Targeting miR-21 sensitizes Ph+ ALL Sup-b15 cells to imatinib-induced apoptosis through upregulation of PTEN

Biochemical and Biophysical Research Communications

Volumn 454, Issue 3, 2014, Pages 423-428

  Wang, Wei Zhang ^a   Lin, Xiang Hua ^b   Pu, Qiao Hong ^a   Liu, Man Yu ^a   Li, Li ^c   Wu, Li Rong ^a   Wu, Qing Qing ^a   Mao, Jian Wen ^a   Zhu, Jia Yong ^a   Jin, Xiao Bao ^a  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

Author keywords

Apoptosis; Imatinib; MiR 21; PTEN; Sup b15 cells

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; IMATINIB; MICRORNA 21; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; WORTMANNIN; ANTAGOMIR-122; ANTINEOPLASTIC AGENT; MICRORNA; MIRN21 MICRORNA, HUMAN; OLIGONUCLEOTIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR; PTEN PROTEIN, HUMAN; SMALL INTERFERING RNA;

ACUTE LYMPHOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PHILADELPHIA CHROMOSOME POSITIVE CELL; PROTEIN DEPHOSPHORYLATION; UPREGULATION; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; DRUG RESISTANCE; GENE EXPRESSION REGULATION; GENETICS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RNA INTERFERENCE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMATINIB MESYLATE; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MICRORNAS; OLIGONUCLEOTIDES; PHOSPHATIDYLINOSITOL 3-KINASES; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN KINASE INHIBITORS; PTEN PHOSPHOHYDROLASE; RNA INTERFERENCE; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 84910022242     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.10.107     Document Type: Article

References (30)

1. H. Inaba, M. Greaves, and C.G. Mullighan Acute lymphoblastic leukaemia Lancet 381 2013 1943 1955
2. H.J. Lee, J.E. Thompson, E.S. Wang, and M. Wetzler Philadelphia chromosome-positive acute lymphoblastic leukemia: current treatment and future perspectives Cancer 117 2011 1583 1594
3. M.W. Deininger, J.M. Goldman, and J.V. Melo The molecular biology of chronic myeloid leukemia Blood 96 2000 3343 3356
4. B.J. Druker Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia N. Engl. J. Med. 355 2006 2408 2417
5. D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2004 281 297
6. T. Dalmay, and D.R. Edwards MicroRNAs and the hallmarks of cancer Oncogene 25 2006 6170 6175
7. J.B. Weidhaas, I. Babar, S.M. Nallur, P. Trang, S. Roush, M. Boehm, E. Gillespie, and F.J. Slack MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy Cancer Res. 67 2007 11111 11116
8. G. Chen, W. Zhu, D. Shi, L. Lv, C. Zhang, P. Liu, and W. Hu MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2 Oncol. Rep. 23 2010 997 1003
9. H.S. Gwak Silencing of microRNA-21 confers radio-sensitivity through inhibition of the PI3K/AKT pathway and enhancing autophagy in malignant glioma cell lines PLoS One 7 2012 e47449
10. S. Volinia Reprogramming of miRNA networks in cancer and leukemia Genome Res. 20 2010 589 599
11. X. Pan, Z.X. Wang, and R. Wang MicroRNA-21: a novel therapeutic target in human cancer Cancer Biol. Ther. 10 2010 1224 1232
12. H. Quentmeier, S. Eberth, J. Romani, M. Zaborski, and H.G. Drexler BCR-ABL1-independent PI3Kinase activation causing imatinib-resistance J. Hematol. Oncol. 4 2011 6
13. W.Z. Wang, J. Cheng, J. Luo, and S.M. Zhuang Abrogation of G2/M arrest sensitizes curcumin-resistant hepatoma cells to apoptosis FEBS Lett. 582 2008 2689 2695
14. J.K. Chan, K. Blansit, T. Kiet, A. Sherman, G. Wong, C. Earle, and L.Y. Bourguignon The inhibition of miR-21 promotes apoptosis and chemosensitivity in ovarian cancer Gynecol. Oncol. 132 2014 739 744
15. L.F. Xu, Z.P. Wu, Y. Chen, Q.S. Zhu, S. Hamidi, and R. Navab MicroRNA-21 (miR-21) regulates cellular proliferation, invasion, migration, and apoptosis by targeting PTEN, RECK and Bcl-2 in lung squamous carcinoma, Gejiu City, China PLoS One 9 2014 e103698
16. M.E. Gorre, M. Mohammed, K. Ellwood, N. Hsu, R. Paquette, P.N. Rao, and C.L. Sawyers Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification Science 293 2001 876 880
17. J. Thomas, L. Wang, R.E. Clark, and M. Pirmohamed Active transport of imatinib into and out of cells: implications for drug resistance Blood 104 2004 3739 3745
18. Y. Hu Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia Nat. Genet. 36 2004 453 461
19. J. Ding, J. Romani, M. Zaborski, R.A. MacLeod, S. Nagel, H.G. Drexler, and H. Quentmeier Inhibition of PI3K/mTOR overcomes nilotinib resistance in BCR-ABL1 positive leukemia cells through translational down-regulation of MDM2 PLoS One 8 2013 e83510
20. C.H. Yang, J. Yue, M. Fan, and L.M. Pfeffer IFN induces miR-21 through a signal transducer and activator of transcription 3-dependent pathway as a suppressive negative feedback on IFN-induced apoptosis Cancer Res. 70 2010 8108 8116
21. D. Loffler Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer Blood 110 2007 1330 1333
22. F. Meng, R. Henson, H. Wehbe-Janek, K. Ghoshal, S.T. Jacob, and T. Patel MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer Gastroenterology 133 2007 647 658
23. P. Wang MicroRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells Cancer Res. 69 2009 8157 8165
24. L.Y. Bourguignon, C.C. Spevak, G. Wong, W. Xia, and E. Gilad Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells J. Biol. Chem. 284 2009 26533 26546
25. E.C. Connolly, K. Van Doorslaer, L.E. Rogler, and C.E. Rogler Overexpression of miR-21 promotes an in vitro metastatic phenotype by targeting the tumor suppressor RHOB Mol. Cancer Res. 8 2010 691 700
26. X. Ma, M. Kumar, S.N. Choudhury, L.E. Becker Buscaglia, J.R. Barker, K. Kanakamedala, M.F. Liu, and Y. Li Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis Proc. Natl. Acad. Sci. U.S.A. 108 2011 10144 10149
27. M. Liu, H. Wu, T. Liu, Y. Li, F. Wang, H. Wan, X. Li, and H. Tang Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma Cell Res. 19 2009 828 837
28. F.M. Selaru MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3 Hepatology 49 2009 1595 1601
29. L.B. Frankel, N.R. Christoffersen, A. Jacobsen, M. Lindow, A. Krogh, and A.H. Lund Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells J. Biol. Chem. 283 2008 1026 1033
30. R. Polak, and M. Buitenhuis The PI3K/PKB signaling module as key regulator of hematopoiesis: implications for therapeutic strategies in leukemia Blood 119 2012 911 923