Concentration-dependent biphasic effects of resveratrol on human natural killer cells in vitro

Journal of Agricultural and Food Chemistry

Volumn 62, Issue 45, 2014, Pages 10928-10935

  Li, Qi ^a   Huyan, Ting ^a   Ye, Lin Jie ^a   Li, Ji ^a   Shi, Jun Ling ^a   Huang, Qing Sheng ^a  

^a NORTHWESTERN POLYTECHNICAL UNIVERSITY   (China)

Author keywords

apoptosis; caspase; cytotoxicity; human natural killer (NK) cells; resveratrol (RES)

Indexed keywords

CELL DEATH; CELLS; CYTOLOGY; CYTOTOXICITY; DRUG DOSAGE; RESVERATROL;

ANTITUMOR DRUGS; BIOLOGICAL EFFECTS; BIPHASIC EFFECTS; CASPASES; CONCENTRATION RANGES; CONCENTRATION-DEPENDENT; NATURAL KILLER CELLS; SIGNALING PATHWAYS;

CELL SIGNALING;

RESVERATROL; STILBENE DERIVATIVE;

APOPTOSIS; CYTOLOGY; DRUG EFFECTS; HUMAN; IMMUNOLOGY; JURKAT CELL LINE; NATURAL KILLER CELL; SIGNAL TRANSDUCTION;

APOPTOSIS; HUMANS; JURKAT CELLS; KILLER CELLS, NATURAL; SIGNAL TRANSDUCTION; STILBENES;

EID: 84910115953     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf502950u     Document Type: Article

References (43)

