Pre-antiretroviral therapy serum selenium concentrations predict WHO stages 3, 4 or death but not virologic failure post-antiretroviral therapy

Nutrients

Volumn 6, Issue 11, 2014, Pages 5061-5078

  Shivakoti, Rupak ^a   Gupte, Nikhil ^a   Yang, Wei Teng ^a   Mwelase, Noluthando ^b   Kanyama, Cecilia ^c   Tang, Alice M ^d   Pillay, Sandy ^e   Samaneka, Wadzanai ^f   Riviere, Cynthia ^g   Berendes, Sima ^h   Lama, Javier R ⁱ   Cardoso, Sandra W ^j   Sugandhavesa, Patcharaphan ^k   Semba, Richard D ^a   Christian, Parul ^l   Campbell Thomas, Thomas B ^m   Gupta, Amita ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^c University of North Carolina Project   (Malawi)

^d TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e DURBAN UNIVERSITY OF TECHNOLOGY   (South Africa)

^f UNIVERSITY OF ZIMBABWE   (Zimbabwe)

^g Department of Adolescent Medicine   (Haïti)

^h LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

ⁱ ASOCIACIÓN CIVIL IMPACTA SALUD Y EDUCACIÓN   (Peru)

^j Funda??o Oswaldo Cruz   (Brazil)

^k Research Institute for Health Sciences   (Thailand)

^l JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^m UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

more..

Author keywords

Antiretroviral therapy; Cohort studies; HIV; Nutrition; Selenium; Treatment failure

Indexed keywords

ATAZANAVIR; C REACTIVE PROTEIN; DIDANOSINE; EFAVIRENZ PLUS EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; EFAVIRENZ PLUS LAMIVUDINE PLUS ZIDOVUDINE; EMTRICITABINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZOXAZINE DERIVATIVE; DEOXYCYTIDINE; EFAVIRENZ; LAMIVUDINE; OLIGOPEPTIDE; PYRIDINE DERIVATIVE; SELENIUM; ZIDOVUDINE;

ADULT; ANEMIA; ANTIRETROVIRAL THERAPY; ANTIVIRAL THERAPY; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BODY MASS; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HAZARD RATIO; HIV RAPID TEST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MAJOR CLINICAL STUDY; MALE; NUTRITION; RISK FACTOR; SELENIUM BLOOD LEVEL; SELENIUM DEFICIENCY; TREATMENT FAILURE; TREATMENT OUTCOME; TUBERCULOSIS; VIRUS LOAD; ANALOGS AND DERIVATIVES; BLOOD; CLINICAL TRIAL; DEFICIENCY; HIV INFECTIONS; METABOLISM; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; STATISTICAL MODEL; WORLD HEALTH ORGANIZATION;

ADULT; ANTI-HIV AGENTS; ATAZANAVIR SULFATE; BENZOXAZINES; BODY MASS INDEX; C-REACTIVE PROTEIN; CD4 LYMPHOCYTE COUNT; DEOXYCYTIDINE; DIDANOSINE; DISEASE PROGRESSION; EMTRICITABINE; FEMALE; HIV INFECTIONS; HUMANS; LAMIVUDINE; LOGISTIC MODELS; MALE; MULTIVARIATE ANALYSIS; OLIGOPEPTIDES; PROSPECTIVE STUDIES; PYRIDINES; RISK FACTORS; SELENIUM; WORLD HEALTH ORGANIZATION; ZIDOVUDINE;

EID: 84910638040     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu6115061     Document Type: Article

References (56)

