Associations between the GNB3 C825T polymorphism and obesity-related metabolic risk factors in Korean obese women

Academic Psychiatry

Volumn 37, Issue 11, 2014, Pages 1117-1120

  Ko, K D ^a   Kim, K K ^a   Suh, H S ^a   Hwang, I C ^a  

^a Gachon University   (South Korea)

Author keywords

G Protein beta 3 subunit; Metabolic risk factors; Single nucleotide polymorphism

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN (G PROTEIN), BETA POLYPEPTIDE 3, HUMAN; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD PRESSURE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EPIDEMIOLOGY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDY; GENETIC POLYMORPHISM; GENETICS; HUMAN; INSULIN RESISTANCE; METABOLISM; MIDDLE AGED; OBESITY; PHYSIOLOGY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SOUTH KOREA; YOUNG ADULT;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD PRESSURE; DOUBLE-BLIND METHOD; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; INSULIN RESISTANCE; MIDDLE AGED; OBESITY; POLYMORPHISM, GENETIC; REPUBLIC OF KOREA; RISK FACTORS; YOUNG ADULT;

EID: 84910640232     PISSN: 10429670     EISSN: 15457230     Source Type: Journal    
DOI: 10.1007/s40618-014-0182-6     Document Type: Article

References (19)

1. Sims EA (2001) Are there persons who are obese, but metabolically healthy? Metabolism 50:1499-1504
2. Ortega FB, Lee DC, Katzmarzyk PT et al (2013) The intriguing metabolically healthy but obese phenotype: cardiovascular prognosis and role of fitness. Eur Heart J34:389-397
3. Padwal RS, Pajewski NM, Allison DB, Sharma AM (2011) Using the Edmonton obesity staging system to predict mortality in a population-representative cohort of people with overweight and obesity. CMAJ 183:1059-1066
4. Joy T, Lahiry P, Pollex RL, Hegele RA (2008) Genetics of metabolic syndrome. Curr Diab Rep 8:141-148
5. Regard JB, Sato IT, Coughlin SR (2008) Anatomical profiling of G protein-coupled receptor expression. Cell 135:561-571
6. Hsiao TJ, Hwang Y, Liu CH, Chang HM, Lin E (2013) Association of the C825T polymorphism in the GNB3 gene with obesity and metabolic phenotypes in a Taiwanese population. Genes Nutr 8:137-144
7. Wascher TC, Paulweber B, Malaimare L et al (2003) Associations of a human G protein Beta3 subunit dimorphism with insulin resistance and carotid atherosclerosis. Stroke 34:605-609
8. Nürnberger J, Dammer S, Philipp T, Wenzel RR, Schafers RF (2003) Metabolic and haemodynamic effects of oral glucose loading in young healthy men carrying the 825T-allele of the G protein β3 subunit. Cardiovasc Diabetol 2:7
9. Hwang IC, Park JY, Ahn HY et al (2014) Effects of CYP3A5, CYP2C19, and CYP2B6 on the clinical efficacy and adverse outcomes of sibutramine therapy: a crucial role for the CYP2B6 6 allele. Clin Chim Acta 428:77-81
10. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
11. Lee JY, Kim SU, Cho JK, Woo SK, Kang HS (2009) GNB3 C825T polymorphism and elevated blood pressure. Int J Sports Med 30:892-897
12. Arner P (1999) Catecholamine-induced lipolysis in obesity. Int J Obes Relat Metab Disord 23 Suppl 1:10-13
13. Ryden M, Faulds G, Hoffstedt J, Wennlund A, Arner P (2002) Effect of the (C825T) Gbeta(3) polymorphism on adrenoceptor-mediated lipolysis in human fat cells. Diabetes 51:1601-1608
14. Jocken JW, Blaak EE, Schiffelers S (2007) Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation. Int J Obes (Lond) 31:813-819
15. NicholsonAC HajjarDP (1992) Transforming growth factor-beta up-regulates low density lipoprotein receptor-mediated cholesterol metabolism in vascular smooth muscle cells. J Biol Chem 267:25982-25987
16. VijayagopalP SrinivasanSR, RadhakrishnamurthyB Berenson GS (1991) Studies on the mechanism of uptake of low density lipoprotein-proteoglycan complex in macrophages. Biochem Biophys Acta 1092:291-297
17. Ishikawa K, Imai Y, Katsuya T et al (2000) Human G-protein beta3 subunit variant is associated with serum potassium and total cholesterol levels but not with blood pressure. Am J Hypertens 13:140-145
18. Andersen G, Overgaard J, Albrechtsen A et al (2006) Studies of the association of the GNB3 825C > T poly-morphism with components of the metabolic syndrome in white Danes. Diabetologia 49:75-82
19. Stefan N, Stumvoll M, Machicao F et al (2004) C825T polymorphism of the G protein beta3 subunit is associated with obesity but not with insulin sensitivity. Obes Res 12:679-683