Blood α-synuclein in agricultural pesticide handlers in central Washington State

Environmental Research

Volumn 136, Issue , 2015, Pages 75-81

  Searles Nielsen, Susan ^a   Checkoway, Harvey ^b   Zhang, Jing ^a   Hofmann, Jonathan N ^c   Keifer, Matthew C ^d   Paulsen, Michael ^a   Farin, Federico M ^a   Cook, Travis J ^a   Simpson, Christopher D ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d MARSHFIELD CLINIC   (United States)

Author keywords

Aryldialkylphosphatase; Chlorpyrifos; Parkinson disease; Pesticides; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; PESTICIDE;

BLOOD; CROSS SECTION; DOSE-RESPONSE RELATIONSHIP; ENVIRONMENTAL FACTOR; ENZYME ACTIVITY; GENOTYPE; INHIBITION; INSECTICIDE; NUMERICAL MODEL; OCCUPATIONAL EXPOSURE; PESTICIDE; POLLUTION EXPOSURE;

ADULT; AGRICULTURAL PESTICIDE HANDLER; AGRICULTURAL WORKER; ALLELE; ARTICLE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ENVIRONMENTAL FACTOR; EXPLORATORY RESEARCH; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISPANIC; HUMAN; HUMAN EXPERIMENT; LIMIT OF DETECTION; MALE; NORMAL HUMAN; OCCUPATIONAL EXPOSURE; PROTEIN BLOOD LEVEL; SELF REPORT; TANDEM MASS SPECTROMETRY; UNITED STATES; AGRICULTURE; BLOOD; TOXICITY;

UNITED STATES; WASHINGTON [UNITED STATES];

AGRICULTURE; ALPHA-SYNUCLEIN; HUMANS; MALE; OCCUPATIONAL EXPOSURE; PESTICIDES; WASHINGTON;

EID: 84911430620     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2014.10.014     Document Type: Article

References (35)