1. Dudka, J.; Gieroba, R.; Korga, A.; Burdan, F.; Matysiak, W.; Jodlowska-Jedrych, B.; Mandziuk, S.; Korobowicz, E.; Murias, M. Different effects of resveratrol on dose-related Doxorubicin-induced heart and liver toxicity Evidence-Based Complementary Altern. Med.: eCAM 2012, 2012, 606183
2. Sadruddin, S.; Arora, R. Resveratrol: Biologic and therapeutic implications J. CardioMetab. Syndr. 2009, 4, 102-6
3. Tome-Carneiro, J.; Larrosa, M.; Gonzalez-Sarrias, A.; Tomas-Barberan, F. A.; Garcia-Conesa, M. T.; Espin, J. C. Resveratrol and clinical trials: The crossroad from in vitro studies to human evidence Curr. Pharm. Des. 2013, 19, 6064-93
4. Pangeni, R.; Sahni, J. K.; Ali, J.; Sharma, S.; Baboota, S. Resveratrol: Review on therapeutic potential and recent advances in drug delivery Expert Opin. Drug Deliv. 2014, 11, 1285-98
5. Liu, Y. Z.; Wu, K.; Huang, J.; Liu, Y.; Wang, X.; Meng, Z. J.; Yuan, S. X.; Wang, D. X.; Luo, J. Y.; Zuo, G. W.; Yin, L. J.; Chen, L.; Deng, Z. L.; Yang, J. Q.; Sun, W. J.; He, B. C. The PTEN/PI3K/Akt and Wnt/beta-catenin signaling pathways are involved in the inhibitory effect of resveratrol on human colon cancer cell proliferation Int. J. Oncol. 2014, 45, 104-12
6. Ferruelo, A.; Romero, I.; Cabrera, P. M.; Arance, I.; Andres, G.; Angulo, J. C. Effects of resveratrol and other wine polyphenols on the proliferation, apoptosis and androgen receptor expression in LNCaP cells Actas Urol. Esp. 2014, 38, 397-404
7. Frazzi, R.; Tigano, M. The multiple mechanisms of cell death triggered by resveratrol in lymphoma and leukemia Int. J. Mol. Sci. 2014, 15, 4977-93
8. Cooper, M. A.; Fehniger, T. A.; Caligiuri, M. A. The biology of human natural killer-cell subsets Trends Immunol. 2001, 22, 633-40
9. Trinchieri, G. Biology of natural killer cells Adv. Immunol. 1989, 47, 187-376
10. Huang, Q. S.; Li, Q.; Huang, Y.; Shang, P.; Zhang, M. J. Expansion of human natural killer cells ex vivo Xibao yu Fenzi Mianyixue Zazhi 2008, 24, 1167-9
11. Imai, C.; Iwamoto, S.; Campana, D. Genetic modification of primary natural killer cells overcomes inhibitory signals and induces specific killing of leukemic cells Blood 2005, 106, 376-83
12. Li, Q.; Mei, Q.; Huyan, T.; Xie, L.; Che, S.; Yang, H.; Zhang, M.; Huang, Q. Effects of simulated microgravity on primary human NK cells Astrobiology 2013, 13, 703-14
13. Chen, Y.; Wang, Y.; Zhuang, Y.; Zhou, F.; Huang, L. Mifepristone increases the cytotoxicity of uterine natural killer cells by acting as a glucocorticoid antagonist via ERK activation PloS One 2012, 7, e36413
14. Livak, K. J.; Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods 2001, 25, 402-8
15. Denman, C. J.; Senyukov, V. V.; Somanchi, S. S.; Phatarpekar, P. V.; Kopp, L. M.; Johnson, J. L.; Singh, H.; Hurton, L.; Maiti, S. N.; Huls, M. H.; Champlin, R. E.; Cooper, L. J.; Lee, D. A. Membrane-bound IL-21 promotes sustained ex vivo proliferation of human natural killer cells PloS One 2012, 7, e30264
16. Baur, J. A.; Sinclair, D. A. Therapeutic potential of resveratrol: the in vivo evidence Nat. Rev. Drug Discov. 2006, 5, 493-506
17. Pezzuto, J. M. The phenomenon of resveratrol: Redefining the virtues of promiscuity Ann. N.Y. Acad. Sci. 2011, 1215, 123-30
18. Howitz, K. T.; Bitterman, K. J.; Cohen, H. Y.; Lamming, D. W.; Lavu, S.; Wood, J. G.; Zipkin, R. E.; Chung, P.; Kisielewski, A.; Zhang, L. L.; Scherer, B.; Sinclair, D. A. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan Nature 2003, 425, 191-6
19. Lee, C. W.; Yen, F. L.; Huang, H. W.; Wu, T. H.; Ko, H. H.; Tzeng, W. S.; Lin, C. C. Resveratrol nanoparticle system improves dissolution properties and enhances the hepatoprotective effect of resveratrol through antioxidant and anti-inflammatory pathways J. Agric. Food Chem. 2012, 60, 4662-71
20. Lee, Y. J.; Im, J. H.; Won, S. Y.; Kim, Y. B.; Cho, M. K.; Nam, H. S.; Choi, Y. J.; Lee, S. H. Synergistic anti-cancer effects of resveratrol and chemotherapeutic agent clofarabine against human malignant mesothelioma MSTO-211H cells Food Chem. Toxicol. 2013, 52, 61-8
