUONE; ATOVAQUONE PLUS PROGUANIL; CHLOROQUINE; CHLOROQUINE PLUS PROGUANIL; DOXYCYCLINE; MEFLOQUINE; PLACEBO; PROGUANIL;

ADULT; AFRICA; AGED; ANXIETY DISORDER; ARTICLE; CHEMOPROPHYLAXIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG SAFETY; DRUG TOLERABILITY; ERYTHEMA; GASTROINTESTINAL TOXICITY; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; MALARIA; MOUTH ULCER; MULTICENTER STUDY; NAUSEA; NEUROTOXICITY; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SKIN TOXICITY; SLEEP DISORDER; TRAVEL; TREATMENT OUTCOME; VERTIGO; VISUAL DISORDER;

ADOLESCENT; ADULT; AFRICA SOUTH OF THE SAHARA; AGED; ANTIMALARIALS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; GERMANY; HUMANS; ISRAEL; MALARIA; MALE; MIDDLE AGED; SWITZERLAND; TRAVEL;

EID: 0037802243     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Muentener P, Schlagenhauf P, Steffen R. Imported malaria (1985-95): trends and perspectives. Bull WHO 1999;77:560-6.
2. World Health Organization. International travel and health 2002. Geneva: WHO, 2002.
3. Bradley DJ, Bannister B. Guidelines for malaria prevention in travellers from the United Kingdom for 2001. Commun Dis Public Health 2001;4:84-101.
4. Centers for Disease Control. Malaria. In: Health information for international travel. Atlanta: US Department of Health and Human Services, 2001.
5. Committee to Advise on Tropical Medicine and Travel. Canadian recommendations for the prevention and treatment of malaria among international travelers. Ottawa, Canada: Health Canada, 2001.
6. Overbosch D, Schilthuis H, Bienzle U, Behrens RH, Kain KC, Clarke PD, et al. Atovaquone-proguanil versus mefloquine for malaria prophylaxis in non-immune travelers: results from a randomized, double-blind study. Clin Infect Dis 2001;33:1015-21.
7. Hogh B, Clarke PD, Camus D, Nothdurft HD, Overbosch D, Gunther M, et al. Atovaquone-proguanil vs chloroquine-proguanil for malaria prophylaxis in non-immune travellers: a randomised, double-blind study. Lancet 2000;356:1888-94.
8. Barrett PJ, Emmins PD, Clarke PD, Bradley DJ Comparison of adverse events associated with the use of mefloquine and combination of chloroquine and proguanil as anti-malarial prophylaxis: postal and telephone survey of travellers. BMJ 1996;313:525-8.
9. Schlagenhauf P, Steffen R, Lobel H, Johnson R, Letz R, Tschopp A, et al. Mefloquine tolerability during chemoprophylaxis, focus on adverse event assessments, stereochemistry and compliance. Trop Med Int Health 1996;1:485-94.
10. Boudreau E, Schuster B, Sanchez J, Novakowski W, Johnson R, Redmond D, et al. Tolerability of prophylactic Lariam regimens. Trop Med Parasitol 1993;44:257-65.
11. Shanks GD. Atovaquone/proguanil. In: Schlagenhauf P, ed. Travelers' malaria. London: Decker, 2001:227-47.
12. Pang LW, Limsomwong N, Boudreau EF, Singharaj P. Doxycycline prophylaxis for falciparum malaria. Lancet 1987;1:1161-4.
13. Pang LW, Limsomwong N, Singharaj P. Prophylactic treatment of vivax and falciparum malaria with low-dose doxycycline. J Infect Dis 1988;158:1124-7.
14. Weiss WR, Oloo AJ, Johnson A, Koech D, Hoffman SL. Daily primaquine is effective for prophylaxis against falciparum malaria in Kenya: comparison with mefloquin, doxycycline, and chloroquin/proguanil. J Infect Dis 1995;171:1569-75.
15. Ohrt C, Ritchie TI, Widjaja H, Shanks GD, Fitriadi J, Fryauff DJ, et al. Mefloquine compared with doxycycline for the prophylaxis of malaria in Indonesia soldiers. Ann Intern Med 1997;126:963-72.
16. Anderson SL, Oloo AJ, Gordon DM, Ragama OB, Aleman GM, Berman JD, et al. Successful double-blinded, randomized, placebo-controlled field trial of azithromycin and doxycycline as prophylaxis for malaria in western Kenya. Clin Infect Dis 1998;26:146-50.
17. Taylor WR, Richie TL, Fryauff DJ, Piraeima H, Ohrt C, Tang D, et al. Malaria prophylaxis using azithromycin: a double-blind, placebo controlled trial in Irian Jaya, Indonesia. Clin Infect Dis 1999;28:74-81.
18. Nasveld PE, Edstein MD, Kitcher SJ, Rieckmann KH. Comparison of the effectiveness of atovaquone/proguanil combination and doxycycline in the chemoprophylaxis of malaria in Australian defense force personnel. Proceedings of the 49th annual meeting of the American Society of Tropical Medicine and Hygiene, 29 Oct to 2 Nov, 2000, Houston, TX. Am J Trop Med Hyg Suppl 2000. [Abstract No 1391.]
19. Arthur JD, Echeverria P, Shanks GD, Karwacki J, Bodhidatta L, Brown JE, et al. A comparative study of gastrointestinal infections in United States soldiers receiving doxycycline or mefloquine for malaria prophylaxis. Am J Trop Med Hyg 1990;43:606-18.
20. Wallace MR, Sharp TW, Smoak B, Iriye C, Rozmajzl P, Thornton SH, et al. Malaria among United States troops in Somalia. Am J Med 1996;100:49-55.
21. Phillips MA, Kass RB. User acceptability patterns for mefloquine and doxycycline malaria chemoprophylaxis. J Travel Med 1996;3:40-5.
22. Croft AM, Garner P. Mefloquine for preventing malaria in non-immune adult travellers. Cochrane Database Syst Rev 2001;(1):CD00138.
23. Schlagenhauf P. Mefloquine for malaria chemoprophylaxis 1992-1998: a review. J Travel Med 1999;6:122-33.
24. Petersen E, Ronne T, Ronn A, Bygbjerg I, Larsen SO. Reported side effects to chloroquine, chloroquine plus proguanil, and mefloquine as chemoprophylaxis against malaria in Danish travelers. J Travel Med 2000;7:79-84.