A kinetic-based approach to understanding heterologous mevalonate pathway function in E. coli

Biotechnology and Bioengineering

Volumn 112, Issue 1, 2015, Pages 111-119

  Weaver, Lane J ^a,b   Sousa, Mirta M L ^a,d,e   Wang, George ^a,c   Baidoo, Edward ^a,c   Petzold, Christopher J ^a,c   Keasling, Jay D ^a,b,c  

^a JOINT BIOENERGY INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^d NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^e NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Isoprenoids; Kinetic modeling; Metabolic engineering; Proteomics

Indexed keywords

DIFFERENTIAL EQUATIONS; ENZYMES; ESCHERICHIA COLI; KINETICS; MASS SPECTROMETRY; METABOLIC ENGINEERING; METABOLISM; MOLECULAR BIOLOGY; ORDINARY DIFFERENTIAL EQUATIONS; PRODUCTIVITY; RATE CONSTANTS; SENSITIVITY ANALYSIS; STRAIN;

EXPERIMENTAL INVESTIGATIONS; FARNESYL PYROPHOSPHATES; GLOBAL SENSITIVITY ANALYSIS; ISOPRENOIDS; KINETIC MODELING; ORDINARY DIFFERENTIAL EQUATION MODELS; PROTEOMICS; SELECTIVE REACTION MONITORING;

ENZYME INHIBITION;

FARNESYL DIPHOSPHATE; MEVALONATE KINASE; AMORPHA-4,11-DIENE SYNTHASE; MEVALONIC ACID; TERPENE; TRANSFERASE;

ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; IN VIVO STUDY; KINETICS; MASS SPECTROMETRY; METABOLIC ENGINEERING; METABOLISM; NEGATIVE FEEDBACK; NONHUMAN; PREDICTION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUALITATIVE ANALYSIS; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; FEEDBACK SYSTEM; GENETICS; PROCEDURES; PROTEOMICS;

ALKYL AND ARYL TRANSFERASES; ESCHERICHIA COLI; FEEDBACK, PHYSIOLOGICAL; KINETICS; METABOLIC ENGINEERING; MEVALONIC ACID; PROTEOMICS; TERPENES;

EID: 84911430915     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25323     Document Type: Article

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