1. Allen M.T., Levy L.S. Parkinson's disease and pesticide exposure-a new assessment. Crit. Rev. Toxicol. 2013, 43:515-534.
2. Barbour R., Kling K., Anderson J.P., Banducci K., Cole T., Diep L., Fox M., Goldstein J.M., Soriano F., Seubert P., Chilcote T.J. Red blood cells are the major source of alpha-synuclein in blood. Neurodegener Dis. 2008, 5:55-59.
3. Bové J., Perier C. Neurotoxin-based models of Parkinson's disease. Neuroscience 2012, 211:51-76.
4. Chorfa A., Bétemps D., Morignat E., Lazizzera C., Hogeveen K., Andrieu T., Baron T. Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines. Toxicol. Sci. 2013, 133:289-297.
5. Costa L.G., Giordano G., Cole T.B., Marsillach J., Furlong C.E. Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity. Toxicology 2013, 307:115-122.
6. Deakin S., Leviev I., Brulhart-Meynet M.C., James R.W. Paraoxonase-1 promoter haplotypes and serum paraoxonase: a predominant role for polymorphic position-107, implicating the Sp1 transcription factor. Biochem. J. 2003, 372:643-649.
7. Eaton D.L., Daroff R.B., Autrup H., Bridges J., Buffler P., Costa L.G., Coyle J., McKhann G., Mobley W.C., Nadel L., Neubert D., Schulte-Hermann R., Spencer P.S. Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Crit. Rev. Toxicol. 2008, 38(Suppl. 2):1-125.
8. Elbaz A., Bower J.H., Maraganore D.M., McDonnell S.K., Peterson B.J., Ahlskog J.E., Schaid D.J., Rocca W.A. Risk tables for parkinsonism and Parkinson's disease. J. Clin. Epidemiol. 2002, 55:25-31.
9. Fuchs J., Tichopad A., Golub Y., Munz M., Schweitzer K.J., Wolf B., Berg D., Mueller J.C., Gasser T. Genetic variability in the SNCA gene influences α-synuclein levels in the blood and brain. FASEB 2008, 22:1327-1334.
10. Hofmann J.N., Keifer M.C., Furlong C.E., De Roos A.J., Farin F.M., Fenske R.A., van Belle G., Checkoway H. Serum cholinesterase inhibition in relation to paraoxonase-1 (PON1) status among organophosphate-exposed agricultural pesticide handlers. Environ. Health Perspect. 2009, 117:1402-1408.
11. Hofmann J.N., Checkoway H., Borges O., Servin F., Fenske R.A., Keifer M.C. Development of a computer-based survey instrument for organophosphate and N-methyl-carbamate exposure assessment among agricultural pesticide handlers. Ann. Occup. Hyg. 2010, 54:640-650.
12. Hofmann J.N., Keifer M.C., De Roos A.J., Fenske R.A., Furlong C.E., van Belle G., Checkoway H. Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington State. Occup. Environ. Med. 2010, 67:375-386.
13. Hong Z., Shi M., Chung K.A., Quinn J.F., Peskind E.R., Galasko D., Jankovic J., Zabetian C.P., Leverenz J.B., Baird G., Montine T.J., Hancock A.M., Hwang H., Pan C., Bradner J., Kang U.J., Jensen P.H., Zhang J. DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. Brain 2010, 133:713-726.
14. Jensen P.H., Islam K., Kenney J., Nielsen M.S., Power J., Gai W.P. Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments. J. Biol. Chem. 2000, 275:21500-21507.
15. Jowaed A., Schmitt I., Kaut O., Wüllner U. Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains. J. Neurosci. 2010, 30:6355-6359.
16. Linnertz C., Saucier L., Ge D., Cronin K.D., Burke J.R., Browndyke J.N., Hulette C.M., Welsh-Bohmer K.A., Chiba-Falek O. Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues. PLoS One 2009, 4:e7480.
17. Maraganore D.M., de Andrade M., Elbaz A., Farrer M.J., Ioannidis J.P., Krüger R., Rocca W.A., Schneider N.K., Lesnick T.G., Lincoln S.J., Hulihan M.M., Aasly J.O., Ashizawa T., Chartier-Harlin M.C., Checkoway H., Ferrarese C., Hadjigeorgiou G., Hattori N., Kawakami H., Lambert J.C., Lynch T., Mellick G.D., Papapetropoulos S., Parsian A., Quattrone A., Riess O., Tan E.K., Van Broeckhoven C. Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease. J. Am. Med. Assoc. 2006, 296:661-670. Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium.
18. Mata I.F., Shi M., Agarwal P., Chung K.A., Edwards K.L., Factor S.A., Galasko D.R., Ginghina C., Griffith A., Higgins D.S., Kay D.M., Kim H., Leverenz J.B., Quinn J.F., Roberts J.W., Samii A., Snapinn K.W., Tsuang D.W., Yearout D., Zhang J., Payami H., Zabetian C.P. SNCA variant associated with Parkinson disease and plasma alpha-synuclein level. Arch. Neurol. 2010, 67:1350-1356.
19. Matsumoto L., Takuma H., Tamaoka A., Kurisaki H., Date H., Tsuji S., Iwata A. CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson's disease. PLoS One. 2010, 5:e15522.
20. Miller D.W., Hague S.M., Clarimon J., Baptista M., Gwinn-Hardy K., Cookson M.R., Singleton A.B. Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication. Neurology 2004, 62:1835-1838.
21. Pan-Montojo F., Anichtchik O., Dening Y., Knels L., Pursche S., Jung R., Jackson S., Gille G., Spillantini M.G., Reichmann H., Funk R.H. Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice. PLoS One 2010, 5:e8762.
22. Pezzoli G., Cereda E. Exposure to pesticides or solvents and risk of Parkinson disease. Neurology 2013, 80:2035-2041.
23. Riutta A. Occupational determinants of chlorpyrifos adducts to plasma cholinesterase in chlorpyrifos exposed agricultural workers in Washington State (Master's thesis) 2012, University of Washington, Department of Environmental and Occupational Health Sciences.
24. Shi M., Zabetian C.P., Hancock A.M., Ginghina C., Hong Z., Yearout D., Chung K.A., Quinn J.F., Peskind E.R., Galasko D., Jankovic J., Leverenz J.B., Zhang J. Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease. Neurosci. Lett. 2010, 480:78-82.
25. Shih D.M., Gu L., Xia Y.R., Navab M., Li W.F., Hama S., Castellani L.W., Furlong C.E., Costa L.G., Fogelman A.M., Lusis A.J. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature 1998, 394:284-287.
26. Singleton A.B., Farrer M., Johnson J., Singleton A., Hague S., Kachergus J., Hulihan M., Peuralinna T., Dutra A., Nussbaum R., Lincoln S., Crawley A., Hanson M., Maraganore D., Adler C., Cookson M.R., Muenter M., Baptista M., Miller D., Blancato J., Hardy J., Gwinn-Hardy K. Alpha-synuclein locus triplication causes Parkinson's disease. Science 2003, 302:841.
27. Slotkin T.A., Seidler F.J. Developmental exposure to organophosphates triggers transcriptional changes in genes associated with Parkinson's disease in vitro and in vivo. Brain Res. Bull. 2011, 86:340-347.
28. Spillantini M.G., Schmidt M.L., Lee V.M., Trojanowski J.Q., Jakes R., Goedert M. Alpha-synuclein in Lewy bodies. Nature 1997, 388:839-840.
29. Tanner C.M., Kamel F., Ross G.W., Hoppin J.A., Goldman S.M., Korell M., Marras C., Bhudhikanok G.S., Kasten M., Chade A.R., Comyns K., Richards M.B., Meng C., Priestley B., Fernandez H.H., Cambi F., Umbach D.M., Blair A., Sandler D.P., Langston J.W. Rotenone, paraquat, and Parkinson's disease. Environ. Health Perspect. 2011, 119:866-872.
30. U.S. Department of Agriculture (USDA), 2013. National Agricultural Statistics Service on-line database at: (accessed 25.07.13). http://quickstats.nass.usda.gov/.
31. Washington State Department of Labor and Industries Division of Occupational Safety and Health (WSDOSH), 2007. Cholinesterase Monitoring of Pesticide Handlers in Agriculture: 2007 Final Report. Olympia, Washington.
32. Wilson B.W., Henderson J.D., Furman J.L., Zeller B.E., Michaelsen D. Blood cholinesterases from Washington State orchard workers. Bull. Environ. Contam. Toxicol. 2009, 83:59-61.
33. Wirdefeldt K., Adami H.O., Cole P., Trichopoulos D., Mandel J. Epidemiology and etiology of Parkinson's disease: a review of the evidence. Eur. J. Epidemiol. 2011, 26(Suppl. 1):S1-58.
34. Wirdefeldt K., Gatz M., Reynolds C.A., Prescott C.A., Pedersen N.L. Heritability of Parkinson disease in Swedish twins: a longitudinal study. Neurobiol. Aging 2011, 32(1923):e1-e8.
35. Wright Willis A., Evanoff B.A., Lian M., Criswell S.R., Racette B.A. Geographic and ethnic variation in Parkinson disease: a population-based study of US Medicare beneficiaries. Neuroepidemiology 2010, 34:143-151.