1. The Joint United Nations Programme on HIV/AIDS (UNAIDS). Global Report: Unaids Report on the Global Aids Epidemic; Joint United Nations Programme on HIV/AIDS: Geneva, Switzerland, 2013.
2. Moh, R.; Danel, C.; Messou, E.; Ouassa, T.; Gabillard, D.; Anzian, A.; Abo, Y.; Salamon, R.; Bissagnene, E.; Seyler, C., et al. Incidence and determinants of mortality and morbidity following early antiretroviral therapy initiation in HIV-infected adults in West Africa. AIDS 2007, 21, 2483-2491.
3. Moore, D.; Liechty, C.; Ekwaru, P.; Were, W.; Mwima, G.; Solberg, P.; Rutherford, G.; Mermin, J. Prevalence, incidence and mortality associated with tuberculosis in HIV-infected patients initiating antiretroviral therapy in rural Uganda. AIDS 2007, 21, 713-719.
4. Paton, N.I.; Sangeetha, S.; Earnest, A.; Bellamy, R. The impact of malnutrition on survival and the CD4 count response in HIV-infected patients starting antiretroviral therapy. HIV Med. 2006, 7, 323-330.
5. Irlam, J.H.; Visser, M.M.; Rollins, N.N.; Siegfried, N. Micronutrient supplementation in children and adults with HIV infection. Cochrane Database Syst. Rev. 2010, 10, doi:10.1002/14651858.CD003650.
6. Stone, C.A.; Kawai, K.; Kupka, R.; Fawzi, W.W. Role of selenium in HIV infection. Nutr. Rev. 2010, 68, 671-681.
7. Kupka, R.; Mugusi, F.; Aboud, S.; Msamanga, G.I.; Finkelstein, J.L.; Spiegelman, D.; Fawzi, W.W. Randomized, double-blind, placebo-controlled trial of selenium supplements among HIV-infected pregnant women in Tanzania: Effects on maternal and child outcomes. Am. J. Clin. Nutr. 2008, 87, 1802-1808.
8. Hurwitz, B.E.; Klaus, J.R.; Llabre, M.M.; Gonzalez, A.; Lawrence, P.J.; Maher, K.J.; Greeson, J.M.; Baum, M.K.; Shor-Posner, G.; Skyler, J.S., et al. Suppression of human immunodeficiency virus type 1 viral load with selenium supplementation: A randomized controlled trial. Arch. Intern. Med. 2007, 167, 148-154.
9. Burbano, X.; Miguez-Burbano, M.J.; McCollister, K.; Zhang, G.; Rodriguez, A.; Ruiz, P.; Lecusay, R.; Shor-Posner, G. Impact of a selenium chemoprevention clinical trial on hospital admissions of HIV-infected participants. HIV Clin. Trials 2002, 3, 483-491.
10. Baum, M.K.; Campa, A.; Lai, S.; Martinez, S.S.; Tsalaile, L.; Burns, P.; Farahani, M.; Li, Y.; van Widenfelt, E.; Page, J.B., et al. Effect of micronutrient supplementation on disease progression in asymptomatic, antiretroviral-naive, HIV-infected adults in Botswana: A randomized clinical trial. JAMA 2013, 310, 2154-2163.
11. Rayman, M.P. Selenium and human health. Lancet 2012, 379, 1256-1268.
12. Schmidt, R.L.; Simonovic, M. Synthesis and decoding of selenocysteine and human health. Croat. Med. J. 2012, 53, 535-550.
13. Reeves, M.A.; Hoffmann, P.R. The human selenoproteome: Recent insights into functions and regulation. Cell. Mol. Life Sci. CMLS 2009, 66, 2457-2478.
14. Blas-Garcia, A.; Apostolova, N.; Esplugues, J.V. Oxidative stress and mitochondrial impairment after treatment with anti-HIV drugs: Clinical implications. Curr. Pharm. Des. 2011, 17, 4076-4086.
15. Sappey, C.; Legrand-Poels, S.; Best-Belpomme, M.; Favier, A.; Rentier, B.; Piette, J. Stimulation of glutathione peroxidase activity decreases HIV type 1 activation after oxidative stress. AIDS Res. Hum. Retrovir. 1994, 10, 1451-1461.
