Sperm motility inversely correlates with seminal leptin levels in idiopathic asthenozoospermia

International Journal of Clinical and Experimental Medicine

Volumn 7, Issue 10, 2014, Pages 3550-3555

  Guo, Jianhua ^a,b   Zhao, Yang ^a   Huang, Weiying ^c   Hu, Wei ^b   Gu, Jianjun ^b   Chen, Chuhong ^b   Zhou, Juan ^a   Peng, Yubing ^a   Gong, Min ^b   Wang, Zhong ^a  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^b FUDAN UNIVERSITY PUDONG MEDICAL CENTER   (China)

^c Department of General Family Medicine Zhuqiao Community Health Service Centre   (China)

Author keywords

Idiopathic asthenozoospermia; Seminal leptin; Serum leptin; Sperm motility

Indexed keywords

ESTRADIOL; FOLLITROPIN; GONADOTROPIN; LEPTIN; LUTEINIZING HORMONE; PROLACTIN; SEX HORMONE; TESTOSTERONE;

ADULT; ARTICLE; ASTHENOSPERMIA; BODY MASS; CHEMILUMINESCENCE IMMUNOASSAY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; MAJOR CLINICAL STUDY; MALE; MALE GENITAL TRACT PARAMETERS; SEMEN ANALYSIS; SEMEN VOLUME; SEMINAL PLASMA; SERUM; SPERM MORPHOLOGY; SPERM QUALITY; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY;

EID: 84910026673     PISSN: None     EISSN: 19405901     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Fisher JR and Hammarberg K. Psychological and social aspects of infertility in men: an overview of the evidence and implications for psychologically informed clinical care and future research. Asian J Androl 2012; 14: 121-129.
2. Alam N. Male factor infertility--basics revisited. J Coll Physicians Surg Pak 2009; 19: 205-206.
3. Curi SM, Ariagno JI, Chenlo PH, Mendeluk GR, Pugliese MN, Sardi Segovia LM, Repetto HE and Blanco AM. Asthenozoospermia: analysis of a large population. Arch Androl 2003; 49: 343-349.
4. Luconi M, Forti G and Baldi E. Pathophysiology of sperm motility. Front Biosci 2006; 11: 1433-1447.
5. Martini AC, Tissera A, Estofán D, Molina RI, Mangeaud A, de Cuneo MF and Ruiz RD. Overweight and seminal quality: a study of 794 patients. Fertil Steril 2010; 94: 1739-1743.
6. Jaiswal D, Sah R, Agrawal NK, Dwivedi US, Trivedi S and Singh K. Combined effect of GSTT1 and GSTM1 polymorphisms on human male infertility in north Indian population. Reprod Sci 2012; 19: 312-316.
7. Ortega C, Verheyen G, Raick D, Camus M, Devroey P and Tournaye H. Absolute asthenozoospermia and ICSI: what are the options? Hum Reprod Update 2011; 17: 684-692.
8. Homan GF, Davies M and Norman R. The impact of lifestyle factors on reproductive performance in the general population and those undergoing infertility treatment: a review. Hum Reprod Update 2007; 13: 209-223.
9. Fernandez CD, Bellentani FF, Fernandes GS, Perobelli JE, Favareto AP, Nascimento AF, Cicogna AC and Kempinas WD. Diet-induced obesity in rats leads to a decrease in sperm motility. Reprod Biol Endocrinol 2011; 9: 32.
10. Andò S and Aquila S. Arguments raised by the recent discovery that insulin and leptin are expressed in and secreted by human ejaculated spermatozoa. Mol Cell Endocrinol 2005; 245: 1-6.
11. WHO. WHO Laboratory Manual for the Exa-mination of Human Semen and Sperm-cervical Mucus Interaction, 5th edn. Cambridge: Cambridge University Press 2010.
12. Hofny ER, Ali ME, Abdel-Hafez HZ, Kamal Eel D, Mohamed EE, Abd El-Azeem HG and Mostafa T. Semen parameters and hormonal profile in obese fertile and infertile males. Fertil Steril 2010; 94: 581-584.
13. Hammoud AO, Carrell DT, Gibson M, Peterson CM and Meikle AW. Updates on the relation of weight excess and reproductive function in men: sleep apnea as a new area of interest. Asian J Androl 2012; 14: 77-81.
14. Fejes I, Koloszár S, Závaczki Z, Daru J, Szöllösi J, Pál A. Effect of body weight on testosterone/estradiol ratio in oligozoospermic patients. Arch Androl 2006; 52: 97-102.
15. Jensen TK, Andersson AM, Jorgensen N, Andersen AG, Carlsen E, Petersen JH and Skakkebaek NE. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril 2004; 82: 863-870.
16. Shultz TD and Howie BJ. In vitro binding of steroid hormones by natural and purified fibers. Nutr Cancer 1986; 8: 141-147.
17. Caprio M, Isidori AM, Carta AR, Moretti C, Dufau ML and Fabbri A. Expression of functional leptin receptors in rodent Leydig cells. Endocrinology 1999; 140: 4939-4947.
18. El-Hefnawy T, Ioffe S and Dym M. Expression of the leptin receptor during germ cell development in the mouse testis. Endocrinology 2000; 141: 2624-2630.
19. Chen B, Guo JH, Lu YN, Ying XL, Hu K, Xiang ZQ, Wang YX, Chen P and Huang YR. Leptin and varicocele-related spermatogenesis dysfunction: animal experiment and clinical study. Int J Androl 2009; 32: 532-541.
20. Ishikawa T, Fujioka H, Ishimura T, Takenaka A and Fujisawa M. Expression of leptin and leptin receptor in the testis of fertile and infertile patients. Andrologia 2007; 39: 22-27.
21. Tena-Sempere M, Pinilla L, González LC, Diéguez C, Casanueva FF and Aguilar E. Leptin in hibits testosterone secretion from adult rat testis in vitro. J Endocrinol 1999; 161: 211-218.
22. Tena-Sempere M, Manna PR, Zhang FP, Pinilla L, González LC, Diéguez C, Huhtaniemi I and Aguilar E. Molecular mechanisms of leptin action in adult rat testis: potential targets for leptin-induced inhibition of steroidogenesis and pattern of leptin receptor messenger ribonucleic acid expression. J Endocrinol 2001; 170: 413-423.
23. Fombonne J, Charrier C, Goddard I, Moyse E and Krantic S. Leptin-mediated decrease of cyclin A2 and increase of cyclin D1 expression: relevance for the control of prepubertal rat Leydig cell division and differentiation. Endocrinology 2007; 148: 2126-2137.
24. Banks WA, McLay RN, Kastin AJ, Sarmiento U and Scully S. Passage of leptin across the blood-testis barrier. Am J Physiol 1999; 276: E1099-1104.
25. Zorn B, Osredkar J, Meden-Vrtovec H and Majdic G. Leptin levels in infertile male patients are correlated with inhibin B, testosterone and SHBG but not with sperm characteristics. Int J Androl 2007; 30: 439-444.
26. Glander HJ, Lammert A, Paasch U, Glasow A and Kratzsch J. Leptin exists in tubuli seminiferi and in seminal plasma. Andrologia 2002; 34: 227-233.
27. Jope T, Lammert A, Kratzsch J, Paasch U and Glander HJ. Leptin and leptin receptor in human seminal plasma and in human spermatozoa. Int J Androl 2003; 26: 335-341.
28. Aquila S, Gentile M, Middea E, Catalano S, Morelli C, Pezzi V and Andò S. Leptin secretion by human ejaculated spermatozoa. J Clin Endocrinol Metab 2005; 90: 4753-4761.