메뉴 건너뛰기




Volumn 237, Issue 2, 2014, Pages 705-710

ETC-1002: A future option for lipid disorders?

Author keywords

Cardiometabolic risk; ETC 1002; Lipid lowering therapy; Low density lipoprotein cholesterol

Indexed keywords

ADENOSINE TRIPHOSPHATE CITRATE LYASE; ANTILIPEMIC AGENT; APOLIPOPROTEIN B; DICARBOXYLIC ACID DERIVATIVE; ETC 1002; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LONG CHAIN FATTY ACID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; UNCLASSIFIED DRUG;

EID: 84910066978     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2014.10.099     Document Type: Review
Times cited : (43)

References (24)
  • 1
    • 84884366154 scopus 로고    scopus 로고
    • Efficacy and safety of a novel dual modulator of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase in patients with hypercholesterolemia: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial
    • Ballantyne C.M., Davidson M.H., Macdougall D.E., et al. Efficacy and safety of a novel dual modulator of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase in patients with hypercholesterolemia: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial. J.Am. Coll. Cardiol. 2013, 62:1154-1162.
    • (2013) J.Am. Coll. Cardiol. , vol.62 , pp. 1154-1162
    • Ballantyne, C.M.1    Davidson, M.H.2    Macdougall, D.E.3
  • 3
    • 84910057842 scopus 로고    scopus 로고
    • Available from
    • Esperion Therapeutics, Inc., Available from:. http://www.esperion.com/therapies-progress/clinical-studies/.
  • 4
    • 84922593883 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin/kexin 9 inhibitors: an emerging lipid-lowering therapy?
    • Dragan S., Serban M.C., Banach M. Proprotein convertase subtilisin/kexin 9 inhibitors: an emerging lipid-lowering therapy?. J.Cardiovasc. Pharmacol. Ther. 2014, 10.1177/1074248414539562.
    • (2014) J.Cardiovasc. Pharmacol. Ther.
    • Dragan, S.1    Serban, M.C.2    Banach, M.3
  • 5
    • 84903717113 scopus 로고    scopus 로고
    • Lipid, blood pressure and kidney update 2013
    • Banach M., Serban C., Aronow W.S., et al. Lipid, blood pressure and kidney update 2013. Int. Urol. Nephrol. 2014, 46:947-961.
    • (2014) Int. Urol. Nephrol. , vol.46 , pp. 947-961
    • Banach, M.1    Serban, C.2    Aronow, W.S.3
  • 7
    • 84866851179 scopus 로고    scopus 로고
    • Lipid-lowering therapies and achievement of LDL-cholesterol targets
    • Rizzo M., Banach M., Montalto G., Mikhailidis D.P. Lipid-lowering therapies and achievement of LDL-cholesterol targets. Arch. Med. Sci. 2012, 8:598-600.
    • (2012) Arch. Med. Sci. , vol.8 , pp. 598-600
    • Rizzo, M.1    Banach, M.2    Montalto, G.3    Mikhailidis, D.P.4
  • 8
    • 84910057841 scopus 로고    scopus 로고
    • Available from
    • Esperion Therapeutics, Inc. 2014. Available from:. http://files.shareholder.com/downloads/AMDA-1UZG66/0x0x744443/0A0F2E62-8FAD-443C-B531-0F768179B9F7/ESPR_Annual_Report_2014_040214_FINAL__FINAL.PDF.
    • (2014)
  • 9
    • 84910036155 scopus 로고    scopus 로고
    • Understanding Key Pathways. Available from
    • Understanding Key Pathways. Available from:. http://www.esperion.com/our-pathways-approach/understanding-key-pathways/.
  • 10
    • 84871226706 scopus 로고    scopus 로고
    • AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism
    • Pinkosky S.L., Filippov S., Srivastava R.A., et al. AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism. J.Lipid Res. 2013, 54:134-151.
