Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature

Development (Cambridge)

Volumn 141, Issue 23, 2014, Pages 4610-4617

  Delgado Olguín, Paul ^a,b,c,d   Dang, Lan T ^c,d,e   He, Daniel ^a   Thomas, Sean ^a   Chi, Lijun ^b   Sukonnik, Tatyana ^a   Khyzha, Nadiya ^c,d,e   Dobenecker, Marc Werner ^f   Fish, Jason E ^c,d,e   Bruneau, Benoit G ^a,g,h  

^a GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d HEART AND STROKE FOUNDATION OF CANADA   (Canada)

^e UNIVERSITY HEALTH NETWORK   (Canada)

^f ROCKEFELLER UNIVERSITY   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Endothelium; Epigenetics; Extracellular matrix; Ezh2; Histone methylation; Mmp9; Mouse; Vascular development; Vascular stability

Indexed keywords

GELATINASE B; HISTONE METHYLTRANSFERASE; KRUPPEL LIKE FACTOR 5; PROTEIN FOS; TRANSCRIPTION FACTOR EZH2; CREB3L1 PROTEIN, MOUSE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EZH2 PROTEIN, MOUSE; KLF5 PROTEIN, MOUSE; KRUPPEL LIKE FACTOR; LUCIFERASE; MMP9 PROTEIN, MOUSE; NERVE PROTEIN; ORGANIC COMPOUND; POLYCOMB REPRESSIVE COMPLEX 2; PRIMER DNA; PROTEIN C FOS; SYBR GREEN I; TRANSCRIPTION FACTOR FRA 1;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; EPIGENETICS; EXTRACELLULAR MATRIX; GENE INACTIVATION; GENE REPRESSION; GENETIC TRANSCRIPTION; HISTONE METHYLATION; MOUSE; NONHUMAN; VASCULARIZATION; ANIMAL; BLOOD VESSEL; CHROMATIN IMMUNOPRECIPITATION; EMBRYOLOGY; EPIGENETIC REPRESSION; GENE EXPRESSION REGULATION; GENETICS; IN SITU HYBRIDIZATION; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

ANIMALS; BLOOD VESSELS; BLOTTING, WESTERN; CHROMATIN IMMUNOPRECIPITATION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA PRIMERS; EPIGENETIC REPRESSION; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION, DEVELOPMENTAL; IN SITU HYBRIDIZATION; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LUCIFERASES; MATRIX METALLOPROTEINASE 9; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; NERVE TISSUE PROTEINS; ORGANIC CHEMICALS; POLYCOMB REPRESSIVE COMPLEX 2; PROTO-ONCOGENE PROTEINS C-FOS; REAL-TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, RNA; SIGNAL TRANSDUCTION;

EID: 84911468824     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.112607     Document Type: Article

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