16. Kalantari, P.; Narayan, V.; Natarajan, S.K.; Muralidhar, K.; Gandhi, U.H.; Vunta, H.; Henderson, A.J.; Prabhu, K.S. Thioredoxin reductase-1 negatively regulates HIV-1 transactivating protein tat-dependent transcription in human macrophages. J. Biol. Chem. 2008, 283, 33183-33190.
17. Rayman, M.P. Food-chain selenium and human health: Emphasis on intake. Br. J. Nutr. 2008, 100, 254-268.
18. Duntas, L.H. Selenium and inflammation: Underlying anti-inflammatory mechanisms. Horm. Metab. Res. 2009, 41, 443-447.
19. Drain, P.K.; Baeten, J.M.; Overbaugh, J.; Wener, M.H.; Bankson, D.D.; Lavreys, L.; Mandaliya, K.; Ndinya-Achola, J.O.; McClelland, R.S. Low serum albumin and the acute phase response predict low serum selenium in HIV-1 infected women. BMC Infect. Dis. 2006, 6, doi:10.1186/1471-2334-6-85.
20. Campbell, T.B.; Smeaton, L.M.; Kumarasamy, N.; Flanigan, T.; Klingman, K.L.; Firnhaber, C.; Grinsztejn, B.; Hosseinipour, M.C.; Kumwenda, J.; Lalloo, U., et al. Efficacy and safety of three antiretroviral regimens for initial treatment of HIV-1: A randomized clinical trial in diverse multinational settings. PLoS Med. 2012, 9, doi:10.1371/journal.pmed.100129.
21. Barlow, W.E.; Ichikawa, L.; Rosner, D.; Izumi, S. Analysis of case-cohort designs. J. Clin. Epidemiol. 1999, 52, 1165-1172.
22. Onland-Moret, N.C.; van der, A.D.L.; van der Schouw, Y.T.; Buschers, W.; Elias, S.G.; van Gils, C.H.; Koerselman, J.; Roest, M.; Grobbee, D.E.; Peeters, P.H. Analysis of case-cohort data: A comparison of different methods. J. Clin. Epidemiol. 2007, 60, 350-355.
23. Campa, A.; Shor-Posner, G.; Indacochea, F.; Zhang, G.; Lai, H.; Asthana, D.; Scott, G.B.; Baum, M.K. Mortality risk in selenium-deficient HIV-positive children. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1999, 20, 508-513.
24. Baum, M.K.; Shor-Posner, G.; Lai, S.; Zhang, G.; Lai, H.; Fletcher, M.A.; Sauberlich, H.; Page, J.B. High risk of HIV-related mortality is associated with selenium deficiency. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1997, 15, 370-374.
25. Baeten, J.M.; Mostad, S.B.; Hughes, M.P.; Overbaugh, J.; Bankson, D.D.; Mandaliya, K.; Ndinya-Achola, J.O.; Bwayo, J.J.; Kreiss, J.K. Selenium deficiency is associated with shedding of HIV-1—Infected cells in the female genital tract. J. Acquir. Immune Defic. Syndr. 2001, 26, 360-364.
26. Maehira, F.; Luyo, G.A.; Miyagi, I.; Oshiro, M.; Yamane, N.; Kuba, M.; Nakazato, Y. Alterations of serum selenium concentrations in the acute phase of pathological conditions. Clin. Chim. Acta 2002, 316, 137-146.
27. Fairweather-Tait, S.J.; Bao, Y.; Broadley, M.R.; Collings, R.; Ford, D.; Hesketh, J.E.; Hurst, R. Selenium in human health and disease. Antioxid. Redox Signal. 2011, 14, 1337-1383.
28. Semba, R.D.; Ricks, M.O.; Ferrucci, L.; Xue, Q.L.; Guralnik, J.M.; Fried, L.P. Low serum selenium is associated with anemia among older adults in the United States. Eur. J. Clin. Nutr. 2009, 63, 93-99.
29. Nichol, C.; Herdman, J.; Sattar, N.; O’Dwyer, P.J.; O’Reilly, D.S.J.; Littlejohn, D.; Fell, G. Changes in the concentrations of plasma selenium and selenoproteins after minor elective surgery: Further evidence for a negative acute phase response? Clin. Chem. 1998, 44, 1764-1766.
