A combination of HA and PA mutations enhances virulence in a mouse-adapted H6N6 influenza A virus

Journal of Virology

Volumn 88, Issue 24, 2014, Pages 14116-14125

  Tan, Likai ^a   Su, Shuo ^a   Smith, David K ^b   He, Shuyi ^a   Zheng, Yun ^a   Shao, Zhenwen ^a   Ma, Jun ^a   Zhu, Huachen ^b   Zhang, Guihong ^a  

^a SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

^b THE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

HEMAGGLUTININ; RIBONUCLEOPROTEIN; INFLUENZA VIRUS HEMAGGLUTININ; MUTANT PROTEIN; PA PROTEIN, INFLUENZA VIRUSES; RNA DIRECTED RNA POLYMERASE; VIRULENCE FACTOR; VIRUS PROTEIN;

A549 CELL LINE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EVOLUTIONARY ADAPTATION; FEMALE; GENE MUTATION; GENE SEQUENCE; HA GENE; HEK293 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLUENZA VIRUS A; INFLUENZA VIRUS A H6N6; MDCK CELL LINE; MOLECULAR CLONING; MOUSE; NONHUMAN; PA GENE; PB2 GENE; POINT MUTATION; RNA TRANSCRIPTION; TRANSCRIPTION REGULATION; UPREGULATION; VIRUS GENE; VIRUS GENOME; VIRUS MUTATION; VIRUS REPLICATION; VIRUS VIRULENCE; WILD TYPE; ADAPTATION; ANIMAL; BAGG ALBINO MOUSE; BODY WEIGHT; CELL LINE; CYTOCHEMISTRY; DISEASE MODEL; DOG; GENETICS; INFLUENZA A VIRUS; ISOLATION AND PURIFICATION; ORTHOMYXOVIRUS INFECTION; PATHOGENICITY; PATHOLOGY; PIG; VIRAL PLAQUE ASSAY; VIROLOGY; VIRULENCE; VIRUS LOAD;

INFLUENZA A VIRUS;

ADAPTATION, BIOLOGICAL; ANIMALS; BODY WEIGHT; CELL LINE; DISEASE MODELS, ANIMAL; DOGS; FEMALE; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HISTOCYTOCHEMISTRY; HUMANS; INFLUENZA A VIRUS; MICE, INBRED BALB C; MUTANT PROTEINS; ORTHOMYXOVIRIDAE INFECTIONS; RNA REPLICASE; SWINE; VIRAL LOAD; VIRAL PLAQUE ASSAY; VIRAL PROTEINS; VIRULENCE; VIRULENCE FACTORS; VIRUS REPLICATION;

EID: 84911488432     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01736-14     Document Type: Article

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