Binding to Cep164, but not EB1, is essential for centriolar localization of TTBK2 and its function in ciliogenesis

Genes to Cells

Volumn 19, Issue 12, 2014, Pages 927-940

  Oda, Toshiaki ^a   Chiba, Shuhei ^a   Nagai, Tomoaki ^a   Mizuno, Kensaku ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CEP164 PROTEIN, HUMAN; DISHEVELLED PROTEINS; MAPRE1 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE PROTEIN; PHOSPHOPROTEIN; PROTEIN SERINE THREONINE KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TAU-TUBULIN KINASE;

ANIMAL; CELL DIFFERENTIATION; CELL LINE; CENTRIOLE; CYTOLOGY; EUKARYOTIC FLAGELLUM; HUMAN; KIDNEY COLLECTING TUBULE; METABOLISM; MOUSE; MUTATION; PHOSPHORYLATION; PROTEIN DOMAIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL DIFFERENTIATION; CELL LINE; CENTRIOLES; CILIA; HUMANS; KIDNEY TUBULES, COLLECTING; MICE; MICROTUBULE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN-SERINE-THREONINE KINASES;

EID: 84910609470     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/gtc.12191     Document Type: Article

References (31)

1. Bettencourt-Dias, M. & Carvalho-Santos, Z. (2008) Double life of centrioles: CP110 in the spotlight. Trends Cell Biol. 18, 8-11.
2. Bouskila, M., Esoof, N., Gay, L., Fang, E.H., Deak, M., Begley, M.J., Cantley, L.C., Prescott, A., Storey, K.G. & Alessi, D.R. (2011) TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. Biochem. J. 437, 157-167.
3. Čajánek, L. & Nigg, E.A. (2014) Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole. Proc. Natl Acad. Sci. USA 111, E2841-E2850.
4. Chaki, M., Airik, R., Ghosh, A.K. et al. (2012) Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell 150, 533-548.
5. Chiba, S., Amagai, Y., Homma, Y., Fukuda, M. & Mizuno, K. (2013) NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15. EMBO J. 32, 874-885.
6. Fliegauf, M., Benzing, T. & Omran, H. (2007) When cilia go bad: cilia defects and ciliopathies. Nat. Rev. Mol. Cell Biol. 8, 880-893.
7. Gao, C. & Chen, Y.G. (2010) Dishevelled: the hub of Wnt signaling. Cell. Signal. 22, 717-727.
8. Gerdes, J.M., Davis, E.E. & Katsanis, N. (2009) The vertebrate primary cilium in development, homeostasis, and disease. Cell 137, 32-45.
9. Goetz, S.C. & Anderson, K.V. (2010) The primary cilium: a signalling centre during vertebrate development. Nat. Rev. Genet. 11, 331-344.
10. Goetz, S.C., Liem, K.F. & Anderson, K.V. (2012) The spinocerebellar ataxia-associated gene tau tubulin kinase 2 controls the initiation of ciliogenesis. Cell 151, 847-858.
11. Graser, S., Stierhof, Y.D., Lavoie, S.B., Gassner, O.S., Lamla, S., Le Clech, M. & Nigg, E.A. (2007) Cep164, a novel centriole appendage protein required for primary cilium formation. J. Cell Biol. 179, 321-330.
12. Honnappa, S., Gouveia, S.M., Weisbrich, A., Damberger, F.F., Bhavesh, N.S., Jawhari, H., Grigoriev, I., van Rijssel, F.J.A., Buey, R.M., Lawera, A., Jelesarov, I., Winkler, F.K., Wuthrich, K., Akhmanova, A. & Steinmetz, M.O. (2009) An EB1-binding motif acts as a microtubule tip localization signal. Cell 138, 366-376.
13. Houlden, H., Johnson, J., Gardner-Thorpe, C., Lashley, T., Hernandez, D., Worth, P., Singleton, A.B., Hilton, D.A., Holton, J., Revesz, T., Davis, M.B., Giunti, P. & Wood, N.W. (2007) Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11. Nat. Genet. 39, 1434-1436.