30. Ford, E.S.; Liu, S.; Mannino, D.M.; Giles, W.H.; Smith, S.J. C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults. Eur. J. Clin. Nutr. 2003, 57, 1157-1163.
31. Drain, P.K.; Kupka, R.; Msamanga, G.I.; Urassa, W.; Mugusi, F.; Fawzi, W.W. C-reactive protein independently predicts HIV-related outcomes among women and children in a resource-poor setting. AIDS 2007, 21, 2067-2075.
32. Van Lettow, M.; West, C.E.; van der Meer, J.W.; Wieringa, F.T.; Semba, R.D. Low plasma selenium concentrations, high plasma human immunodeficiency virus load and high interleukin-6 concentrations are risk factors associated with anemia in adults presenting with pulmonary tuberculosis in Zomba district, Malawi. Eur. J. Clin. Nutr. 2005, 59, 526-532.
33. Sheehan, H.B.; Benetucci, J.; Muzzio, E.; Redini, L.; Naveira, J.; Segura, M.; Weissenbacher, M.; Tang, A.M. High rates of serum selenium deficiency among HIV-and HCV-infected and uninfected drug users in Buenos Aires, Argentina. Public Health Nutr. 2012, 15, 538-545.
34. Look, M.P.; Rockstroh, J.K.; Rao, G.S.; Kreuzer, K.A.; Barton, S.; Lemoch, H.; Sudhop, T.; Hoch, J.; Stockinger, K.; Spengler, U., et al. Serum selenium, plasma glutathione (GSH) and erythrocyte glutathione peroxidase (GSH-Px)-levels in asymptomatic versus symptomatic human immunodeficiency virus-1 (HIV-1)-infection. Eur. J. Clin. Nutr. 1997, 51, 266-272.
35. Kupka, R.; Msamanga, G.I.; Spiegelman, D.; Rifai, N.; Hunter, D.J.; Fawzi, W.W. Selenium levels in relation to morbidity and mortality among children born to HIV-infected mothers. Eur. J. Clin. Nutr. 2005, 59, 1250-1258.
36. Kupka, R.; Msamanga, G.I.; Spiegelman, D.; Morris, S.; Mugusi, F.; Hunter, D.J.; Fawzi, W.W. Selenium status is associated with accelerated HIV disease progression among HIV-1-infected pregnant women in Tanzania. J. Nutr. 2004, 134, 2556-2560.
37. Kupka, R.; Garland, M.; Msamanga, G.; Spiegelman, D.; Hunter, D.; Fawzi, W. Selenium status, pregnancy outcomes, and mother-to-child transmission of HIV-1. J. Acquir. Immune Defic. Syndr. 2005, 39, 203-210.
38. Shor-Posner, G.; Miguez, M.J.; Pineda, L.M.; Rodriguez, A.; Ruiz, P.; Castillo, G.; Burbano, X.; Lecusay, R.; Baum, M. Impact of selenium status on the pathogenesis of mycobacterial disease in HIV-1-infected drug users during the era of highly active antiretroviral therapy. J. Acquir. Immune Defic. Syndr. 2002, 29, 169-173.
39. Constans, J.; Pellegrin, J.L.; Sergeant, C.; Simonoff, M.; Pellegrin, I.; Fleury, H.; Leng, B.; Conri, C. Serum selenium predicts outcome in HIV infection. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1995, 10, 392.
40. Stephensen, C.B.; Marquis, G.S.; Douglas, S.D.; Wilson, C.M. Immune activation and oxidative damage in HIV-positive and HIV-negative adolescents. J. Acquir. Immune Defic. Syndr. 2005, 38, 180-190.
41. Stephensen, C.B.; Marquis, G.S.; Douglas, S.D.; Kruzich, L.A.; Wilson, C.M. Glutathione, glutathione peroxidase, and selenium status in HIV-positive and HIV-negative adolescents and young adults. Am. J. Clin. Nutr. 2007, 85, 173-181.
