Biochemical characterization of pathogenic mutations in human mitochondrial methionyl-tRNA formyltransferase

Journal of Biological Chemistry

Volumn 289, Issue 47, 2014, Pages 32729-32741

  Sinha, Akesh ^a   Köhrer, Caroline ^a   Weber, Michael H W ^a   Masuda, Isao ^b   Mootha, Vamsi K ^c   Hou, Ya Ming ^b   RajBhandary, Uttam L ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ESCHERICHIA COLI; GENE ENCODING; GENES;

BIOCHEMICAL CHARACTERIZATION; LEIGH SYNDROME; MITOCHONDRIAL PROTEIN; OXIDATIVE PHOSPHORYLATION; PATHOGENIC MUTATION; RESIDUAL ACTIVITY; TRANSLATION SYSTEMS; TRANSLATIONAL EFFICIENCIES;

MITOCHONDRIA;

BETA LACTAMASE; CHLORAMPHENICOL ACETYLTRANSFERASE; METHIONYL TRANSFER RNA FORMYLTRANSFERASE; TRANSFERASE; UNCLASSIFIED DRUG; ALANINE; ESCHERICHIA COLI PROTEIN; METHIONINE TRANSFER RNA; METHIONYL-TRNA FORMYLTRANSFERASE; MITOCHONDRIAL PROTEIN; SERINE;

ARTICLE; BACTERIAL STRAIN; BINDING AFFINITY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ESCHERICHIA COLI; FORMYLATION; GENETIC TRANSFORMATION; HETEROZYGOSITY; HOMOZYGOSITY; MITOCHONDRION; MUTATION; NONHUMAN; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; SEQUENCE ALIGNMENT; TRANSCRIPTION ELONGATION; TRANSLATION INITIATION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; GENETICS; HUMAN; IMMUNOBLOTTING; LEIGH DISEASE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SEQUENCE HOMOLOGY;

ALANINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BASE SEQUENCE; ESCHERICHIA COLI PROTEINS; HUMANS; HYDROXYMETHYL AND FORMYL TRANSFERASES; IMMUNOBLOTTING; LEIGH DISEASE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BIOSYNTHESIS; RNA, TRANSFER, MET; SEQUENCE HOMOLOGY, AMINO ACID; SERINE;

EID: 84911454736     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.610626     Document Type: Article

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