14. Ilsley, J.L., Sudol, M. & Winder, S.J. (2002) The WW domain: linking cell signalling to the membrane cytoskeleton. Cell. Signal. 14, 183-189.
15. Jiang, K., Toedt, G., Gouveia, S.M., Davey, N.E., Hua, S.S., van der Vaart, B., Grigoriev, I., Larsen, J., Pedersen, L.B., Bezstarosti, K., Lince-Faria, M., Demmers, J., Steinmetz, M.O., Gibson, T.J. & Akhmanova, A. (2012) A proteome-wide screen for mammalian SxIP motif-containing microtubule plus-end tracking proteins. Curr. Biol. 22, 1800-1807.
16. Joo, K., Kim, C.G., Lee, M.S., Moon, H.Y., Lee, S.H., Kim, M.J., Kweon, H.S., Park, W.Y., Kim, C.H., Gleeson, J.G. & Kim, J. (2013) CCDC41 is required for ciliary vesicle docking to the mother centriole. Proc. Natl Acad. Sci. USA 110, 5987-5992.
17. Kobayashi, T. & Dynlacht, B.D. (2011) Regulating the transition from centriole to basal body. J. Cell Biol. 193, 435-444.
18. Lee, K.H., Johmura, Y., Yu, L.R., Park, J.E., Gao, Y., Bang, J.K., Zhou, M., Veenstra, T.D., Kim, B.Y. & Lee, K.S. (2012) Identification of a novel Wnt5a-CK1ε-Dvl2-Plk1-mediated primary cilia disassembly pathway. EMBO J. 31, 3104-3117.
19. Marshall, W.F. (2008) The cell biological basis of ciliary disease. J. Cell Biol. 180, 17-21.
20. Nagai, T., Ikeda, M., Chiba, S., Kanno, S. & Mizuno, K. (2013) Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase. J. Cell Sci. 126, 4369-4380.
21. Park, T.J., Mitchell, B.J., Abitua, P.B., Kintner, C. & Wallingford, J.B. (2008) Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells. Nat. Genet. 40, 871-879.
22. Schmidt, K.N., Kuhns, S., Neuner, A., Hub, B., Zentgraf, H. & Pereira, G. (2012) Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis. J. Cell Biol. 199, 1083-1101.
23. Schroder, J.M., Larsen, J., Komarova, Y., Akhmanova, A., Thorsteinsson, R.I., Grigoriev, I., Manguso, R., Christensen, S.T., Pedersen, S.F., Geimer, S. & Pedersen, L.B. (2011) EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanisms. J. Cell Sci. 124, 2539-2551.
24. Schroder, J.M., Schneider, L., Christensen, S.T. & Pedersen, L.B. (2007) EB1 is required for primary cilia assembly in fibroblasts. Curr. Biol. 17, 1134-1139.
25. Sivasubramaniam, S., Sun, X.M., Pan, Y.R., Wang, S.H. & Lee, E. (2008) Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1. Genes Dev. 22, 587-600.
26. Slep, K.C. (2010) Structural and mechanistic insights into microtubule end-binding proteins. Curr. Opin. Cell Biol. 22, 88-95.
27. Spektor, A., Tsang, W.Y., Khoo, D. & Dynlacht, B.D. (2007) Cep97 and CP110 suppress a cilia assembly program. Cell 130, 678-690.
28. Takahashi, M., Tomizawa, K., Sato, K., Ohtake, A. & Omori, A. (1995) A novel Tau-tubulin kinase from bovine brain. FEBS Lett. 372, 59-64.
29. Tanos, B.E., Yang, H.J., Soni, R., Wang, W.J., Macaluso, F.P., Asara, J.M. & Tsou, M.F.B. (2013) Centriole distal appendages promote membrane docking, leading to cilia initiation. Genes Dev. 27, 163-168.
30. Tsang, W.Y. & Dynlacht, B.D. (2013) CP110 and its network of partners coordinately regulate cilia assembly. Cilia 2, 9.
31. Ye, X., Zeng, H.Q., Ning, G., Reiter, J.F. & Liu, A.M. (2014) C2 cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals. Proc. Natl Acad. Sci. USA 111, 2164-2169.