17α-Estradiol is generated locally in the male rat brain and can regulate GAD65 expression and anxiety

Neuropharmacology

Volumn 90, Issue , 2015, Pages 9-14

  Ikeda, Takamitsu ^a   Makino, Yukiko ^a   Yamada, Maki K ^a,b,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

AKR1C; Anti anxiety; Aromatase; Estrogen; Female hormone; Inhibition

Indexed keywords

17ALPHA ESTRADIOL; ESTRADIOL; GLUTAMATE DECARBOXYLASE 65; LETROZOLE; CENTRAL NERVOUS SYSTEM AGENTS; ESTROGEN; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 2; NITRILE; TRIAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; BIOGENESIS; BRAIN; BRAIN LEVEL; CONTROLLED STUDY; DRUG EFFECT; ESTRADIOL BRAIN LEVEL; ESTROGEN SYNTHESIS; HIPPOCAMPUS; HORMONE ACTION; IMMUNOHISTOCHEMISTRY; MALE; MASS FRAGMENTOGRAPHY; NERVE CELL CULTURE; NEUROTRANSMISSION; NONHUMAN; OPEN FIELD TEST; PROTEIN EXPRESSION; RAT; ANIMAL; CELL CULTURE; DRUG EFFECTS; DRUG THERAPY; FLUORESCENCE MICROSCOPY; METABOLISM; MOTOR ACTIVITY; PATHOPHYSIOLOGY; PHYSIOLOGY; WISTAR RAT;

ANIMALS; ANXIETY; BRAIN; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM AGENTS; ESTRADIOL; ESTROGENS; GLUTAMATE DECARBOXYLASE; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, FLUORESCENCE; MOTOR ACTIVITY; NITRILES; RATS, WISTAR; TRIAZOLES;

EID: 84911481274     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.10.019     Document Type: Article

References (21)

1. J. Balthazart, and G.F. Ball Is brain estradiol a hormone or a neurotransmitter? Trends Neurosci. 29 2006 241 249
2. C.K. Barha, and L.A.M. Galea Influence of different estrogens on neuroplasticity and cognition in the hippocampus Biochimica Biophysica Acta-General Subj. 1800 2010 1056 1067
3. Y.C. Chang, and D.I. Gottlieb Characterization of the proteins purified with monoclonal antibodies to glutamic acid decarboxylase J. Neurosci. 8 1988 2123 2130
4. F. Courant, L. Aksglaede, J.P. Antignac, F. Monteau, K. Sorensen, A.M. Andersson, N.E. Skakkebaek, A. Juul, and B.L. Bizec Assessment of circulating sex steroid levels in prepubertal and pubertal boys and girls by a novel ultrasensitive gas chromatography-tandem mass spectrometry method J. Clin. Endocrinol. Metab. 95 2010 82 92
5. J.M. Daniel Estrogens, estrogen receptors, and female cognitive aging: the impact of timing Horm. Behav. 63 2013 231 237
6. F. Faucher, K. Pereira de Jesus-Tran, L. Cantin, V. Luu-The, F. Labrie, and R. Breton Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme J. Mol. Biol. 364 2006 747 763
7. L. Fester, J. Prange-Kiel, H. Jarry, and G.M. Rune Estrogen synthesis in the hippocampus Cell. Tissue Res. 345 2011 285 294
8. E.D. Hudgens, L. Ji, C.D. Carpenter, and S.L. Petersen The gad2 promoter is a transcriptional target of estrogen receptor (ER) alpha and ER beta: a unifying hypothesis to explain diverse effects of estradiol J. Neurosci. 29 2009 8790 8797
9. T. Ikeda, N. Matsuki, and M.K. Yamada Estrogen produced in cultured hippocampal neurons is a functional regulator of a GABAergic machinery J. Neurosci. Res. 84 2006 1771 1777
10. G.G. Kuiper, B. Carlsson, K. Grandien, E. Enmark, J. Haggblad, S. Nilsson, and J.A. Gustafsson Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta Endocrinology 138 1997 863 870
11. Y.Q. Liang, M. Akishita, S. Kim, J. Ako, M. Hashimoto, K. Iijima, Y. Ohike, T. Watanabe, N. Sudoh, K. Toba, M. Yoshizumi, and Y. Ouchi Estrogen receptor beta is involved in the anorectic action of estrogen Int. J. Obes. Relat. Metab. Disord. 26 2002 1103 1109
12. R.B. Lingham, G.M. Stancel, and D.S. Loose-Mitchell Estrogen regulation of epidermal growth factor receptor messenger ribonucleic acid Mol. Endocrinol 2 1988 230 235
13. N.H. Nakamura, D.R. Rosell, K.T. Akama, and B.S. McEwen Estrogen and ovariectomy regulate mRNA and protein of glutamic acid decarboxylases and cation-chloride cotransporters in the adult rat hippocampus Neuroendocrinology 80 2004 308 323
14. S. Ohba, T. Ikeda, Y. Ikegaya, N. Nishiyama, N. Matsuki, and M.K. Yamada BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition Cereb. Cortex 15 2005 291 298
15. O. Paulsen, and E.I. Moser A model of hippocampal memory encoding and retrieval: GABAergic control of synaptic plasticity Trends Neurosci. 21 1998 273 278
16. S. Royer, B.V. Zemelman, A. Losonczy, J. Kim, F. Chance, J.C. Magee, and G. Buzsaki Control of timing, rate and bursts of hippocampal place cells by dendritic and somatic inhibition Nat. Neurosci. 15 2012 769 775
17. C.N. Rudick, and C.S. Woolley Estrogen regulates functional inhibition of hippocampal CA1 pyramidal cells in the adult female rat J. Neurosci. 21 2001 6532 6543
18. M.A. Snyder, T. Smejkalova, P.M. Forlano, and C.S. Woolley Multiple ERbeta antisera label in ERbeta knockout and null mouse tissues J. Neurosci. Methods 188 2010 226 234
19. D.P. Srivastava, K.M. Woolfrey, and P. Penzes Insights into rapid modulation of neuroplasticity by brain estrogens Pharmacol. Rev. 65 2013 1318 1350
20. C.D. Toran-Allerand, A.A. Tinnikov, R.J. Singh, and I.S. Nethrapalli 17alpha-estradiol: a brain-active estrogen? Endocrinology 146 2005 3843 3850
21. M.D. Womble, J.A. Andrew, and J.J. Crook 17beta-Estradiol reduces excitatory postsynaptic potential (EPSP) amplitude in rat basolateral amygdala neurons Neurosci. Lett. 331 2002 83 86