42. Stambullian, M.; Feliu, S.; Slobodianik, N.H. Nutritional status in patients with HIV infection and aids. Br. J. Nutr. 2007, 98, 140-143.
43. Rousseau, M.C.; Molines, C.; Moreau, J.; Delmont, J. Influence of highly active antiretroviral therapy on micronutrient profiles in HIV-infected patients. Ann. Nutr. Metab. 2000, 44, 212-216.
44. Look, M.P.; Rockstroh, J.K.; Rao, G.S.; Kreuzer, K.A.; Spengler, U.; Sauerbruch, T. Serum selenium vs lymphocyte subsets and markers of disease progression and inflammatory response in human immunodeficiency virus-1 infection. Biol. Trace Elem. Res. 1997, 56, 31-41.
45. Jones, C.Y.; Tang, A.M.; Forrester, J.E.; Huang, J.; Hendricks, K.M.; Knox, T.A.; Spiegelman, D.; Semba, R.D.; Woods, M.N. Micronutrient levels and HIV disease status in HIV-infected patients on highly active antiretroviral therapy in the nutrition for healthy living cohort. J. Acquir. Immune Defic. Syndr. 2006, 43, 475-482.
46. Baum, M.K.; Shor-Posner, G.; Zhang, G.; Lai, H.; Quesada, J.A.; Campa, A.; Jose-Burbano, M.; Fletcher, M.A.; Sauberlich, H.; Page, J.B. HIV-1 infection in women is associated with severe nutritional deficiencies. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1997, 16, 272-278.
47. Shenkin, A. Micronutrients in health and disease. Postgrad. Med. J. 2006, 82, 559-567.
48. Nathan, C.; Cunningham-Bussel, A. Beyond oxidative stress: An immunologist’s guide to reactive oxygen species. Nat. Rev. Immunol. 2013, 13, 349-361.
49. Kohen, R.; Nyska, A. Oxidation of biological systems: Oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicol. Pathol. 2002, 30, 620-650.
50. Duffield, A.J.; Thomson, C.D.; Hill, K.E.; Williams, S. An estimation of selenium requirements for new zealanders. Am. J. Clin. Nutr. 1999, 70, 896-903.
51. Thomson, C.D.; Robinson, M.F.; Butler, J.A.; Whanger, P.D. Long-term supplementation with selenate and selenomethionine: Selenium and glutathione peroxidase (ec 1.11.1.9) in blood components of New Zealand women. Br. J. Nutr. 1993, 69, 577-588.
52. Bunupuradah, T.; Ubolyam, S.; Hansudewechakul, R.; Kosalaraksa, P.; Ngampiyaskul, C.; Kanjanavanit, S.; Wongsawat, J.; Luesomboon, W.; Pinyakorn, S.; Kerr, S., et al. Correlation of selenium and zinc levels to antiretroviral treatment outcomes in Thai HIV-infected children without severe HIV symptoms. Eur. J. Clin. Nutr. 2012, 66, 900-905.
53. Dillon, D.M.; Stapleton, J.T. Selenium effects on HIV rna and CD4 cell counts. Arch. Intern. Med. 2007, 167, 1556-1557.
54. Ross, D.A.; Cousens, S.; Wedner, S.H.; Sismanidis, C. Does selenium supplementation slow progression of HIV? Potentially misleading presentation of the results of a trial. Arch. Intern. Med. 2007, 167, 1555-1556.
55. Passaretti, C.; Gupta, A. Selenium and HIV-1: Hope or hype? Arch. Intern. Med. 2007, 167, 2530-2531.
56. Safren, S.A.; Biello, K.B.; Smeaton, L.; Mimiaga, M.J.; Walawander, A.; Lama, J.R.; Rana, A.; Nyirenda, M.; Kayoyo, V.M.; Samaneka, W., et al. Psychosocial predictors of non-adherence and treatment failure in a large scale multi-national trial of antiretroviral therapy for HIV: Data from the actg a5175/pearls trial. PLoS One 2014, 9, doi:10.1371/journal.pone.0104178.