Transformation of methadone and its main human metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), during water chlorination

Water Research

Volumn 68, Issue , 2015, Pages 759-770

  González Mariño, Iria ^a,b   Quintana, José Benito ^b   Rodríguez, Isaac ^b   Cores, Miriam ^b   Cela, Rafael ^b  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

2 ethylidene 1,5 dimethyl 3,3 diphenylpyrrolidine (EDDP); Chlorination; Environmental fate; Liquid chromatography time of flight mass spectrometry; Methadone; Transformation products

Indexed keywords

BIOGEOCHEMISTRY; BIOMOLECULES; CHLORINATION; CHLORINE; CHROMATOGRAPHIC ANALYSIS; DIRECT INJECTION; DRUG PRODUCTS; HUMAN REACTION TIME; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; ORGANIC COMPOUNDS;

2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE (EDDP); ENVIRONMENTAL FATE; LIQUID CHROMATOGRAPHY TIME-OF-FLIGHT MASS SPECTROMETRIES; METHADONE; TRANSFORMATION PRODUCTS;

REACTION KINETICS;

2 ETHYLIDENE 1,5 DIMETHYL 3,3 DIPHENYLPYRROLIDINE; DRUG METABOLITE; METHADONE; RIVER WATER; SURFACE WATER; 2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE; CHLORINE; FRESH WATER; NARCOTIC ANALGESIC AGENT; PYRROLIDINE DERIVATIVE; WATER; WATER POLLUTANT;

CHLORINATION; DISSOLVED ORGANIC MATTER; DRUG; ECOTOXICOLOGY; ENVIRONMENTAL FATE; METABOLITE; PH; REACTION KINETICS; TRANSFORMATION;

ARTICLE; CHLORINATION; DRUG ABUSE; ECOTOXICITY; ENVIRONMENTAL IMPACT; LIQUID CHROMATOGRAPHY; REACTION TIME; SPAIN; TIME OF FLIGHT MASS SPECTROMETRY; TOXICOKINETICS; WASTE WATER; WATER SAMPLING; WATER TREATMENT; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CYPRINIDAE; DAPHNIA; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HALOGENATION; HUMAN; KINETICS; MASS SPECTROMETRY; METABOLISM; PH; PROCEDURES; RIVER; SEWAGE; TOXICITY; TOXICITY TESTING; WATER POLLUTANT;

ANALGESICS, OPIOID; ANIMALS; CHLORINE; CHROMATOGRAPHY, LIQUID; CYPRINIDAE; DAPHNIA; FRESH WATER; HALOGENATION; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MASS SPECTROMETRY; METHADONE; MOLECULAR STRUCTURE; PYRROLIDINES; RIVERS; TOXICITY TESTS; WASTE DISPOSAL, FLUID; WATER; WATER POLLUTANTS, CHEMICAL;

EID: 84911448879     PISSN: 00431354     EISSN: 18792448     Source Type: Journal    
DOI: 10.1016/j.watres.2014.10.058     Document Type: Article

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