21. Castillo-Pichardo, L.; Dharmawardhane, S. F. Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer Nutr. Cancer 2012, 64, 1058-69
22. Can, G.; Cakir, Z.; Kartal, M.; Gunduz, U.; Baran, Y. Apoptotic effects of resveratrol, a grape polyphenol, on imatinib-sensitive and resistant K562 chronic myeloid leukemia cells Anticancer Res. 2012, 32, 2673-8
23. Iguchi, K.; Toyama, T.; Ito, T.; Shakui, T.; Usui, S.; Oyama, M.; Iinuma, M.; Hirano, K. Antiandrogenic activity of resveratrol analogs in prostate cancer LNCaP cells J. Androl. 2012, 33, 1208-15
24. Juan, M. E.; Alfaras, I.; Planas, J. M. Colorectal cancer chemoprevention by trans-resveratrol Pharmacol. Res. 2012, 65, 584-91
25. Chao, W.; Xuexin, Z.; Jun, S.; Ming, C.; Hua, J.; Li, G.; Tan, C.; Xu, W. Effects of resveratrol on cell growth and prolactin synthesis in GH3 cells Exp. Ther. Med. 2014, 7, 923-928
26. Yang, X.; Li, X.; Ren, J. From French Paradox to cancer treatment: anti-cancer activities and mechanisms of resveratrol Anti-Cancer Agents Med. Chem. 2014, 14, 806-25
27. Park, D. G. Antichemosensitizing effect of resveratrol in cotreatment with oxaliplatin in HCT116 colon cancer cell Ann. Surg. Treat. Res. 2014, 86, 68-75
28. Yan, H. W.; Hu, W. X.; Zhang, J. Y.; Wang, Y.; Xia, K.; Peng, M. Y.; Liu, J. Resveratrol induces human K562 cell apoptosis, erythroid differentiation, and autophagy Tumor Biol. 2014, 35, 5381-8
29. Ge, J.; Liu, Y.; Li, Q.; Guo, X.; Gu, L.; Ma, Z. G.; Zhu, Y. P. Resveratrol induces apoptosis and autophagy in T-cell acute lymphoblastic leukemia cells by inhibiting Akt/mTOR and activating p38-MAPK Biomed. Environ. Sci. 2013, 26, 902-11
30. Zou, T.; Yang, Y.; Xia, F.; Huang, A.; Gao, X.; Fang, D.; Xiong, S.; Zhang, J. Resveratrol inhibits CD4+ T cell activation by enhancing the expression and activity of Sirt1 PloS One 2013, 8, e75139
31. Jazirehi, A. R.; Bonavida, B. Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis Mol. Cancer Ther. 2004, 3, 71-84
32. Surh, Y. J.; Hurh, Y. J.; Kang, J. Y.; Lee, E.; Kong, G.; Lee, S. J. Resveratrol, an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia (HL-60) cells Cancer Lett. 1999, 140, 1-10
33. Gonzalez-Sarrias, A.; Gromek, S.; Niesen, D.; Seeram, N. P.; Henry, G. E. Resveratrol oligomers isolated from Carex species inhibit growth of human colon tumorigenic cells mediated by cell cycle arrest J. Agric. Food Chem. 2011, 59, 8632-8
34. Suzuki, Y.; Ito, S.; Sasaki, R.; Asahi, M.; Ishida, Y. Resveratrol suppresses cell proliferation via inhibition of STAT3 phosphorylation and Mcl-1 and cIAP-2 expression in HTLV-1-infected T cells Leuk. Res. 2013, 37, 1674-9
35. Ahmad, K. A.; Clement, M. V.; Hanif, I. M.; Pervaiz, S. Resveratrol inhibits drug-induced apoptosis in human leukemia cells by creating an intracellular milieu nonpermissive for death execution Cancer Res. 2004, 64, 1452-9
36. Zunino, S. J.; Storms, D. H. Resveratrol alters proliferative responses and apoptosis in human activated B lymphocytes in vitro J. Nutr. 2009, 139, 1603-8
37. Krzewski, K.; Strominger, J. L. The killer's kiss: The many functions of NK cell immunological synapses Curr. Opin. Cell Biol. 2008, 20, 597-605
38. Lu, C. C.; Chen, J. K. Resveratrol enhances perforin expression and NK cell cytotoxicity through NKG2D-dependent pathways J. Cell. Physiol. 2010, 223, 343-51
39. Hu, L.; Cao, D.; Li, Y.; He, Y.; Guo, K. Resveratrol sensitized leukemia stem cell-like KG-1a cells to cytokine-induced killer cells-mediated cytolysis through NKG2D ligands and TRAIL receptors Cancer Biol. Ther. 2012, 13, 516-26
40. Bachleda, P.; Vrzal, R.; Dvorak, Z. Resveratrol enhances NK cell cytotoxicity: Possible role for aryl hydrocarbon receptor J. Cell. Physiol. 2010, 225, 289-90
41. Calabrese, E. J.; Mattson, M. P.; Calabrese, V. Resveratrol commonly displays hormesis: Occurrence and biomedical significance Hum. Exp. Toxicol. 2010, 29, 980-1015
42. Timmers, S.; Auwerx, J.; Schrauwen, P. The journey of resveratrol from yeast to human Aging 2012, 4, 146-58
43. Goldberg, D. M.; Yan, J.; Soleas, G. J. Absorption of three wine-related polyphenols in three different matrices by healthy subjects Clin. Biochem. 2003, 36, 79-87