Increased D-serine in the aqueous and vitreous humour in patients with proliferative diabetic retinopathy

Clinical and Experimental Ophthalmology

Volumn 42, Issue 9, 2014, Pages 841-845

  Jiang, Haiyan ^a,b   Du, Jinlin ^a,b   He, Tao ^a,b   Qu, Jia ^a,b   Song, Zongming ^a,b   Wu, Shengzhou ^a,b  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b BEIJING HOSPITAL   (China)

Author keywords

Diabetic retinopathy; Excitotoxicity; Glutamate; Retinal neuronal death; Serine racemase

Indexed keywords

DEXTRO SERINE; GLUTAMIC ACID; HEMOGLOBIN; SERINE;

ADULT; AGED; AQUEOUS HUMOR; ARTICLE; CASE CONTROL STUDY; CLINICAL ARTICLE; CLINICAL STUDY; CONTROLLED STUDY; DIABETIC RETINOPATHY; EPIRETINAL MEMBRANE; FEMALE; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HUMAN; IDIOPATHIC DISEASE; MALE; MIDDLE AGED; OPHTHALMOLOGIST; PARS PLANA VITRECTOMY; RETINA MACULA HOLE; RETROSPECTIVE STUDY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SPECTROPHOTOMETRY; VITRECTOMY; VITREOUS BODY; VITREOUS HEMORRHAGE; COMPLICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSULIN DEPENDENT DIABETES MELLITUS; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOLOGY; RETINA NEOVASCULARIZATION;

AGED; AQUEOUS HUMOR; CASE-CONTROL STUDIES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; FEMALE; GLUTAMIC ACID; HUMANS; MALE; MIDDLE AGED; RETINAL NEOVASCULARIZATION; RETROSPECTIVE STUDIES; SERINE; VITREOUS BODY;

EID: 84911493796     PISSN: 14426404     EISSN: 14429071     Source Type: Journal    
DOI: 10.1111/ceo.12329     Document Type: Article

References (21)

1. Archer DB. Bowman Lecture 1998. Diabetic retinopathy: some cellular, molecular and therapeutic considerations. Eye (Lond) 1999; 13 (Pt 4): 497-523.
2. Cai J, Boulton M. The pathogenesis of diabetic retinopathy: old concepts and new questions. Eye (Lond) 2002; 16: 242-260.
3. Kusari J, Zhou S, Padillo E, Clarke KG, Gil DW. Effect of memantine on neuroretinal function and retinal vascular changes of streptozotocin-induced diabetic rats. Invest Ophthalmol Vis Sci 2007; 48: 5152-5159.
4. Barber AJ. A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuropsychopharmacol Biol Psychiatry 2003; 27: 283-290.
5. Moore P, El-sherbeny A, Roon P, Schoenlein PV, Ganapathy V, Smith SB. Apoptotic cell death in the mouse retinal ganglion cell layer is induced in vivo by the excitatory amino acid homocysteine. Exp Eye Res 2001; 73: 45-57.
6. Ambati J, Chalam KV, Chawla DK etal. Elevated gamma-aminobutyric acid, glutamate, and vascular endothelial growth factor levels in the vitreous of patients with proliferative diabetic retinopathy. Arch Ophthalmol 1997; 115: 1161-1166.
7. Lieth E, Barber AJ, Xu B etal. Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group. Diabetes 1998; 47: 815-820.
8. Kowluru RA, Engerman RL, Case GL, Kern TS. Retinal glutamate in diabetes and effect of antioxidants. Neurochem Int 2001; 38: 385-390.
9. Santiago AR, Gaspar JM, Baptista FI etal. Diabetes changes the levels of ionotropic glutamate receptors in the rat retina. Mol Vis 2009; 15: 1620-1630.
10. Santiago AR, Hughes JM, Kamphuis W, Schlingemann RO, Ambrosio AF. Diabetes changes ionotropic glutamate receptor subunit expression level in the human retina. Brain Res 2008; 1198: 153-159.
11. Wu SZ, Bodles AM, Porter MM, Griffin WS, Basile AS, Barger SW. Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide. J Neuroinflammation 2004; 1: 2.
12. Wu SZ, Jiang S, Sims TJ, Barger SW. Schwann cells exhibit excitotoxicity consistent with release of NMDA receptor agonists. J Neurosci Res 2005; 79: 638-643.
13. Inoue R, Hashimoto K, Harai T, Mori H. NMDA- and beta-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice. J Neurosci 2008; 28: 14486-14491.
14. Mustafa AK, Ahmad AS, Zeynalov E etal. Serine racemase deletion protects against cerebral ischemia and excitotoxicity. J Neurosci 2010; 30: 1413-1416.
15. Stevens ER, Esguerra M, Kim PM etal. D-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors. Proc Natl Acad Sci U S A 2003; 100: 6789-6794.
16. Hama Y, Katsuki H, Tochikawa Y, Suminaka C, Kume T, Akaike A. Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo. Neurosci Res 2006; 56: 279-285.
17. Jiang H, Fang J, Wu B etal. Overexpression of serine racemase in retina and overproduction of D-serine in eyes of streptozotocin-induced diabetic retinopathy. J Neuroinflammation 2011; 8: 119.
18. Hashimoto K, Fukushima T, Shimizu E etal. Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia. Arch Gen Psychiatry 2003; 60: 572-576.
19. Hashimoto A, Nishikawa T, Oka T, Takahashi K, Hayashi T. Determination of free amino acid enantiomers in rat brain and serum by high-performance liquid chromatography after derivatization with N-tert.-butyloxycarbonyl-L-cysteine and o-phthaldialdehyde. J Chromatogr 1992; 582: 41-48.
20. Dun Y, Duplantier J, Roon P, Martin PM, Ganapathy V, Smith SB. Serine racemase expression and D-serine content are developmentally regulated in neuronal ganglion cells of the retina. J Neurochem 2008; 104: 970-978.
21. Kerrigan-Baumrind LA, Quigley HA, Pease ME, Kerrigan DF, Mitchell RS. Number of ganglion cells in glaucoma eyes compared with threshold visual field tests in the same persons. Invest Ophthalmol Vis Sci 2000; 41: 741-748.