Human recombinant cytochrome P450 enzymes display distinct hydrogen peroxide generating activities during substrate independent NADPH oxidase reactions

Toxicological Sciences

Volumn 141, Issue 2, 2014, Pages 344-352

  Mishin, Vladimir ^a   Heck, Diane E ^b   Laskin, Debra L ^a   Laskin, Jeffrey D ^a,c  

^a RUTGERS UNIVERSITY   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Oxidase reaction; Cytochrome P450; Cytochrome P450 reductase; Microsomes; Reactive oxygen species

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2A6; CYTOCHROME P450 2C; CYTOCHROME P450 2C18; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 2J2; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 3A7; CYTOCHROME P450 4A11; HYDROGEN PEROXIDE; RECOMBINANT ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ISOENZYME; RECOMBINANT PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER MICROSOME; OXIDATIVE STRESS; PROTEIN EXPRESSION; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; KINETICS; LIVER; METABOLISM;

CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; HYDROGEN PEROXIDE; ISOENZYMES; KINETICS; LIVER; MICROSOMES, LIVER; NADPH-FERRIHEMOPROTEIN REDUCTASE; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 84911478922     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu133     Document Type: Article

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