Gcn 5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1

EMBO Reports

Volumn 15, Issue 11, 2014, Pages 1192-1201

  Jin, Qihuang ^a,b   Zhuang, Lenan ^a   Lai, Binbin ^a   Wang, Chaochen ^a   Li, Wenqian ^b   Dolan, Brian ^c   Lu, Yue ^b   Wang, Zhibin ^d   Zhao, Keji ^d   Peng, Weiqun ^e   Dent, Sharon Y R ^b   Ge, Kai ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

Gcn5 PCAF; H3K9ac; Innate immune signaling; Interferon ; TBK1

Indexed keywords

BETA INTERFERON; HISTONE ACETYLTRANSFERASE GCN5; HISTONE ACETYLTRANSFERASE PCAF; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 7; INTERFERON REGULATORY FACTOR 9; INTERFERON STIMULATED GENE FACTOR 3; MESSENGER RNA; PHOSPHOTRANSFERASE; RETINOIC ACID INDUCIBLE PROTEIN I; STAT1 PROTEIN; STAT2 PROTEIN; TANK BINDING KINASE 1; TOLL LIKE RECEPTOR 3; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; UNCLASSIFIED DRUG; HISTONE; P300-CBP-ASSOCIATED FACTOR; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; TBK1 PROTEIN, HUMAN;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPATHOGENIC EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROBLAST; GENE ACTIVATION; GENE DELETION; GENE EXPRESSION; HOST RESISTANCE; HUMAN; HUMAN CELL; INNATE IMMUNITY; LIMIT OF DETECTION; LUCIFERASE ASSAY; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEOTIDE SEQUENCE; PROADIPOCYTE; SEQUENCE HOMOLOGY; TRANSCRIPTION INITIATION SITE; UPREGULATION; VESICULAR STOMATITIS VIRUS; VIRUS IMMUNITY; ACETYLATION; GENETICS; HEK293 CELL LINE; IMMUNOLOGY; METABOLISM;

ACETYLATION; FIBROBLASTS; HEK293 CELLS; HISTONES; HUMANS; IMMUNITY, INNATE; INTERFERON-BETA; P300-CBP TRANSCRIPTION FACTORS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES;

EID: 84910131191     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201438990     Document Type: Article

References (24)

1. Honda K, Takaoka A, Taniguchi T (2006) Type I interferon gene induction by the interferon regulatory factor family of transcription factors. Immunity 25: 349-360
2. Hiscott J (2007) Triggering the innate antiviral response through IRF-3 activation. J Biol Chem 282: 15325-15329
3. Kishore N, Huynh QK, Mathialagan S, Hall T, Rouw S, Creely D, Lange G, Caroll J, Reitz B, Donnelly A et al (2002) IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2. J Biol Chem 277: 13840-13847
4. Lei CQ, Zhong B, Zhang Y, Zhang J, Wang S, Shu HB (2010) Glycogen synthase kinase 3beta regulates IRF 3 transcription factor-mediated antiviral response via activation of the kinase TBK1. Immunity 33: 878-889
5. Agalioti T, Chen G, Thanos D (2002) Deciphering the transcriptional histone acetylation code for a human gene. Cell 111: 381
6. Conacci-Sorrell M, Ngouenet C, Eisenman RN (2010) Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation. Cell 142: 480-493
7. Nagy Z, Tora L (2007) Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation. Oncogene 26: 5341-5357
8. Jin Q, Yu LR, Wang L, Zhang Z, Kasper LH, Lee JE, Wang C, Brindle PK, Dent SY, Ge K et al (2011) Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p 300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J 30: 249-262
9. Wang Z, Zang C, Rosenfeld JA, Schones DE, Barski A, Cuddapah S, Cui K, Roh TY, Peng W, Zhang MQ et al (2008) Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet 40: 897-903
10. Loven J, Orlando DA, Sigova AA, Lin CY, Rahl PB, Burge CB, Levens DL, Lee TI, Young RA (2012) Revisiting global gene expression analysis. Cell 151: 476-482
11. Raj NB, Pitha PM (1981) Analysis of interferon mRNA in human fibroblast cells induced to produce interferon. Proc Natl Acad Sci USA 78: 7426-7430
12. Bu P, Evrard YA, Lozano G, Dent SY (2007) Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos. Mol Cell Biol 27: 3405-3416
13. Lin R, Heylbroeck C, Pitha PM, Hiscott J (1998) Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol Cell Biol 18: 2986-2996
14. Clark K, Plater L, Peggie M, Cohen P (2009) Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation. J Biol Chem 284: 14136-14146
15. tenOever BR, Sharma S, Zou W, Sun Q, Grandvaux N, Julkunen I, Hemmi H, Yamamoto M, Akira S, Yeh WC et al (2004) Activation of TBK1 and IKKe kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. J Virol 78: 10636-10649
16. Ou YH, Torres M, Ram R, Formstecher E, Roland C, Cheng T, Brekken R, Wurz R, Tasker A, Polverino T et al (2011) TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation. Mol Cell 41: 458-470
17. Santos-Rosa H, Valls E, Kouzarides T, Martínez-Balbás M (2003) Mechanisms of P/CAF auto-acetylation. Nucleic Acids Res 31: 4285-4292
18. Atanassov BS, Evrard YA, Multani AS, Zhang Z, Tora L, Devys D, Chang S, Dent SY (2009) Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. Mol Cell 35: 352-364
19. Mao X, Gluck N, Li D, Maine GN, Li H, Zaidi IW, Repaka A, Mayo MW, Burstein E (2009) GCN5 is a required cofactor for a ubiquitin ligase that targets NF-κB/RelA. Genes Dev 23: 849-861
20. Sun L, Liu S, Chen ZJ (2010) SnapShot: pathways of antiviral innate immunity. Cell 140: 436-436e432
21. Banchereau J, Pascual V (2006) Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 25: 383-392
22. Lee JE, Wang C, Xu S, Cho YW, Wang L, Feng X, Baldridge A, Sartorelli V, Zhuang L, Peng W et al (2013) H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation. eLife 2: e01503
23. Zang C, Schones DE, Zeng C, Cui K, Zhao K, Peng W (2009) A clustering approach for identification of enriched domains from histone modification ChIP-Seq data. Bioinformatics 25: 1952-1958
24. Lee FS, Peters RT, Dang LC, Maniatis T (1998) MEKK1 activates both I-kappaB kinase alpha and IkappaB kinase beta. Proc Natl Acad Sci USA 95: 9319-9324