    • (2013) J.Lipid Res. , vol.54 , pp. 134-151
    • Pinkosky, S.L.1    Filippov, S.2    Srivastava, R.A.3
  • 13
    • 84894514648 scopus 로고    scopus 로고
    • Targeting low-density lipoprotein and dysmetabolism in type 2 diabetes mellitus
    • Goldberg R. Targeting low-density lipoprotein and dysmetabolism in type 2 diabetes mellitus. Arterioscler. Thromb. Vasc. Biol. 2014, 34:477-478.
    • (2014) Arterioscler. Thromb. Vasc. Biol. , vol.34 , pp. 477-478
    • Goldberg, R.1
  • 14
    • 84881255684 scopus 로고    scopus 로고
    • ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK
    • Filippov S., Pinkosky S.L., Lister R.J., et al. ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK. J.Lipid Res. 2013, 54:2095-2108.
    • (2013) J.Lipid Res. , vol.54 , pp. 2095-2108
    • Filippov, S.1    Pinkosky, S.L.2    Lister, R.J.3
  • 16
    • 85096202361 scopus 로고    scopus 로고
    • -/- Mouse by a Lipid-dependent and Independent Mechanism
    • C.T. Cramer, R.A. Srivastava, J. Lutostanski, C.L. Bisgaier, R.S. Newton (Eds.)
    • -/- Mouse by a Lipid-dependent and Independent Mechanism. ATVB Scientific Session: 137, Abstract 405 2011, C.T. Cramer, R.A. Srivastava, J. Lutostanski, C.L. Bisgaier, R.S. Newton (Eds.).
    • (2011) ATVB Scientific Session: 137, Abstract 405
  • 17
    • 84910057840 scopus 로고    scopus 로고
    • ANovel Small Molecule, ETC-1002, Lowers Proatherogenic Lipoproteins, Reduces Adiposity, and Improves Hepatic Steatosis in a Hyperlipidemic Hamster Model
    • R.A. Srivastava, T.R. Hurley, A.F. Brant (Eds.)
    • ANovel Small Molecule, ETC-1002, Lowers Proatherogenic Lipoproteins, Reduces Adiposity, and Improves Hepatic Steatosis in a Hyperlipidemic Hamster Model. ATVB Scientific Session: 55, Abstract 97 2011, R.A. Srivastava, T.R. Hurley, A.F. Brant (Eds.).
    • (2011) ATVB Scientific Session: 55, Abstract 97
  • 18
    • 84910077838 scopus 로고    scopus 로고
    • ETC-1002 Reduces Circulating and Hepatic Triglyceride Content and Improves Glycemic Control in KKAy Mice
    • J.C. Hanselman, C.D. Bradshaw, A.F. Brant (Eds.)
    • ETC-1002 Reduces Circulating and Hepatic Triglyceride Content and Improves Glycemic Control in KKAy Mice. ATVB Scientific Session: 177, Abstract 554 2011, J.C. Hanselman, C.D. Bradshaw, A.F. Brant (Eds.).
    • (2011) ATVB Scientific Session: 177, Abstract 554
  • 21
    • 84910036152 scopus 로고    scopus 로고
    • Ezetimibe, and the Combination in Hypercholesterolemic Patients (NCT01941836). Available from
    • Evaluation of ETC-1002, Ezetimibe, and the Combination in Hypercholesterolemic Patients (NCT01941836). Available from:. https://clinicaltrials.gov/ct2/show/NCT01941836?term=%2522ETC-1002%2522&rank=5.
  • 22
    • 84894573802 scopus 로고    scopus 로고
    • Efficacy and safety of ETC-1002, a novel investigational low-density lipoprotein-cholesterol-lowering therapy for the treatment of patients with hypercholesterolemia and type 2 diabetes mellitus
    • Gutierrez M.J., Rosenberg N.L., Macdougall D.E., et al. Efficacy and safety of ETC-1002, a novel investigational low-density lipoprotein-cholesterol-lowering therapy for the treatment of patients with hypercholesterolemia and type 2 diabetes mellitus. Arterioscler. Thromb. Vasc. Biol. 2014, 34:676-683.
    • (2014) Arterioscler. Thromb. Vasc. Biol. , vol.34 , pp. 676-683
    • Gutierrez, M.J.1    Rosenberg, N.L.2    Macdougall, D.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.